Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NT-I7 in Combination With Atezolizumab in Previously Untreated, PD-L1-expressing, Locally Advanced or Metastatic NSCLC
NCT04984811 · View on ClinicalTrials.gov ↗
Study Summary
This is a multicenter, open-label, single-arm Phase II study to evaluate anti-tumor efficacy and safety of NT-I7 in combination with atezolizumab in subjects with PD-L1-expressing (TPS ≥ 1%), metastatic (Stage IV) or locally advanced squamous or non-squamous NSCLC who have not received prior systemic therapy in the metastatic or locally advanced setting. Eligible subjects must have measurable disease according to RECIST 1.1. This Phase II study will enroll up to 83 subjects.
Conditions Studied
Interventions
- DRUG Atezolizumab
- DRUG efineptakin alfa
Study Locations (20)
Florida
- Florida Cancer Specialists - South Research Office — Fort Myers
- BRCR Medical Center — Plantation
- Florida Cancer Specialists - North Research Office — St. Petersburg
- Florida Cancer Specialists - East Research Office — West Palm Beach
Tennessee
- Tennessee Oncology - Chattanooga — Chattanooga
- Thompson Cancer Survival Center — Knoxville
- Tennessee Oncology - Nashville — Nashville
Kentucky
- Norton Cancer Institute — Louisville
- Pikeville Medical Center, Inc. — Pikeville
Alabama
- University of South Alabama — Mobile
California
- TOI Clinical Research — Cerritos
Connecticut
- Eastern CT Hematology & Oncology Associates — Norwich
Georgia
- University Cancer and Blood Center — Athens
Indiana
- Goshen Center for Cancer Care — Goshen
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 83 participants |
| Start Date | 2021-11-03 |
| Est. Completion | 2025-03 |
| Phase | Phase 2 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT04984811
The ClinicalTrials.gov registry entry for NCT04984811 describes a study currently listed as active not recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 83 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is NeoImmuneTech, which has 2 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 5 conditions, with Non Small Cell Lung Cancer appearing as the primary indexed condition, and to 2 interventions — of which Atezolizumab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT04984811 reports 20 study locations spanning 14 distinct geographic areas — top geographies include Florida, Tennessee, Kentucky. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT04984811 about?
NCT04984811 is a clinical study titled "NT-I7 in Combination With Atezolizumab in Previously Untreated, PD-L1-expressing, Locally Advanced or Metastatic NSCLC". This is a multicenter, open-label, single-arm Phase II study to evaluate anti-tumor efficacy and safety of NT-I7 in combination with atezolizumab in subjects with PD-L1-expressing (TPS ≥ 1%), metastatic (Stage IV) or locally advanced squamous or non-squamous NSCLC who have not received prior systemi...
What is the current status of trial NCT04984811?
This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 83 participants. The study started on 2021-11-03. Estimated completion is 2025-03.
What conditions does trial NCT04984811 study?
This clinical trial studies the following conditions: Non Small Cell Lung Cancer, Non-Small Cell Lung Cancer, Carcinoma, Non-Small-Cell Lung, Non-Small Cell Lung Carcinoma, Nonsmall Cell Lung Cancer. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT04984811?
The interventions under investigation include: Atezolizumab (DRUG), efineptakin alfa (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT04984811?
This trial is sponsored by NeoImmuneTech, which has 2 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT04984811 being conducted?
This trial has 20 study locations across Alabama, California, Connecticut, Florida, Georgia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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