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ClinicalTrials.gov 35 recruiting now official registry

Breast Neoplasms clinical trials

35 of 98 indexed Breast Neoplasms trials are currently recruiting.

98 US clinical trials · 35 currently recruiting

Breast Neoplasms is the subject of 98 registered US clinical trials on ClinicalTrials.gov, 35 of them currently open to new participants. 20 are in Phase 3-4 (later-stage) and 51 in Phase 1-2 (earlier-stage). The most active sponsor is Pfizer, running 10 of these trials.

The research picture

Breast Neoplasms has 98 registered US clinical trials, 35 of them open to new participants right now, about 36% of the total.

35
recruiting participants now
36%
of trials open to enrollment
20
in Phase 3–4 (later-stage)
10
top sponsor: Pfizer
Phase 129Phase 222Phase 319Phase 41

Active & Recent Trials

98 total, page 2 of 2

ACTIVE NOT RECRUITING Phase 1 134 participants

A Phase 1 Study of ATV-1601 in Patients With Advanced Cancer That Have AKT1 E17K Mutations

Atavistik Bio

NCT07038369

ACTIVE NOT RECRUITING 125 participants

Multi-Institutional Transgender & Gender-Diverse Breast Cancer Study

Medical College of Wisconsin

NCT06234488

ACTIVE NOT RECRUITING Phase 2 84 participants

PD 0332991 and Anastrozole for Stage 2 or 3 Estrogen Receptor Positive and HER2 Negative Breast Cancer

Washington University School of Medicine

NCT01723774

ACTIVE NOT RECRUITING 68 participants

Study of the Safety of MRI Scans in People Who Have Breast Tissue Expanders After Mastectomy

Memorial Sloan Kettering Cancer Center

NCT04769960

ACTIVE NOT RECRUITING Phase 1 44 participants

Anastrozole, Palbociclib, Trastuzumab and Pertuzumab in HR-positive, HER2-positive Metastatic Breast

Icahn School of Medicine at Mount Sinai

NCT03304080

ACTIVE NOT RECRUITING Phase 2 40 participants

Tolerability of the Combination of Lapatinib and Trastuzumab in Adults Age 60 or Older With HER2 Positive Locally Advanced or Metastatic Breast Cancer

City of Hope Medical Center

NCT01273610

ACTIVE NOT RECRUITING Phase 1 34 participants

Trial of Ibrutinib Plus Trastuzumab in HER2-amplified Metastatic Breast Cancer

US Oncology Research

NCT03379428

ACTIVE NOT RECRUITING Phase 1 31 participants

A Study of H3B-6545 in Combination With Palbociclib in Women With Advanced or Metastatic Estrogen Receptor-Positive Human Epidermal Growth Factor Receptor-2 (HER2)-Negative Breast Cancer

Eisai

NCT04288089

ACTIVE NOT RECRUITING Phase 2 12 participants

Pembrolizumab, IRX-2, and Chemotherapy in Triple Negative Breast Cancer

Providence Health & Services

NCT04373031

COMPLETED Phase 3 10,000 participants

Raloxifene Use for The Heart

Eli Lilly and Company

NCT00190593

COMPLETED 1,772 participants

A Study to Understand About the Study Medicine Palbociclib in Breast Cancer Patients After it is Out in the Japanese Market

Pfizer

NCT07096024

COMPLETED Phase 3 865 participants

Phase III Study of Atamestane Plus Toremifene Versus Letrozole in Advanced Breast Cancer

Intarcia Therapeutics

NCT00044291

COMPLETED Phase 3 594 participants

Study Of Sunitinib In Combination With Docetaxel Vs Docetaxel In Patients With Advanced Breast Cancer

Pfizer

NCT00393939

COMPLETED Phase 3 488 participants

A Study Of SU011248 Plus Paclitaxel Versus Bevacizumab Plus Paclitaxel In Patients With Advanced Breast Cancer

Pfizer

NCT00373256

COMPLETED Phase 3 444 participants

A Study Evaluating Trastuzumab Emtansine Plus Pertuzumab Compared With Chemotherapy Plus Trastuzumab and Pertuzumab for Participants With Human Epidermal Growth Factor Receptor 2 (HER2)-Positive Breast Cancer

Hoffmann-La Roche

NCT02131064

COMPLETED Phase 3 431 participants

A Study Evaluating Talazoparib (BMN 673), a PARP Inhibitor, in Advanced and/or Metastatic Breast Cancer Patients With BRCA Mutation (EMBRACA Study)

Pfizer

NCT01945775

COMPLETED NA 224 participants

A Study to Determine the Clinical Significance of Molecular Detection of Breast Cancer in the Blood of Stage IV Breast Cancer Patients

Washington University School of Medicine

NCT00355316

COMPLETED NA 191 participants

Hypnosis to Reduce Aromatase Inhibitor Pain and Improve Adherence

Icahn School of Medicine at Mount Sinai

NCT02657993

COMPLETED Phase 1 174 participants

AG-013736 In Combination With Docetaxel Versus Docetaxel Alone For Patients With Metastatic Breast Cancer

Pfizer

NCT00076024

COMPLETED NA 151 participants

Nuevo Amanecer: Promoting the Psychosocial Health of Latinas

University of California, San Francisco

NCT01383174

COMPLETED Phase 1 144 participants

A Study of Multiple Immunotherapy-Based Treatment Combinations in Hormone Receptor (HR)-Positive Human Epidermal Growth Factor Receptor 2 (HER2)-Negative Breast Cancer

Hoffmann-La Roche

NCT03280563

COMPLETED Phase 1 133 participants

This Study in Patients With Different Types of Cancer (Solid Tumours) Aims to Find a Safe Dose of Xentuzumab in Combination With Abemaciclib With or Without Hormonal Therapies. The Study Also Tests How Effective These Medicines Are in Patients With Lung and Breast Cancer

Boehringer Ingelheim

NCT03099174

COMPLETED NA 107 participants

Contrast Enhanced Mammography in Diagnosing Patients With Suspicious Breast Findings

Thomas Jefferson University

NCT03929783

COMPLETED Phase 1 106 participants

A Dose-escalation, Expansion Study of ARX788, in Advanced Solid Tumors Subjects With HER2 Expression (ACE-Pan Tumor 01)

Ambrx

NCT03255070

COMPLETED Early Phase 1 100 participants

Testing of Different Methods for Determining Whether Breast Cancer Has Spread to the Lymph Nodes

Washington University School of Medicine

NCT00360152

COMPLETED NA 100 participants

Efficacy Study of an Educational Program for Decision Support for Breast Cancer

Baylor College of Medicine

NCT00473096

COMPLETED Phase 2 90 participants

Study Of The Efficacy And Safety Of SU-014813 In Patients With Metastatic Breast Cancer

Pfizer

NCT00322517

COMPLETED Phase 1 79 participants

Study of Safety and Efficacy of Alpelisib With Everolimus or Alpelisib With Everolimus and Exemestane in Advanced Breast Cancer Patients, Renal Cell Cancer and Pancreatic Tumors

Novartis Pharmaceuticals

NCT02077933

COMPLETED Phase 2 79 participants

Bevacizumab Given With Either Anastrozole or Fulvestrant With Trastuzumab for Postmenopausal Metastatic Breast Cancer

SCRI Development Innovations

NCT00405938

COMPLETED NA 79 participants

Evaluating and Comparing Two Surgical Methods for Treatment of Early Stage Breast Cancer

Emory University

NCT01271738

COMPLETED Early Phase 1 79 participants

Using Hyperpolarized [1-13C]Pyruvate to Detect Cardiotoxicity

University of Texas Southwestern Medical Center

NCT03685175

COMPLETED 78 participants

Use of Dynamic Contrast-Enhanced Magnetic Resonance Imaging to Assess Tumor-Associated Vasculature in Patients With Metastatic Breast Cancer

