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Aortic Stenosis: early-phase trial registry
14 of 27 indexed Aortic Stenosis trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #598 of 28,707 conditions by registered trial count.
27 US clinical trials · 14 currently recruiting · #598 of 28,707 conditions by registered trial count
Aortic Stenosis: 27 US clinical trials tracked, 14 recruiting.
Aortic Stenosis is the subject of 27 registered US clinical trials on ClinicalTrials.gov, 14 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 3 in Phase 1-2 (earlier-stage). The most active sponsor is Edwards Lifesciences, running 4 of these trials.
Enrollment posture brief
Registry condition aortic-stenosis
OPEN 14 | RECR 52% | LATE 0 | EARLY 3 | RANK #598 | SPON 4
Volume-matched condition peers
Nearest open-share peer: Colorectal Carcinoma (52% recruiting · 54 trials)
Aortic Stenosis lists 14 open slots (52% of 27 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Aortic Stenosis on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Aortic Stenosis is recruiting above its size-band peers.
14 of 27 indexed trials (51.9%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Aortic Stenosis trials is spread across many organizations.
Edwards Lifesciences accounts for 4 of 27 trials (14.8%). 20 distinct sponsors appear on at least one study for this condition label.
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Typical Aortic Stenosis enrolment sits around 225 participants.
Median target enrolment is 225 among the 27 trials that report a genuine target (sentinel values excluded). 8 of those (29.6%) plan for fewer than 100 participants.
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Aortic Stenosis splits between interventional and observational designs.
17 interventional and 10 observational studies make up this index (63% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
27 total, page 1 of 1
Study of the Progression of Chronic Cardiovascular Conditions
Prolaio
NCT07420907
Staged Complete Revascularization for Coronary Artery Disease vs Medical Management Alone in Patients With AS Undergoing Transcatheter Aortic Valve Replacement
University of British Columbia
NCT04634240
AI in Outpatient Practice for Diagnosing Aortic Stenosis and Diastolic Dysfunction
Mayo Clinic
NCT06580158
A Multicenter Trial Assessing the Impact of Lipoprotein(a) Lowering With Pelacarsen (TQJ230) on the Progression of Calcific Aortic Valve Stenosis
Novartis Pharmaceuticals
NCT05646381
The HALT Biomarker Study
Massachusetts General Hospital
NCT04552275
REdo tranScatheter Aortic Valve Replacement for Transcatheter aOrtic Valve failuRE
Medtronic Cardiovascular
NCT06777368
Loss of Y Chromosome in Aortic Stenosis
University of Virginia
NCT06595407
Comparative Imaging Assessment of Valvular Heart Disease
The Cleveland Clinic
NCT04126018
Novel Characterization of Sex Specific Biologic Signatures in Valvular Heart Disease
The Cleveland Clinic
NCT06780241
PARTNER 3 Trial - Aortic Valve-in-Valve
Edwards Lifesciences
NCT03003299
Improved Outcomes With Pre-Procedure Shockwave IVL of Common Femoral Artery Access Site Prior to Large Bore Access and Pre-Closure
University of Tennessee Graduate School of Medicine
NCT07205068
Long Term Evaluation of Cardiac Arrhythmias After Transcatheter Aortic Valve Implantation -The LOCATE Registry
Kansas City Heart Rhythm Research Foundation
NCT06055751
Evaluating Infrasonic Hemodynography
Scripps Health
NCT04636892
Correlation Between an Impedance Cardiography Test for Decompensation and the Development of Left Ventricular Replacement Fibrosis
Dermed Diagnostics
NCT07230964
Genomic Investigation of Cardiovascular Diseases
Scripps Translational Science Institute
NCT00722748
ACURATE IDE: Safety and Effectiveness Study of ACURATE Valve for Transcatheter Aortic Valve Replacement
Boston Scientific Corporation
NCT03735667
PERIGON Pivotal Trial
Medtronic Cardiac Surgery
NCT02088554
PARTNER 3 Trial: Safety and Effectiveness of the SAPIEN 3 Transcatheter Heart Valve in Low Risk Patients With Aortic Stenosis
Edwards Lifesciences
NCT02675114
ProspeCtive, nOn-randoMized, MulticENter Clinical Evaluation of Edwards Pericardial Bioprostheses With a New Tissue Treatment Platform (COMMENCE)
Edwards Lifesciences
NCT01757665
Use of DurAVR™ THV System in Subjects With Severe Aortic Stenosis: Early Feasibility Study
Anteris Technologies
NCT05712161
PARTNER II Trial: S3iCAP
Edwards Lifesciences
NCT02687035
Feasibility of Transcatheter Aortic Valve Replacement in Low-Risk Patients With Symptomatic, Severe Aortic Stenosis
Medstar Health Research Institute
NCT02628899
Medtronic CoreValve Evolut R U.S. Clinical Study
Medtronic Cardiovascular
NCT02207569
Standardized Invasive Hemodynamics for Elevated Gradients Post TAVR (DISCORDANCE TAVR)
University of British Columbia
NCT04827238
Cardiac Remodeling and Circulating Biomarkers in Pediatric Left Ventricular Pressure Loading Lesions
University of Colorado, Denver
NCT02545790
The ShortCut™ Continued Access Study Protocol
Pi-cardia
NCT06211296
Prevalence of Transthyretin Cardiac Amyloidosis in Clinically Significant Aortic Stenosis
Mayo Clinic
NCT04899180
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 2 |
| Phase 2 | 1 |
Top Sponsors
Named interventions
Most-linked intervention names on Aortic Stenosis records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Aortic Stenosis trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Aortic Stenosis page
27 registered trials, 14 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 14 Aortic Stenosis trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Edwards Lifesciences sponsors the most Aortic Stenosis trials on record, review their full trial history before evaluating a specific study. See Edwards Lifesciences's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Aortic Stenosis condition card totals 27 registered trials; most-linked intervention 99mTc-PYP; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.