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Colorectal Carcinoma: early-phase trial registry
28 of 54 indexed Colorectal Carcinoma trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #261 of 28,707 conditions by registered trial count.
54 US clinical trials · 28 currently recruiting · #261 of 28,707 conditions by registered trial count
Colorectal Carcinoma: 54 US clinical trials tracked, 28 recruiting.
Colorectal Carcinoma is the subject of 54 registered US clinical trials on ClinicalTrials.gov, 28 of them currently open to new participants. 1 are in Phase 3-4 (later-stage) and 28 in Phase 1-2 (earlier-stage). The most active sponsor is National Cancer Institute (NCI), running 8 of these trials.
Enrollment posture brief
Registry condition colorectal-carcinoma
OPEN 28 | RECR 52% | LATE 1 | EARLY 28 | RANK #261 | SPON 8
Volume-matched condition peers
Nearest open-share peer: Aortic Stenosis (52% recruiting · 27 trials)
Colorectal Carcinoma lists 28 open slots (52% of 54 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Colorectal Carcinoma on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Colorectal Carcinoma is recruiting above its size-band peers.
28 of 54 indexed trials (51.9%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Colorectal Carcinoma trials is spread across many organizations.
National Cancer Institute (NCI) accounts for 8 of 54 trials (14.8%). 32 distinct sponsors appear on at least one study for this condition label.
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Typical Colorectal Carcinoma enrolment sits around 124 participants.
Median target enrolment is 124 among the 54 trials that report a genuine target (sentinel values excluded). 23 of those (42.6%) plan for fewer than 100 participants.
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Colorectal Carcinoma research is mostly interventional.
47 interventional and 7 observational studies make up this index (87% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
54 total, page 1 of 2
The Vanguard Study: Testing a New Way to Screen for Cancer
National Cancer Institute (NCI)
NCT06995898
Implementation of a ColoRectal Cancer Screening Tool in US Primary Care Practices - Usual Quality Improvement (10 Clinics) vs Normalization Process Theory-Participatory Learning in Action (10 Clinics)
University of Kansas Medical Center
NCT06682650
The Ohio State University (OSU) SCREEN Community Program
Ohio State University Comprehensive Cancer Center
NCT06666192
Assessing Benefits and Harms of Cannabis/Cannabinoid Use Among Cancer Patients Treated in Community Oncology Clinics
Wake Forest University Health Sciences
NCT06418204
Improving Colonoscopy Surveillance for Patients With High Risk Colon Polyps
Jonsson Comprehensive Cancer Center
NCT06376565
A Clinic-wide Intervention (Primary Care-GI Connect) for Improving Rates of Colonoscopy After Abnormal Fecal Immunochemical Test Result in Patients at Federally Qualified Health Centers
Jonsson Comprehensive Cancer Center
NCT06568016
Collection of Information to Better Understand Young Onset Colorectal Cancer
Memorial Sloan Kettering Cancer Center
NCT04489238
Collecting Blood and Stool Samples to Detect Colorectal Cancer or Advanced Neoplasia in Lynch Syndrome Patients
Mayo Clinic
NCT05410977
Confronting Cancer as a Community
University of Southern California
NCT06063928
Addressing Disparities in Colorectal Cancer Screening in Black and Underserved Phoenix Communities
Mayo Clinic
NCT05447923
Study of CP-383 in Patients With Advanced or Metastatic Solid Tumors
Tasca Therapeutics
NCT07030257
Tegavivint for the Treatment of Recurrent or Refractory Solid Tumors, Including Lymphomas and Desmoid Tumors
Children's Oncology Group
NCT04851119
CoGENES Randomized Controlled Trial (RCT)
University of Southern California
NCT07229443
A Study to Test Different Doses of BI 765049 in People With Advanced Cancer of the Colon, Rectum, Stomach, or Pancreas
Boehringer Ingelheim
NCT06882746
Study of JANX008 in Subjects With Advanced or Metastatic Solid Tumor Malignancies
Janux Therapeutics
NCT05783622
A Study of MGC028 in Participants With Advanced Solid Tumors
MacroGenics
NCT06723236
Changes in Reproductive and Sexual Health in People With Early Onset Colorectal Cancer
Memorial Sloan Kettering Cancer Center
NCT04812912
Phase 1 Study to Investigate TCRTs KRAS Mutation in Unresectable, Advanced, and/or Metastatic Solid Tumors
AstraZeneca
NCT06218914
Culturally Adapting an Intervention to Increase Genetic Testing in African American Cancer Survivors
Barbara Ann Karmanos Cancer Institute
NCT07436078
A Self-Monitoring Platform for Tracking Medication Safety and Concerns in Cancer Patients
University of Michigan Rogel Cancer Center
NCT07291414
A Web-Based Dyadic Intervention for Colorectal Cancer
Emory University
NCT05663203
A Study of NT-175 in Adult Subjects With Unresectable, Advanced, and/or Metastatic Solid Tumors That Are Positive for HLA-A*02:01 and the TP53 R175H Mutation
