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NCT04899180 · ClinicalTrials.gov registry record · Early Phase 1

Prevalence of Transthyretin Cardiac Amyloidosis in Clinically Significant Aortic Stenosis

A Early Phase 1 study of Aortic Stenosis and Transthyretin Amyloidosis, sponsored by Mayo Clinic.

Completed
Registry status
Early Phase 1
Development phase
4
Enrollment target
1
Study location

NCT04899180: Completed Early Phase 1 study of Aortic Stenosis and Transthyretin Amyloidosis, sponsored by Mayo Clinic.

NCT04899180 is a Early Phase 1 study of Aortic Stenosis and Transthyretin Amyloidosis that has completed, run by Mayo Clinic. The registered enrollment target is 4 participants, below the 1,362-participant average among 26 other Aortic Stenosis trials with a reported enrollment target (100% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.

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The verdict

NCT04899180, a Early Phase 1 study of Aortic Stenosis and Transthyretin Amyloidosis, has completed, sponsored by Mayo Clinic.

COMPLETED
Registry status
Early Phase 1
Development phase
4 participants
Enrollment target
1
Study location

Study Summary

The purpose of this study is to determine the prevalence of transthyretin cardiac amyloidosis (TTR-CA) among patients with moderate and severe aortic stenosis in Southeast Minnesota using 99mTc-PYP single-photon positive emission computed tomography with computed tomography (SPECT/CT).

Primary Outcome

Determine the prevalence of Transthyretin Cardiac Amyloidosis in a community based cohort of consecutive patients with moderate or severe aortic stenosis using 99mTc-Pyrophosphate (99mTc-PYP) single-photon positive emission computed tomography with computed tomography (SPECT/CT)

Conditions Studied

Aortic Stenosis Transthyretin Amyloidosis Transthyretin Cardiac Amyloidosis Transthyretin Amyloid Cardiomyopathy

Interventions

  • DRUG 99mTc-PYP

Study Locations (1)

Minnesota

  • Mayo Clinic in Rochester - Rochester

Trial Details

FieldValue
Enrollment Target 4 participants
Start Date 2023-07-14
Est. Completion 2024-01-05
Phase Early Phase 1
Mayo Clinic

2,844 total trials

What the finished NCT04899180 record still lists

NCT04899180 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 4 participants, a relatively small participant target, below the 1,362-participant average among 26 other Aortic Stenosis trials with a reported enrollment target (100% lower).

The record links to 4 conditions, with Aortic Stenosis appearing as the primary indexed condition, and to 1 intervention - of which 99mTc-PYP is the first listed.

NCT04899180 reports a single indexed study location in Minnesota.

Frequently Asked Questions

What is clinical trial NCT04899180 about?

NCT04899180 is a clinical study titled "Prevalence of Transthyretin Cardiac Amyloidosis in Clinically Significant Aortic Stenosis". The purpose of this study is to determine the prevalence of transthyretin cardiac amyloidosis (TTR-CA) among patients with moderate and severe aortic stenosis in Southeast Minnesota using 99mTc-PYP single-photon positive emission computed tomography with computed tomography (SPECT/CT).

What is the current status of trial NCT04899180?

This trial is currently completed. It is a Early Phase 1 study. The enrollment target is 4 participants. The study started on 2023-07-14. Estimated completion is 2024-01-05.

What conditions does trial NCT04899180 study?

This clinical trial studies the following conditions: Aortic Stenosis, Transthyretin Amyloidosis, Transthyretin Cardiac Amyloidosis, Transthyretin Amyloid Cardiomyopathy.

What interventions are being tested in trial NCT04899180?

The interventions under investigation include: 99mTc-PYP (DRUG).

Who is sponsoring clinical trial NCT04899180?

This trial is sponsored by Mayo Clinic, which has 2,844 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT04899180 being conducted?

This trial has 1 study location across Minnesota. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Learn More About Clinical Trials

Similar trials for Aortic Stenosis

Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.

Where NCT04899180's enrollment target sits among peer trials

4 27th of 26 the lowest of 26 other Aortic Stenosis trials

participants (enrollment target), bucketed by value

Each bar is a band; taller bars hold more other Aortic Stenosis trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.

Source ClinicalTrials.gov registry export · 2026-08-08

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Related registry views

Source: ClinicalTrials.gov NCT04899180, the US trial registry maintained by the National Library of Medicine. NCT04899180 (small enrollment · single site footprint · completed) retrieved and formatted by PlainTrial, see methodology.