National Institute of Neurological Disorders and Stroke (NINDS)

NCT00071357

COMPLETED Phase 3 65 participants

A Prospective, Randomized, Phase III Trial of FLAC (5-Fluorouracil, Leucovorin, Adriamycin, Cytoxan) Chemotherapy With GM-CSF (Granulocyte-Macrophage Colony-Stimulating Factor) Versus PIXY 321 in Advanced Breast Cancer

National Cancer Institute (NCI)

NCT00001338

COMPLETED Phase 2 60 participants

Phase 2 Study of TLK286 in Metastatic Breast Cancer

Telik

NCT00035841

COMPLETED Phase 1 58 participants

Vaccination of High Risk Breast Cancer Patients

University of Arkansas

NCT02229084

COMPLETED Phase 2 46 participants

Exemestane and Celecoxib in Postmenopausal Women at High Risk for Breast Cancer

Georgetown University

NCT00073073

COMPLETED Phase 1 42 participants

Study of XL147 (SAR245408) in Combination With Trastuzumab or Paclitaxel and Trastuzumab in Subjects With Metastatic Breast Cancer Who Have Progressed on a Previous Trastuzumab-based Regimen

Sanofi

NCT01042925

COMPLETED Phase 2 41 participants

Enzastaurin For Breast Cancer Patients Who Previously Received an Anthracycline and a Taxane Chemotherapy

Eli Lilly and Company

NCT00386087

COMPLETED NA 40 participants

Know Your Risk: Assessment at Screening for Breast Cancer - Pilot Study

Columbia University

NCT02954900

COMPLETED 33 participants

Treatment Patterns and Clinical Outcomes Among Talazoparib-Treated Adults With HER2-Negative mBC With gBRCA1/2m

Pfizer

NCT05141708

COMPLETED Phase 2 31 participants

PF-3512676 (CPG 7909) Injection For Patients Who Completed An Oncology Study Using PF-3512676 (CPG 7909)

Pfizer

NCT00043368

COMPLETED Phase 2 30 participants

Phase II Study to Evaluate Tariquidar (XR9576), a Selective MDR-1 Inhibitor, in Chemotherapy Resistant Advanced Breast Cancer

QLT

NCT00048633

COMPLETED Phase 2 26 participants

Afatinib (BIBW2992) in HER2 (Human Epidermal Growth Factor Receptor 2)-Overexpressing Inflammatory Breast Cancer

Boehringer Ingelheim

NCT01325428

COMPLETED Phase 1 25 participants

Study of Motexafin Gadolinium and Docetaxel for Advanced Cancer

Pharmacyclics

NCT00120939

COMPLETED 20 participants

Ultrasound Targeting for the Lumpectomy Cavity

University of Iowa

NCT00583843

COMPLETED Phase 1 19 participants

Bright Light on Fatigue in Women Being Treated for Breast Cancer

Washington University School of Medicine

NCT02658708

COMPLETED 13 participants

Studying Normal Breast Tissue and Cancer Risk

National Cancer Institute (NCI)

NCT00341692

COMPLETED Phase 1 9 participants

Evaluating the T Cell Response to a Peptide-based Vaccine in Patients With Breast Cancer

Craig L Slingluff, Jr

NCT00892567

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Phase Distribution

PhaseTrial count
Phase 1 29
Phase 2 22
Phase 3 19
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Breast Neoplasms Trial Landscape

98 indexed Breast Neoplasms studies · 35 recruiting (36%).

Phase mix: 20 late (III/IV) vs 51 early (I/II).

Top sponsor: Pfizer (10 trials), 9 others listed. 48 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Breast Neoplasms?

PlainTrial tracks 98 US clinical trials for Breast Neoplasms, of which 35 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Breast Neoplasms?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.