AstraZeneca
NCT05877599
Testing for Safety and Colorectal Cancer Preventive Effects of ONC201
National Cancer Institute (NCI)
NCT05630794
Determining the Biodistribution of an Imaging Tracer (68Ga-FAPi-46) in Patients With Solid Tumors or Hematologic Cancers
Jonsson Comprehensive Cancer Center
NCT07118176
Role of Diet on the Microbiome of the Digestive System
M.D. Anderson Cancer Center
NCT04666727
Evaluating the Effects of an Exercise Intervention on the Gut Microbiota in Stage II-III Colorectal Cancer Survivors
Fred Hutchinson Cancer Center
NCT05930496
The Cancer Connected Access and Remote Expertise Beyond Walls Program to Provide In-Home Cancer Treatment and Improve Treatment Satisfaction in Cancer Patients Living in the Florida Panhandle and Surrounding Areas
Mayo Clinic
NCT07285044
Immune Response Activation for the Treatment of Unresectable Metastatic Colorectal Cancer or CEA Positive Metastatic Breast Cancer
City of Hope Medical Center
NCT06130826
Implementation Research to Increase Colorectal Cancer Screening Rates Among Low Income and Ethnic Minority Groups
Jonsson Comprehensive Cancer Center
NCT06090643
Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial)
National Cancer Institute (NCI)
NCT02465060
Young-Onset Colorectal Cancer
M.D. Anderson Cancer Center
NCT02863107
HOPE-Genomics Intervention for the Improvement of Cancer Patient Knowledge of Genomics
City of Hope Medical Center
NCT04905082
Survivorship Care Plans and Telehealth Education for the Improvement of Access to Cancer Survivorship, the IMPACT Study
Fred Hutchinson Cancer Center
NCT04081779
Testing a Combination of Vaccines for Cancer Prevention in Lynch Syndrome
National Cancer Institute (NCI)
NCT05419011
Lesion Detection Assessment in the Liver: Standard vs Low Radiation Dose Using Varied Post-Processing Techniques
M.D. Anderson Cancer Center
NCT03151564
Study of NGM831 as Monotherapy and in Combination With Pembrolizumab or Pembrolizumab and NGM438 in Advanced or Metastatic Solid Tumors
NGM Biopharmaceuticals
NCT05215574
Vaccine Therapy in Treating Patients With Newly Diagnosed Advanced Colon Polyps
National Cancer Institute (NCI)
NCT02134925
Aspirin in Preventing Colorectal Cancer in Patients With Colorectal Adenoma
National Cancer Institute (NCI)
NCT02965703
Platform Study of JDQ443 in Combinations in Patients With Advanced Solid Tumors Harboring the KRAS G12C Mutation
Novartis Pharmaceuticals
NCT05358249
Cancer Preventive Vaccine Nous-209 for Lynch Syndrome Patients
National Cancer Institute (NCI)
NCT05078866
Testing Atorvastatin to Lower Colon Cancer Risk in Longstanding Ulcerative Colitis
Northwestern University
NCT04767984
Tucatinib Plus Trastuzumab and Oxaliplatin-based Chemotherapy or Pembrolizumab-containing Combinations for HER2+ Gastrointestinal Cancers
Seagen, a wholly owned subsidiary of Pfizer
NCT04430738
First-in-Human Positron Emission Tomography Study Using the 18F-αvβ6-Binding-Peptide
Julie L. Sutcliffe, Ph.D
NCT03164486
Community Genetic Navigation Engagement Specialists to Increase Knowledge About Colorectal Cancer Genetics in Hispanic/Latino/a Communities
University of Southern California
NCT07276048
Study of Cabozantinib Plus TAS102 in mCRC as Salvage Therapy
University of California, Irvine
NCT04868773
Multicenter Randomized Parallel Group Phase III Study Comparing the Bowel Cleansing Efficacy, Safety and Tolerability of NER1006 Versus Trisulfate Solution Using 2-Day Split-Dosing Regimen in Adults
Norgine
NCT02254486
Comprehensive Electronic Cancer Support System for the Treatment of Cancer Related Symptoms
University of Pittsburgh
NCT01640522
A Study of XmAb®20717 in Subjects With Selected Advanced Solid Tumors
Xencor
NCT03517488
A Safety, Pharmacokinetic and Efficacy Study of NUC-3373 in Combination With Standard Agents Used in Colorectal Cancer Treatment
NuCana
NCT03428958
Phase 1 Study of MGD007 in Relapsed/Refractory Metastatic Colorectal Carcinoma
MacroGenics
NCT02248805
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 19 |
| Phase 2 | 9 |
| Phase 3 | 1 |
Top Sponsors
Named interventions
Most-linked intervention names on Colorectal Carcinoma records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Colorectal Carcinoma trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Colorectal Carcinoma page
54 registered trials, 28 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 28 Colorectal Carcinoma trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- National Cancer Institute (NCI) sponsors the most Colorectal Carcinoma trials on record, review their full trial history before evaluating a specific study. See National Cancer Institute (NCI)'s trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Colorectal Carcinoma condition card totals 54 registered trials; most-linked intervention Biospecimen Collection; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.