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NCT06595407 · ClinicalTrials.gov registry record
Loss of Y Chromosome in Aortic Stenosis
A clinical trial of Aortic Stenosis, sponsored by University of Virginia.
- Recruiting
- Registry status
- 200
- Enrollment target
- 1
- Study location
NCT06595407: Recruiting study of Aortic Stenosis, sponsored by University of Virginia.
NCT06595407 is a study of Aortic Stenosis that is actively recruiting participants, run by University of Virginia. The registered enrollment target is 200 participants, below the 1,355-participant average among 26 other Aortic Stenosis trials with a reported enrollment target (85% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06595407, a study of Aortic Stenosis, is actively recruiting participants, sponsored by University of Virginia.
- RECRUITING
- Registry status
- 200 participants
- Enrollment target
- 1
- Study location
Study Summary
The most common heart valve disease in humans is aortic stenosis which is a critical narrowing of the valve through which the heart has to pump blood to the rest of the body. This condition occurs in 2-3% of adults over 65 years of age and when it progresses to a severe stage leads to heart failure and need for valve replacement procedures (including surgery and catheter-based replacement). Aortic stenosis has a strong male predominance. The purpose of this study is to evaluate whether loss of Y-chromosome from circulating blood cells in males, which has been associated with TGF-beta-related fibrosis of other organs, is associated with the development of aortic stenosis.
Primary Outcome
This is a cross-sectional case-control study where the outcome measure is the percentage of circulating cells that have loss-of-Y chromosome
Conditions Studied
Interventions
- DIAGNOSTIC_TEST Blood analysis for loss-of-Y chromosome
Study Locations (1)
Virginia
- University of Virginia - Charlottesville
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 200 participants |
| Start Date | 2024-08-15 |
| Est. Completion | 2026-06-01 |
What NCT06595407 shows while recruiting
NCT06595407 is an observational study that tracks outcomes without assigning an intervention. The registered 200 participants enrollment target is mid-sized for trials with a published cap, below the 1,355-participant average among 26 other Aortic Stenosis trials with a reported enrollment target (85% lower).
The record links to 1 condition, with Aortic Stenosis appearing as the primary indexed condition, and to 1 intervention - of which Blood analysis for loss-of-Y chromosome is the first listed.
NCT06595407 reports a single indexed study location in Virginia.
Frequently Asked Questions
What is clinical trial NCT06595407 about?
NCT06595407 is a clinical study titled "Loss of Y Chromosome in Aortic Stenosis". The most common heart valve disease in humans is aortic stenosis which is a critical narrowing of the valve through which the heart has to pump blood to the rest of the body. This condition occurs in 2-3% of adults over 65 years of age and when it progresses to a severe stage leads to heart failure ...
What is the current status of trial NCT06595407?
This trial is currently recruiting. The enrollment target is 200 participants. The study started on 2024-08-15. Estimated completion is 2026-06-01.
What conditions does trial NCT06595407 study?
This clinical trial studies the following conditions: Aortic Stenosis.
What interventions are being tested in trial NCT06595407?
The interventions under investigation include: Blood analysis for loss-of-Y chromosome (DIAGNOSTIC_TEST).
Who is sponsoring clinical trial NCT06595407?
This trial is sponsored by University of Virginia, which has 449 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06595407 being conducted?
This trial has 1 study location across Virginia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT06595407's enrollment target sits among peer trials
200 15th of 26 higher than 10 of 26 other Aortic Stenosis trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Aortic Stenosis trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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