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ClinicalTrials.gov 23 recruiting now official registry

Attention Deficit Hyperactivity Disorder clinical trials

23 of 89 indexed Attention Deficit Hyperactivity Disorder trials are currently recruiting.

89 US clinical trials · 23 currently recruiting

Attention Deficit Hyperactivity Disorder is the subject of 89 registered US clinical trials on ClinicalTrials.gov, 23 of them currently open to new participants. 21 are in Phase 3-4 (later-stage) and 19 in Phase 1-2 (earlier-stage). The most active sponsor is Massachusetts General Hospital, running 8 of these trials.

The research picture

Attention Deficit Hyperactivity Disorder has 89 registered US clinical trials, 23 of them open to new participants right now, about 26% of the total.

23
recruiting participants now
26%
of trials open to enrollment
21
in Phase 3–4 (later-stage)
8
top sponsor: Massachusetts General Hospital
Phase 17Phase 212Phase 37Phase 414

Active & Recent Trials

89 total, page 2 of 2

COMPLETED NA 113 participants

Helping College Students With ADHD Lead Healthier Lifestyles

University of Maryland, College Park

NCT02829970

COMPLETED Phase 4 105 participants

Bupropion for ADHD in Adolescents With Substance Use Disorder

University of Colorado, Denver

NCT00936299

COMPLETED NA 85 participants

New Technologies to Help Manage ADHD

Children's Hospital Medical Center, Cincinnati

NCT02390791

COMPLETED NA 84 participants

Cognitive ADHD Videogame Exploratory Study

Akili Interactive Labs

NCT01943539

COMPLETED NA 73 participants

dHealth Solution for Improving Parent Adherence to Behavioral Treatment for ADHD

University of California, San Francisco

NCT04025814

COMPLETED Phase 4 71 participants

Diagnostic Utility of Attention Deficit Hyperactivity Disorder (ADHD) by Brain Activity Flow Patterns Analysis Using Evoked Response Potentials

Massachusetts General Hospital

NCT01063153

COMPLETED NA 70 participants

Atomoxetine for Attention Deficit Hyperactivity Disorder in Adolescents With Substance Use Disorder

Denver Health and Hospital Authority

NCT00399763

COMPLETED Phase 2 69 participants

PART A: Efficacy and Safety of AEVI-001 in Children and Adolescents With ADHD and With mGluR Mutations

Aevi Genomic Medicine, LLC, a Cerecor company

NCT03265119

COMPLETED Early Phase 1 68 participants

Mindfulness-Based ADHD Treatment for Children: a Feasibility Study

Yale University

NCT04737512

COMPLETED Phase 4 62 participants

A Within-Subject Cross-Over Comparison Between Immediate Release and Extended Release Adderall

NYU Langone Health

NCT00468143

COMPLETED Phase 4 62 participants

Safety and Efficacy of Switching From a Stimulant Medication to Atomoxetine in Children and Adolescents With ADHD

Eli Lilly and Company

NCT00485875

COMPLETED NA 59 participants

Brain Plasticity Underlying Acquisition of New Organizational Skills in Children

NYU Langone Health

NCT04108273

COMPLETED Phase 4 50 participants

Naturalistic Substitution of Concerta in Adult Subject With ADHD Receiving Immediate Release Methylphenidate

Massachusetts General Hospital

NCT00302406

COMPLETED NA 44 participants

Mindful Parenting and Parent Training Program Study

New York University

NCT03796663

COMPLETED NA 42 participants

Brain Plasticity Underlying Acquisition of New Organizational Skills in Children-R61 Phase

NYU Langone Health

NCT03148782

COMPLETED Early Phase 1 40 participants

Eye Tracking as a Predictor of Methylphenidate Response in Autism With ADHD

Children's Hospital Medical Center, Cincinnati

NCT02874690

COMPLETED Phase 4 40 participants

Effectiveness and Duration of Effect of Open Treatment in Attention Deficit Hyperactivity Disorder (ADHD) Patients Treated With Lisdexamfetamine Dimesylate(Vyvanse)

NYU Langone Health

NCT01070394

COMPLETED NA 40 participants

A SMART Design to Improve Sleep Disturbance in Adolescents With Neurodevelopmental Disorders

University of Nebraska

NCT03730194

COMPLETED 38 participants

Attention-Deficit/Hyperactivity Disorder (ADHD) Brain Activity Changes to Psychostimulants

