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NCT05663866 · ClinicalTrials.gov registry record · Phase 2
Premedication to Reduce Amivantamab Associated Infusion Related Reactions
A Phase 2 study of Carcinoma, Non-Small Cell Lung, sponsored by Janssen Research & Development.
- Active
- Registry status
- Phase 2
- Development phase
- 68
- Enrollment target
- 20
- Study locations
NCT05663866 is a Phase 2 study of Carcinoma, Non-Small Cell Lung that is active but no longer recruiting, run by Janssen Research & Development. The registered enrollment target is 68 participants, below the 323-participant average among 130 other Carcinoma, Non-Small Cell Lung trials with a reported enrollment target (79% lower). The trial reports 20 study locations across 4 states.
The verdict
NCT05663866, a Phase 2 study of Carcinoma, Non-Small Cell Lung, is active but no longer recruiting, sponsored by Janssen Research & Development.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 2
- Development phase
- 68 participants
- Enrollment target
- 20
- Study locations
Study Summary
The purpose of the study is to separately assess the potential of dexamethasone, montelukast and methotrexate administration, prior to amivantamab infusion given through a needle in the vein, to decrease the incidence and/or severity of first-dose infusion related reactions.
Conditions Studied
Interventions
- DRUG Dexamethasone
- DRUG Montelukast
- DRUG Methotrexate
- DRUG Amivantamab
- DRUG Lazertinib
Study Locations (20)
Other
- CHU de Brest - Hopital de la Cavale Blanche - Brest
- Centre Leon Berard - Lyon
- Hopital Cochin - Paris
- Hopital Europeen Georges-Pompidou - Paris
- CHU Rouen Hopital Charles Nicolle - Rouen
- Nouvel Hopital Civil - CHU Strasbourg - Strasbourg
- Chungbuk National University Hospital - Cheongju-si
- National Cancer Center - Gyeonggi-do
- Gachon University Gil Medical Center - Incheon
- Chonnam National University Hwasun Hospital - Jeollanam-do
- Seoul National University Bundang Hospital - Seongnam-si
- Asan Medical Center - Seoul
- Hosp. de La Santa Creu I Sant Pau - Barcelona
- Hosp Univ Vall D Hebron - Barcelona
- Hosp. Univ. Quiron Dexeus - Barcelona
- Hosp. San Pedro de Alcantara - Cáceres
- Hosp. de Jerez de La Frontera - Jerez de la Frontera
California
- Compassionate Cancer Care - Fountain Valley
Virginia
- Virginia Cancer Specialists - Fairfax
Washington
- UW Medicine Valley Medical Center - Renton
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 68 participants |
| Start Date | 2023-05-18 |
| Est. Completion | 2026-07-30 |
| Phase | Phase 2 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT05663866
The ClinicalTrials.gov registry entry for NCT05663866 describes a study currently listed as active not recruiting, categorized as Phase 2. The registered enrollment target is 68 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 323-participant average among 130 other Carcinoma, Non-Small Cell Lung trials with a reported enrollment target (79% lower). The listed sponsor is Janssen Research & Development, which has 593 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Carcinoma, Non-Small Cell Lung appearing as the primary indexed condition, and to 5 interventions - of which Dexamethasone is the first listed.
NCT05663866 reports 20 study locations spanning 4 distinct geographic areas - top geographies include Other, California, Virginia.
Frequently Asked Questions
What is clinical trial NCT05663866 about?
NCT05663866 is a clinical study titled "Premedication to Reduce Amivantamab Associated Infusion Related Reactions". The purpose of the study is to separately assess the potential of dexamethasone, montelukast and methotrexate administration, prior to amivantamab infusion given through a needle in the vein, to decrease the incidence and/or severity of first-dose infusion related reactions.
What is the current status of trial NCT05663866?
This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 68 participants. The study started on 2023-05-18. Estimated completion is 2026-07-30.
What conditions does trial NCT05663866 study?
This clinical trial studies the following conditions: Carcinoma, Non-Small Cell Lung.
What interventions are being tested in trial NCT05663866?
The interventions under investigation include: Dexamethasone (DRUG), Montelukast (DRUG), Methotrexate (DRUG), Amivantamab (DRUG), Lazertinib (DRUG).
Who is sponsoring clinical trial NCT05663866?
This trial is sponsored by Janssen Research & Development, which has 593 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05663866 being conducted?
This trial has 20 study locations across California, Virginia, Washington. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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