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NCT05374187 · ClinicalTrials.gov registry record · NA

Efficacy of Trigeminal Nerve Stimulation for ADHD

A NA study of Attention Deficit Hyperactivity Disorder, sponsored by University of California, Los Angeles.

Recruiting
Registry status
NA
Development phase
280
Enrollment target
2
Study locations

NCT05374187: Recruiting NA study of Attention Deficit Hyperactivity Disorder, sponsored by University of California, Los Angeles.

NCT05374187 is a NA study of Attention Deficit Hyperactivity Disorder that is actively recruiting participants, run by University of California, Los Angeles. The registered enrollment target is 280 participants, above the 214-participant average among 102 other Attention Deficit Hyperactivity Disorder trials with a reported enrollment target (31% higher). The trial reports 2 study locations across 2 states. According to ClinicalTrials.gov, the official US trial registry.

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The verdict

NCT05374187, a NA study of Attention Deficit Hyperactivity Disorder, is actively recruiting participants, sponsored by University of California, Los Angeles.

RECRUITING
Registry status
NA
Development phase
280 participants
Enrollment target
2
Study locations

Study Summary

This study is a large multisite randomized clinical trial to asses the efficacy of external trigeminal nerve stimulation (TNS), a novel, minimal risk, non-invasive neuromodulation treatment, for ADHD in children ages 7-12 years old (N=180). Study hypotheses address potential differences in ADHD symptoms over 4 weeks treatment with active vs. sham TNS in an expanded multi-site investigation; whether resting state fronto-parietal connectivity mediates TNS impact on ADHD symptoms; if changes in fronto-parietal activation, as measured by electroencephalography (EEG), predict TNS-related treatment outcomes; and whether a baseline cognitive profile similarly predicts response to TNS therapy.

Primary Outcome

A dimensional rating of ADHD symptoms, with scores ranging from 0-54, and higher scores indicating worse outcomes.

Conditions Studied

Attention Deficit Hyperactivity Disorder

Interventions

  • DEVICE Active eTNS
  • DEVICE Sham eTNS

Study Locations (2)

California

  • University of California, Los Angeles - Los Angeles

Washington

  • Seattle Children's Hospital - Seattle

Trial Details

FieldValue
Enrollment Target 280 participants
Start Date 2022-09-01
Est. Completion 2026-01-31
Phase NA
University of California, Los Angeles

897 total trials

What NCT05374187 shows while recruiting

NCT05374187 is an interventional study that assigns participants to a tested intervention. The registered 280 participants enrollment target is mid-sized for trials with a published cap, above the 214-participant average among 102 other Attention Deficit Hyperactivity Disorder trials with a reported enrollment target (31% higher).

The record links to 1 condition, with Attention Deficit Hyperactivity Disorder appearing as the primary indexed condition, and to 2 interventions - of which Active eTNS is the first listed.

NCT05374187 reports a single indexed study location in California, Washington.

Frequently Asked Questions

What is clinical trial NCT05374187 about?

NCT05374187 is a clinical study titled "Efficacy of Trigeminal Nerve Stimulation for ADHD". This study is a large multisite randomized clinical trial to asses the efficacy of external trigeminal nerve stimulation (TNS), a novel, minimal risk, non-invasive neuromodulation treatment, for ADHD in children ages 7-12 years old (N=180). Study hypotheses address potential differences in ADHD sym...

What is the current status of trial NCT05374187?

This trial is currently recruiting. It is a NA study. The enrollment target is 280 participants. The study started on 2022-09-01. Estimated completion is 2026-01-31.

What conditions does trial NCT05374187 study?

This clinical trial studies the following conditions: Attention Deficit Hyperactivity Disorder.

What interventions are being tested in trial NCT05374187?

The interventions under investigation include: Active eTNS (DEVICE), Sham eTNS (DEVICE).

Who is sponsoring clinical trial NCT05374187?

This trial is sponsored by University of California, Los Angeles, which has 897 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT05374187 being conducted?

This trial has 2 study locations across California, Washington. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Learn More About Clinical Trials

Similar trials for Attention Deficit Hyperactivity Disorder

Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.

Where NCT05374187's enrollment target sits among peer trials

280 22nd of 102 higher than 81 of 102 other Attention Deficit Hyperactivity Disorder trials

participants (enrollment target), bucketed by value

Each bar is a band; taller bars hold more other Attention Deficit Hyperactivity Disorder trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.

Source ClinicalTrials.gov registry export · 2026-08-08

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More recruiting context for NCT05374187

Source: ClinicalTrials.gov NCT05374187, the US trial registry maintained by the National Library of Medicine. NCT05374187 (mid enrollment · single site footprint · recruiting) retrieved and formatted by PlainTrial, see methodology.