Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

2026 data Public-data reference. official source

Colorectal Carcinoma

Open-data reference.

54 US clinical trials · 28 currently recruiting

Active & Recent Trials

RECRUITING NA 24,000 participants

The Vanguard Study: Testing a New Way to Screen for Cancer

National Cancer Institute (NCI)

NCT06995898

RECRUITING NA 2,200 participants

Implementation of a ColoRectal Cancer Screening Tool in US Primary Care Practices - Usual Quality Improvement (10 Clinics) vs Normalization Process Theory-Participatory Learning in Action (10 Clinics)

University of Kansas Medical Center

NCT06682650

RECRUITING NA 2,067 participants

The Ohio State University (OSU) SCREEN Community Program

Ohio State University Comprehensive Cancer Center

NCT06666192

RECRUITING 2,000 participants

Assessing Benefits and Harms of Cannabis/Cannabinoid Use Among Cancer Patients Treated in Community Oncology Clinics

Wake Forest University Health Sciences

NCT06418204

RECRUITING NA 1,680 participants

Improving Colonoscopy Surveillance for Patients With High Risk Colon Polyps

Jonsson Comprehensive Cancer Center

NCT06376565

RECRUITING NA 1,500 participants

A Clinic-wide Intervention (Primary Care-GI Connect) for Improving Rates of Colonoscopy After Abnormal Fecal Immunochemical Test Result in Patients at Federally Qualified Health Centers

Jonsson Comprehensive Cancer Center

NCT06568016

RECRUITING 1,366 participants

Collection of Information to Better Understand Young Onset Colorectal Cancer

Memorial Sloan Kettering Cancer Center

NCT04489238

RECRUITING 750 participants

Collecting Blood and Stool Samples to Detect Colorectal Cancer or Advanced Neoplasia in Lynch Syndrome Patients

Mayo Clinic

NCT05410977

RECRUITING NA 500 participants

Confronting Cancer as a Community

University of Southern California

NCT06063928

RECRUITING NA 450 participants

Addressing Disparities in Colorectal Cancer Screening in Black and Underserved Phoenix Communities

Mayo Clinic

NCT05447923

RECRUITING Phase 1 150 participants

Study of CP-383 in Patients With Advanced or Metastatic Solid Tumors

Tasca Therapeutics

NCT07030257

RECRUITING Phase 1 147 participants

Tegavivint for the Treatment of Recurrent or Refractory Solid Tumors, Including Lymphomas and Desmoid Tumors

Children's Oncology Group

NCT04851119

RECRUITING NA 140 participants

CoGENES Randomized Controlled Trial (RCT)

University of Southern California

NCT07229443

RECRUITING Phase 1 135 participants

A Study to Test Different Doses of BI 765049 in People With Advanced Cancer of the Colon, Rectum, Stomach, or Pancreas

Boehringer Ingelheim

NCT06882746

RECRUITING Phase 1 130 participants

Study of JANX008 in Subjects With Advanced or Metastatic Solid Tumor Malignancies

Janux Therapeutics

NCT05783622

RECRUITING Phase 1 124 participants

A Study of MGC028 in Participants With Advanced Solid Tumors

MacroGenics

NCT06723236

RECRUITING 120 participants

Changes in Reproductive and Sexual Health in People With Early Onset Colorectal Cancer

Memorial Sloan Kettering Cancer Center

NCT04812912

RECRUITING Phase 1 108 participants

Phase 1 Study to Investigate TCRTs KRAS Mutation in Unresectable, Advanced, and/or Metastatic Solid Tumors

AstraZeneca

NCT06218914

RECRUITING NA 85 participants

Culturally Adapting an Intervention to Increase Genetic Testing in African American Cancer Survivors

Barbara Ann Karmanos Cancer Institute

NCT07436078

RECRUITING NA 80 participants

A Self-Monitoring Platform for Tracking Medication Safety and Concerns in Cancer Patients

University of Michigan Rogel Cancer Center

NCT07291414

RECRUITING NA 56 participants

A Web-Based Dyadic Intervention for Colorectal Cancer

Emory University

NCT05663203

RECRUITING Phase 1 46 participants

A Study of NT-175 in Adult Subjects With Unresectable, Advanced, and/or Metastatic Solid Tumors That Are Positive for HLA-A*02:01 and the TP53 R175H Mutation

AstraZeneca

NCT05877599

RECRUITING Phase 1 36 participants

Testing for Safety and Colorectal Cancer Preventive Effects of ONC201

National Cancer Institute (NCI)

