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Aortic Stenosis
Open-data reference.
27 US clinical trials · 14 currently recruiting
Active & Recent Trials
Study of the Progression of Chronic Cardiovascular Conditions
Prolaio
NCT07420907
Staged Complete Revascularization for Coronary Artery Disease vs Medical Management Alone in Patients With AS Undergoing Transcatheter Aortic Valve Replacement
University of British Columbia
NCT04634240
AI in Outpatient Practice for Diagnosing Aortic Stenosis and Diastolic Dysfunction
Mayo Clinic
NCT06580158
A Multicenter Trial Assessing the Impact of Lipoprotein(a) Lowering With Pelacarsen (TQJ230) on the Progression of Calcific Aortic Valve Stenosis
Novartis Pharmaceuticals
NCT05646381
The HALT Biomarker Study
Massachusetts General Hospital
NCT04552275
REdo tranScatheter Aortic Valve Replacement for Transcatheter aOrtic Valve failuRE
Medtronic Cardiovascular
NCT06777368
Loss of Y Chromosome in Aortic Stenosis
University of Virginia
NCT06595407
Comparative Imaging Assessment of Valvular Heart Disease
The Cleveland Clinic
NCT04126018
Novel Characterization of Sex Specific Biologic Signatures in Valvular Heart Disease
The Cleveland Clinic
NCT06780241
PARTNER 3 Trial - Aortic Valve-in-Valve
Edwards Lifesciences
NCT03003299
Improved Outcomes With Pre-Procedure Shockwave IVL of Common Femoral Artery Access Site Prior to Large Bore Access and Pre-Closure
University of Tennessee Graduate School of Medicine
NCT07205068
Long Term Evaluation of Cardiac Arrhythmias After Transcatheter Aortic Valve Implantation -The LOCATE Registry
Kansas City Heart Rhythm Research Foundation
NCT06055751
Evaluating Infrasonic Hemodynography
Scripps Health
NCT04636892
Correlation Between an Impedance Cardiography Test for Decompensation and the Development of Left Ventricular Replacement Fibrosis
Dermed Diagnostics
NCT07230964
Genomic Investigation of Cardiovascular Diseases
Scripps Translational Science Institute
NCT00722748
ACURATE IDE: Safety and Effectiveness Study of ACURATE Valve for Transcatheter Aortic Valve Replacement
Boston Scientific Corporation
NCT03735667
PERIGON Pivotal Trial
Medtronic Cardiac Surgery
NCT02088554
PARTNER 3 Trial: Safety and Effectiveness of the SAPIEN 3 Transcatheter Heart Valve in Low Risk Patients With Aortic Stenosis
Edwards Lifesciences
NCT02675114
ProspeCtive, nOn-randoMized, MulticENter Clinical Evaluation of Edwards Pericardial Bioprostheses With a New Tissue Treatment Platform (COMMENCE)
Edwards Lifesciences
NCT01757665
Use of DurAVR™ THV System in Subjects With Severe Aortic Stenosis: Early Feasibility Study
Anteris Technologies
NCT05712161
PARTNER II Trial: S3iCAP
Edwards Lifesciences
NCT02687035
Feasibility of Transcatheter Aortic Valve Replacement in Low-Risk Patients With Symptomatic, Severe Aortic Stenosis
Medstar Health Research Institute
NCT02628899
Medtronic CoreValve Evolut R U.S. Clinical Study
Medtronic Cardiovascular
NCT02207569
Standardized Invasive Hemodynamics for Elevated Gradients Post TAVR (DISCORDANCE TAVR)
University of British Columbia
NCT04827238
Cardiac Remodeling and Circulating Biomarkers in Pediatric Left Ventricular Pressure Loading Lesions
University of Colorado, Denver
NCT02545790
The ShortCut™ Continued Access Study Protocol
Pi-cardia
NCT06211296
Prevalence of Transthyretin Cardiac Amyloidosis in Clinically Significant Aortic Stenosis
Mayo Clinic
NCT04899180
Phase Distribution
| Phase | Trial count |
|---|---|
| Early Phase 1 | 2 |
| Phase 2 | 1 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Aortic Stenosis Trial Landscape
ClinicalTrials.gov lists 27 US studies indexed under Aortic Stenosis, and 14 of those are currently open to recruitment — roughly 52% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Aortic Stenosis shows 0 late-stage studies (Phase 3 and Phase 4 combined) alongside 3 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Aortic Stenosis is led by Edwards Lifesciences with 4 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 27 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Aortic Stenosis?
PlainTrial tracks 27 US clinical trials for Aortic Stenosis, of which 14 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Aortic Stenosis?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.