Hartford Hospital

NCT01310439

COMPLETED NA 38 participants

Transcranial Photobiomodulation Therapy for the Treatment of Autistic Traits in Children and Adolescents With ADHD

Massachusetts General Hospital

NCT04569058

COMPLETED Phase 2 38 participants

Shire SCT: Lisdexamfetamine Treatment for ADHD and SCT

NYU Langone Health

NCT02635035

COMPLETED Phase 4 36 participants

Study of Medication Patch to Treat Children Ages 6-12 With ADHD

Massachusetts General Hospital

NCT00586157

COMPLETED NA 35 participants

Text Messaging Adherence to Stimulant Medication

Massachusetts General Hospital

NCT01967485

COMPLETED NA 34 participants

Mobile Behavioral Parent Training for Childhood ADHD: A Micro-randomized Trial

Florida International University

NCT06012851

COMPLETED Phase 2 32 participants

A Safety and Effectiveness Study of JNJ-31001074 in Adults With Attention-Deficit/Hyperactivity Disorder.

Johnson & Johnson Pharmaceutical Research & Development, L.L.C.

NCT00566449

COMPLETED Phase 2 30 participants

Preschool Supplement to Clonidine in ADHD (Kiddie-CAT)

University of Cincinnati

NCT00414921

COMPLETED Phase 4 30 participants

Study of the Effects of Osmotic-Release Oral System (OROS) Methylphenidate (Concerta) on Attention and Memory

Children's Hospital of Philadelphia

NCT00530257

COMPLETED NA 28 participants

Electroencephalogram (EEG) Study of Inattention Following Treatment With AKL-T01

Akili Interactive Labs

NCT03844269

COMPLETED Phase 1 28 participants

Task-Based Grounding Program

Dartmouth-Hitchcock Medical Center

NCT04648553

COMPLETED NA 28 participants

Effects of Exercise Intensity on ADHD Symptoms

Kent State University

NCT06753253

COMPLETED NA 22 participants

Effectiveness Study of Videoconferencing on Teaching Parent Training Skills to Parents of Children With Attention Deficit Hyperactivity Disorder (ADHD)

University of California, Davis

NCT01161719

COMPLETED NA 21 participants

GroundsKeeper: A Qualitative Study of Applied Game-based Interactives in Special Education Programs

CogCubed

NCT01808066

COMPLETED Phase 2 20 participants

Study of Droxidopa Treatment in Adults With Attention Deficit Hyperactivity Disorder With Co-administration of Carbidopa

Chelsea Therapeutics

NCT00983814

COMPLETED NA 18 participants

Predictive Executive Functioning Models Using Interactive Tangible-Graphical Interface Devices in Adults

CogCubed

NCT02127931

COMPLETED Phase 1 18 participants

Lisdexamfetamine Dimesylate (LDX) Pilot Cognition Study to Evaluate the Utility of a Standardized Battery of Tests in Adults With Attention-Deficit Hyperactivity Disorder (ADHD)

Shire

NCT01010750

COMPLETED Phase 3 16 participants

A Pilot Study of Daytrana TM in Children With Autism Co-Morbid for Attention Deficit Hyperactivity Disorder (ADHD) Symptoms

University of Oklahoma

NCT00541346

COMPLETED Phase 1 14 participants

Medication Integration in Treatment of Comorbid Adolescent Substance Users/Attention Deficit Hyperactivity Disorder

The National Center on Addiction and Substance Abuse at Columbia University

NCT01369459

COMPLETED NA 12 participants

Healing Minds: Biofeedback and Breathing Practices in Children and Adolescents With ADHD

Hoskinson Health and Wellness Clinic

NCT06648252

COMPLETED Early Phase 1 6 participants

Effects of L-theanine and Caffeine on Attention and Attention-related Brain Activity of Children With Attention Deficit Hyperactivity Disorder

Texas Tech University

NCT03533556

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Phase Distribution

PhaseTrial count
Phase 1 7
Phase 2 12
Phase 3 7
Phase 4 14

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Attention Deficit Hyperactivity Disorder Trial Landscape

89 indexed Attention Deficit Hyperactivity Disorder studies · 23 recruiting (26%).

Phase mix: 21 late (III/IV) vs 19 early (I/II).

Top sponsor: Massachusetts General Hospital (8 trials), 9 others listed. 39 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Attention Deficit Hyperactivity Disorder?

PlainTrial tracks 89 US clinical trials for Attention Deficit Hyperactivity Disorder, of which 23 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Attention Deficit Hyperactivity Disorder?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.