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ACTIVE NOT RECRUITING Phase 1

A Clinical Trial of PF-08046037 Alone or With Sasanlimab in Patients With Advanced or Metastatic Malignancies

NCT06974734 · View on ClinicalTrials.gov ↗

Study Summary

The purpose of this study is to learn about the safety and the effects of PF-08046037 alone or with sasanlimab for the treatment of certain advanced or metastatic malignancies. This study is seeking participants who: * have advanced or metastatic non-small cell lung cancer (NSCLC), head and neck squamous cell carcinoma (HNSCC), melanoma, or pancreatic ductal adenocarcinoma (PDAC); * are able to provide tumor tissue samples; * have measurable disease. All participants will receive while at the clinic PF-08046037 alone as an intravenous (IV) infusion (given directly into a vein) or with sasanlimab as a subcutaneous (SQ) injection (given under the skin) once every 3 weeks. Participants will continue to take the study drug(s) until their cancer is no longer responding or if the patient cannot safely take them. The study team will monitor how each participant is doing with the study treatment during regular visits at the study clinic.

Interventions

  • DRUG PF-08046037
  • DRUG sasanlimab

Study Locations (15)

Connecticut

  • Smilow Cancer Hospital - Yale New Haven Health — New Haven
  • Yale - New Haven Hospital - Yale Cancer Center — New Haven
  • Smilow Cancer Hospital Phase 1 Unit — New Haven
  • Smilow Cancer Hospital - Trumbull — Trumbull

Indiana

  • Community Health Network, Inc — Indianapolis
  • Community Health Network, Inc. — Indianapolis
  • Community Health Network, Inc. — Indianapolis
  • Community Health Network, Inc. — Indianapolis

Tennessee

  • Sarah Cannon Research Institute - Pharmacy — Nashville
  • SCRI Oncology Partners — Nashville
  • Tristar Centennial Medical Center — Nashville

Colorado

  • Presbyterian/ St. Lukes Medical Center — Denver
  • Sarah Cannon Research Institute at HealthONE — Denver

Michigan

  • START Midwest — Grand Rapids

Other

  • Pan American Center for Oncology Trials, LLC — Rio Piedras

Trial Details

FieldValue
Enrollment Target 9 participants
Start Date 2025-05-06
Est. Completion 2026-04-30
Phase Phase 1

Sponsor

Pfizer

769 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT06974734

The ClinicalTrials.gov registry entry for NCT06974734 describes a study currently listed as active not recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 9 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Pfizer, which has 769 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 4 conditions, with Malignant Melanoma appearing as the primary indexed condition, and to 2 interventions — of which PF-08046037 is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT06974734 reports 15 study locations spanning 6 distinct geographic areas — top geographies include Connecticut, Indiana, Tennessee. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT06974734 about?

NCT06974734 is a clinical study titled "A Clinical Trial of PF-08046037 Alone or With Sasanlimab in Patients With Advanced or Metastatic Malignancies". The purpose of this study is to learn about the safety and the effects of PF-08046037 alone or with sasanlimab for the treatment of certain advanced or metastatic malignancies. This study is seeking participants who: * have advanced or metastatic non-small cell lung cancer (NSCLC), head and neck s...

What is the current status of trial NCT06974734?

This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 9 participants. The study started on 2025-05-06. Estimated completion is 2026-04-30.

What conditions does trial NCT06974734 study?

This clinical trial studies the following conditions: Malignant Melanoma, Carcinoma, Pancreatic Ductal, Carcinoma, Non Small Cell Lung, Squamous Cell Carcinoma of the Head and Neck (SCCHN). These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT06974734?

The interventions under investigation include: PF-08046037 (DRUG), sasanlimab (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT06974734?

This trial is sponsored by Pfizer, which has 769 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT06974734 being conducted?

This trial has 15 study locations across Colorado, Connecticut, Indiana, Michigan, Tennessee. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial