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ACTIVE NOT RECRUITING Phase 1

A Study of Combination Therapy With Amivantamab and Cetrelimab in Participants With Metastatic Non-small Cell Lung Cancer

NCT05908734 · View on ClinicalTrials.gov ↗

Study Summary

The purpose of this study is to identify the recommended Phase 2 (combination) dose (RP2CD) of the amivantamab and cetrelimab combination therapy in participants with non-small cell lung cancer (NSCLC) in Phase 1 (combination dose selection); and to evaluate the antitumor effect of the combination at the selected RP2CD in participants with NSCLC characterized on the basis of epidermal growth factor receptor (EGFR) and Programmed-cell death Ligand (PD-L)1 status, in the Phase 2 (expansion).

Interventions

  • DRUG Amivantamab
  • DRUG Cetrelimab

Study Locations (20)

Other

  • Fundacao Pio XII — Barretos
  • Cetus Oncologia — Belo Horizonte
  • PERSONAL Oncologia de Precisao e Personalizada — Belo Horizonte
  • CIONC Centro Integrado de Oncologia de Curitiba — Curitiba
  • Hospital do Cancer de Londrina — Londrina
  • Hospital Nossa Senhora da Conceicao S A — Porto Alegre
  • Hospital Santa Izabel Santa Casa de Misericordia da Bahia — Salvador
  • Fundacao Antonio Prudente A C Camargo Cancer Center — São Paulo
  • European Institute of Oncology — Milan
  • ASST Grande Ospedale Metropolitano Niguarda — Milan
  • Aou San Luigi Gonzaga — Orbassano
  • Centro Ricerche Cliniche di Verona S r l — Verona
  • University Malaya Medical Centre — Kuala Lumpur

California

  • City of Hope — Duarte
  • City of Hope Orange County Lennar Foundation Cancer Center — Irvine
  • Cancer and Blood Specialty Clinic — Los Alamitos

Oregon

  • Providence Portland Medical Center — Portland
  • Providence Oncology and Hematology Care Clinic Westside — Portland

Texas

  • MD Anderson Cancer Center — Houston

Virginia

  • Virginia Cancer Specialists — Fairfax

Trial Details

FieldValue
Enrollment Target 71 participants
Start Date 2023-05-18
Est. Completion 2027-03-31
Phase Phase 1

Sponsor

Janssen Research & Development

442 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT05908734

The ClinicalTrials.gov registry entry for NCT05908734 describes a study currently listed as active not recruiting. It is categorized as Phase 1, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 71 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Janssen Research & Development, which has 442 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Carcinoma, Non-Small-Cell Lung appearing as the primary indexed condition, and to 2 interventions — of which Amivantamab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT05908734 reports 20 study locations spanning 5 distinct geographic areas — top geographies include Other, California, Oregon. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT05908734 about?

NCT05908734 is a clinical study titled "A Study of Combination Therapy With Amivantamab and Cetrelimab in Participants With Metastatic Non-small Cell Lung Cancer". The purpose of this study is to identify the recommended Phase 2 (combination) dose (RP2CD) of the amivantamab and cetrelimab combination therapy in participants with non-small cell lung cancer (NSCLC) in Phase 1 (combination dose selection); and to evaluate the antitumor effect of the combination a...

What is the current status of trial NCT05908734?

This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 71 participants. The study started on 2023-05-18. Estimated completion is 2027-03-31.

What conditions does trial NCT05908734 study?

This clinical trial studies the following conditions: Carcinoma, Non-Small-Cell Lung. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT05908734?

The interventions under investigation include: Amivantamab (DRUG), Cetrelimab (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT05908734?

This trial is sponsored by Janssen Research & Development, which has 442 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT05908734 being conducted?

This trial has 20 study locations across California, Oregon, Texas, Virginia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial