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ClinicalTrials.gov 9 recruiting now official registry

Cannabis clinical trials

Every US clinical trial registered for Cannabis — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.

25 US clinical trials · 9 currently recruiting

The research picture

Cannabis has 25 registered US clinical trials, 9 of them open to new participants right now — about 36% of the total.

9
recruiting participants now
36%
of trials open to enrollment
0
in Phase 3–4 (later-stage)
8
top sponsor: Yale University

Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.

Active & Recent Trials

RECRUITING Phase 2 350 participants

Cannabis' Impact on Alcohol Consumption

Brown University

NCT05389930

RECRUITING 320 participants

Cannabis, HIV and Mental Processing Systems

Washington University School of Medicine

NCT05430490

RECRUITING NA 220 participants

Modeling the Effects of Chronic Marijuana Use on Neuroinflammation and HIV-related Neuronal Injury

Wake Forest University Health Sciences

NCT04810858

RECRUITING Phase 1 100 participants

Gender Related Differences in the Acute Effects of Delta-9-Tetrahydrocannabinol in Healthy Humans

Yale University

NCT02781519

RECRUITING Phase 1 100 participants

Gender Related Differences in the Acute Effects of Delta-9-Tetrahydrocannabinol in Healthy Humans: Sub-Study II

Yale University

NCT04704271

RECRUITING Phase 2 90 participants

Effects of Cannabidiol and Tetrahydrocannabinol on Microbiome and Neuroinflammation in HIV

University of California, San Diego

NCT05514899

RECRUITING 64 participants

Cannabis Observations on Brain Waves, Retrieval, and Attention: Experiment 3

L. Cinnamon Bidwell

NCT06669585

RECRUITING Phase 2 48 participants

Understanding the Clinical Pharmacology of Marijuana-Tobacco Co-administration

University of California, San Francis

NCT05999383

RECRUITING Phase 1 40 participants

Gender Related Differences in the Acute Effects of Delta-9-Tetrahydrocannabinol in Healthy Humans: Sub-Study I

Yale University

NCT02811510

ACTIVE NOT RECRUITING Phase 1 80 participants

Cannabinoids, Learning, and Memory

Yale University

NCT02407808

ACTIVE NOT RECRUITING Phase 1 40 participants

Ethanol and Cannabinoid Effects on Simulated Driving and Related Cognition: Sub-Study II

Yale University

NCT02710097

ACTIVE NOT RECRUITING Phase 1 40 participants

Ethanol and Cannabinoid Effects on Simulated Driving and Related Cognition

Yale University

NCT02404688

ACTIVE NOT RECRUITING Phase 1 40 participants

Ethanol and Cannabinoid Effects on Simulated Driving and Related Cognition: Substudy III

Yale University

NCT02710331

ACTIVE NOT RECRUITING Phase 1 40 participants

Ethanol and Cannabinoid Effects on Simulated Driving and Related Cognition: Sub-Study I

Yale University

NCT02709954

ACTIVE NOT RECRUITING Phase 1 20 participants

THC Memory & Reward Learning Pilot

Hartford Hospital

NCT05116527

COMPLETED NA 448 participants

Intervening to Prevent Youth Access to Marijuana Phase II

Klein Buendel

NCT03073291

COMPLETED NA 361 participants

Web-based vs In-person Personalized Feedback Intervention for Comorbid Substance Use and Disordered Gambling

University of Washington

NCT01529047

COMPLETED Phase 2 92 participants

Efficacy of Inhaled Cannabis for Acute Migraine Treatment

University of California, San Diego

NCT04360044

COMPLETED NA 60 participants

Impact of Reduced Cannabis Use on Functional Outcomes (R33 Phase)

Duke University

NCT04567238

COMPLETED NA 35 participants

Pain Inflammation and Cannabis in HIV

Montefiore Medical Center

NCT05554146

COMPLETED NA 29 participants

Families With Substance Use and Psychosis: A Pilot Study

Mclean Hospital

NCT04284813

COMPLETED NA 25 participants

Impact of Reduced Cannabis Use on Functional Outcomes

Duke University

NCT03681353

COMPLETED Phase 1 8 participants

Laboratory Smoking of Marijuana "Blunts"

Battelle Memorial Institute

NCT03546790

COMPLETED Phase 2 5 participants

Effect of Cannabis and Endocannabinoids on HIV Neuropathic Pain

University of California, San Diego

NCT03099005

COMPLETED NA 3 participants

Feasibility Trial of rTMS for Cannabis Use Disorder

Medical University of South Carolina

NCT03538288

Phase Distribution

PhaseTrial count
Phase 1 10
Phase 2 5

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Cannabis Trial Landscape

ClinicalTrials.gov lists 25 US studies indexed under Cannabis, and 9 of those are currently open to recruitment — roughly 36% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Cannabis shows 0 late-stage studies (Phase 3 and Phase 4 combined) alongside 15 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Cannabis is led by Yale University with 8 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 25 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Cannabis?

PlainTrial tracks 25 US clinical trials for Cannabis, of which 9 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Cannabis?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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