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NCT05430490 · ClinicalTrials.gov registry record
Cannabis, HIV and Mental Processing Systems
A clinical trial of HIV Infections and Cannabis, sponsored by Washington University School of Medicine.
- Recruiting
- Registry status
- 320
- Enrollment target
- 2
- Study locations
NCT05430490: Recruiting study of HIV Infections and Cannabis, sponsored by Washington University School of Medicine.
NCT05430490 is a study of HIV Infections and Cannabis that is actively recruiting participants, run by Washington University School of Medicine. The registered enrollment target is 320 participants, below the 445-participant average among 542 other HIV Infections trials with a reported enrollment target (28% lower). The trial reports 2 study locations across 2 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05430490, a study of HIV Infections and Cannabis, is actively recruiting participants, sponsored by Washington University School of Medicine.
- RECRUITING
- Registry status
- 320 participants
- Enrollment target
- 2
- Study locations
Study Summary
This study employs novel methods to identify key determinants and consequences of concurrent HIV infection and regular cannabis use. This study will acquire extensive phenotype data from peripheral and brain markers of immune activation, brain structure, and neuropsychological performance (NP) in persons living with HIV (PLWH) receiving combination anti-retroviral therapy (cART) (80 regular cannabis users and 80 non-users) and HIV uninfected (HIV-) controls (80 regular cannabis users and 80 non-users). This study will provide key insights into the effects of regular cannabis and HIV on peripheral and brain markers of immune function and NP in PLWH and HIV- controls. These insights are critical for cure strategies and ongoing HIV treatment initiatives.
Primary Outcome
Validated plasma and cerebrospinal fluid (CSF) markers of immune health and inflammation (e.g., CD14, CD16, Neopterin, etc.), as well as novel neuroimaging methods of neuro-inflammation (e.g., DTI \& DBSI, 3T MRI) will be used to evaluate brain inflammation.
Conditions Studied
Interventions
- PROCEDURE Lumbar Puncture
- OTHER Questionnaires
- PROCEDURE Blood Draw
- PROCEDURE MRI
- OTHER NeuroPsychological Testing
Study Locations (2)
Missouri
- Washington University School of Medicine - St Louis
New Jersey
- Rutgers University - Newark
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 320 participants |
| Start Date | 2022-03-23 |
| Est. Completion | 2026-06-30 |
What NCT05430490 shows while recruiting
NCT05430490 is an observational study that tracks outcomes without assigning an intervention. The registered 320 participants enrollment target is mid-sized for trials with a published cap, below the 445-participant average among 542 other HIV Infections trials with a reported enrollment target (28% lower).
The record links to 2 conditions, with HIV Infections appearing as the primary indexed condition, and to 5 interventions - of which Lumbar Puncture is the first listed.
NCT05430490 reports a single indexed study location in Missouri, New Jersey.
Frequently Asked Questions
What is clinical trial NCT05430490 about?
NCT05430490 is a clinical study titled "Cannabis, HIV and Mental Processing Systems". This study employs novel methods to identify key determinants and consequences of concurrent HIV infection and regular cannabis use. This study will acquire extensive phenotype data from peripheral and brain markers of immune activation, brain structure, and neuropsychological performance (NP) in pe...
What is the current status of trial NCT05430490?
This trial is currently recruiting. The enrollment target is 320 participants. The study started on 2022-03-23. Estimated completion is 2026-06-30.
What conditions does trial NCT05430490 study?
This clinical trial studies the following conditions: HIV Infections, Cannabis.
What interventions are being tested in trial NCT05430490?
The interventions under investigation include: Lumbar Puncture (PROCEDURE), Questionnaires (OTHER), Blood Draw (PROCEDURE), MRI (PROCEDURE), NeuroPsychological Testing (OTHER).
Who is sponsoring clinical trial NCT05430490?
This trial is sponsored by Washington University School of Medicine, which has 1,502 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05430490 being conducted?
This trial has 2 study locations across Missouri, New Jersey. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for HIV Infections
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05430490's enrollment target sits among peer trials
320 110th of 542 higher than 432 of 542 other HIV Infections trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other HIV Infections trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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