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NCT00288119 · ClinicalTrials.gov registry record

Genetic Determinants of Barrett's Esophagus and Esophageal Adenocarcinoma

A clinical trial of Barrett's Esophagus and Esophageal Neoplasm, sponsored by Case Western Reserve University.

Recruiting
Registry status
2,000
Enrollment target
10
Study locations

NCT00288119: Recruiting study of Barrett's Esophagus and Esophageal Neoplasm, sponsored by Case Western Reserve University.

NCT00288119 is a study of Barrett's Esophagus and Esophageal Neoplasm that is actively recruiting participants, run by Case Western Reserve University. The registered enrollment target is 2,000 participants, above the 433-participant average among 22 other Barrett's Esophagus trials with a reported enrollment target (362% higher). The trial reports 10 study locations across 8 states. According to ClinicalTrials.gov, the official US trial registry.

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The verdict

NCT00288119, a study of Barrett's Esophagus and Esophageal Neoplasm, is actively recruiting participants, sponsored by Case Western Reserve University.

RECRUITING
Registry status
2,000 participants
Enrollment target
10
Study locations

Study Summary

The overall objectives of this BETRNet Research Center (RC) are: 1. to conduct a rigorous, integrated spectrum of transdisciplinary human research in Barrett's esophagus (BE) and esophageal adenocarcinoma (ECA) 2. to increase the biological understanding of key observations made by our clinical researchers; 3. to translate knowledge derived from genetic, epigenetic, and transcriptome research to solving clinical dilemmas in detection, prognosis, prevention, and therapy of BE in order to prevent EAC and improve the outcomes of EAC; 4. to foster a transdisciplinary and translation research culture and to effectively expand and enhance scientific research focused on BE and EAC; 5. to evaluate research and transdisciplinary programs and to continuously improve research, productivity and enhance translational implementation. These objectives build and synergize on existing multi-institutional collaborative networks and the considerable clinical, basic science, and translational expertise available at our institutions, focusing on improving the outcomes of patients with BE and EAC. The overarching organization framework for this RC proposal is 1) to focus laboratory research on understanding the genetic susceptibility, genomic and epigenetic changes that influence the development of BE and EAC; and 2) to then translate laboratorydiscoveries into clinical applications for effective detection, molecular risk stratification, and prevention of progression from BE to EAC.

Primary Outcome

The Balloon tip is collected and sent to the PacificDx Laboratory in Irvine California to test for DNA extraction

Conditions Studied

Barrett's Esophagus Esophageal Neoplasm

Interventions

  • DEVICE Balloon Capsule Device
  • PROCEDURE Endoscopy

Study Locations (10)

Ohio

  • University Hospitals of Cleveland - Cleveland
  • Cleveland Clinic - Cleveland

Washington

  • VA Puget Sound Health Care System - Seattle
  • Fred Hutchinson Cancer Research Center, UWMC - Seattle

Maryland

  • Johns Hopkins Hospital - Baltimore

Minnesota

  • Mayo Clinic - Rochester

Missouri

  • Washington University School of Medicine - St Louis

New York

  • Columbia University Medical Center - New York

North Carolina

  • University of North Carolina at Chapel Hill - Chapel Hill

Pennsylvania

  • University of Pennsylvania - Philadelphia

Trial Details

FieldValue
Enrollment Target 2,000 participants
Start Date 2005-10-01
Est. Completion 2028-07-31
Case Western Reserve University

141 total trials

What NCT00288119 shows while recruiting

NCT00288119 is an observational study that tracks outcomes without assigning an intervention. Its 2,000 participants enrollment target places it among the larger protocols in the corpus, above the 433-participant average among 22 other Barrett's Esophagus trials with a reported enrollment target (362% higher).

The record links to 2 conditions, with Barrett's Esophagus appearing as the primary indexed condition, and to 2 interventions - of which Balloon Capsule Device is the first listed.

NCT00288119 lists 10 locations in 8 states (Ohio, Washington, Maryland).

Frequently Asked Questions

What is clinical trial NCT00288119 about?

NCT00288119 is a clinical study titled "Genetic Determinants of Barrett's Esophagus and Esophageal Adenocarcinoma". The overall objectives of this BETRNet Research Center (RC) are: 1. to conduct a rigorous, integrated spectrum of transdisciplinary human research in Barrett's esophagus (BE) and esophageal adenocarcinoma (ECA) 2. to increase the biological understanding of key observations made by our clinical res...

What is the current status of trial NCT00288119?

This trial is currently recruiting. The enrollment target is 2,000 participants. The study started on 2005-10-01. Estimated completion is 2028-07-31.

What conditions does trial NCT00288119 study?

This clinical trial studies the following conditions: Barrett's Esophagus, Esophageal Neoplasm.

What interventions are being tested in trial NCT00288119?

The interventions under investigation include: Balloon Capsule Device (DEVICE), Endoscopy (PROCEDURE).

Who is sponsoring clinical trial NCT00288119?

This trial is sponsored by Case Western Reserve University, which has 141 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT00288119 being conducted?

This trial has 10 study locations across Maryland, Minnesota, Missouri, New York, North Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Learn More About Clinical Trials

Similar trials for Barrett's Esophagus

Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.

Where NCT00288119's enrollment target sits among peer trials

2,000 3rd of 22 higher than 20 of 22 other Barrett's Esophagus trials

participants (enrollment target), bucketed by value

Each bar is a band; taller bars hold more other Barrett's Esophagus trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.

Source ClinicalTrials.gov registry export · 2026-08-08

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More recruiting context for NCT00288119

Source: ClinicalTrials.gov NCT00288119, the US trial registry maintained by the National Library of Medicine. NCT00288119 (large enrollment · multi site footprint · recruiting) retrieved and formatted by PlainTrial, see methodology.