NCT05630794

RECRUITING Phase 1 30 participants

Determining the Biodistribution of an Imaging Tracer (68Ga-FAPi-46) in Patients With Solid Tumors or Hematologic Cancers

Jonsson Comprehensive Cancer Center

NCT07118176

RECRUITING 30 participants

Role of Diet on the Microbiome of the Digestive System

M.D. Anderson Cancer Center

NCT04666727

RECRUITING NA 30 participants

Evaluating the Effects of an Exercise Intervention on the Gut Microbiota in Stage II-III Colorectal Cancer Survivors

Fred Hutchinson Cancer Center

NCT05930496

RECRUITING Phase 2 27 participants

The Cancer Connected Access and Remote Expertise Beyond Walls Program to Provide In-Home Cancer Treatment and Improve Treatment Satisfaction in Cancer Patients Living in the Florida Panhandle and Surrounding Areas

Mayo Clinic

NCT07285044

RECRUITING Phase 1 24 participants

Immune Response Activation for the Treatment of Unresectable Metastatic Colorectal Cancer or CEA Positive Metastatic Breast Cancer

City of Hope Medical Center

NCT06130826

ACTIVE NOT RECRUITING NA 9,745 participants

Implementation Research to Increase Colorectal Cancer Screening Rates Among Low Income and Ethnic Minority Groups

Jonsson Comprehensive Cancer Center

NCT06090643

ACTIVE NOT RECRUITING Phase 2 6,452 participants

Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial)

National Cancer Institute (NCI)

NCT02465060

ACTIVE NOT RECRUITING 818 participants

Young-Onset Colorectal Cancer

M.D. Anderson Cancer Center

NCT02863107

ACTIVE NOT RECRUITING NA 465 participants

HOPE-Genomics Intervention for the Improvement of Cancer Patient Knowledge of Genomics

City of Hope Medical Center

NCT04905082

ACTIVE NOT RECRUITING NA 261 participants

Survivorship Care Plans and Telehealth Education for the Improvement of Access to Cancer Survivorship, the IMPACT Study

Fred Hutchinson Cancer Center

NCT04081779

ACTIVE NOT RECRUITING Phase 2 186 participants

Testing a Combination of Vaccines for Cancer Prevention in Lynch Syndrome

National Cancer Institute (NCI)

NCT05419011

ACTIVE NOT RECRUITING NA 146 participants

Lesion Detection Assessment in the Liver: Standard vs Low Radiation Dose Using Varied Post-Processing Techniques

M.D. Anderson Cancer Center

NCT03151564

ACTIVE NOT RECRUITING Phase 1 130 participants

Study of NGM831 as Monotherapy and in Combination With Pembrolizumab or Pembrolizumab and NGM438 in Advanced or Metastatic Solid Tumors

NGM Biopharmaceuticals

NCT05215574

ACTIVE NOT RECRUITING Phase 2 110 participants

Vaccine Therapy in Treating Patients With Newly Diagnosed Advanced Colon Polyps

National Cancer Institute (NCI)

NCT02134925

ACTIVE NOT RECRUITING Phase 2 81 participants

Aspirin in Preventing Colorectal Cancer in Patients With Colorectal Adenoma

National Cancer Institute (NCI)

NCT02965703

ACTIVE NOT RECRUITING Phase 1 74 participants

Platform Study of JDQ443 in Combinations in Patients With Advanced Solid Tumors Harboring the KRAS G12C Mutation

Novartis Pharmaceuticals

NCT05358249

ACTIVE NOT RECRUITING Phase 1 45 participants

Cancer Preventive Vaccine Nous-209 for Lynch Syndrome Patients

National Cancer Institute (NCI)

NCT05078866

ACTIVE NOT RECRUITING Phase 2 42 participants

Testing Atorvastatin to Lower Colon Cancer Risk in Longstanding Ulcerative Colitis

Northwestern University

NCT04767984

ACTIVE NOT RECRUITING Phase 2 40 participants

Tucatinib Plus Trastuzumab and Oxaliplatin-based Chemotherapy or Pembrolizumab-containing Combinations for HER2+ Gastrointestinal Cancers

Seagen, a wholly owned subsidiary of Pfizer

NCT04430738

ACTIVE NOT RECRUITING Early Phase 1 27 participants

First-in-Human Positron Emission Tomography Study Using the 18F-αvβ6-Binding-Peptide

Julie L. Sutcliffe, Ph.D

NCT03164486

ACTIVE NOT RECRUITING NA 20 participants

Community Genetic Navigation Engagement Specialists to Increase Knowledge About Colorectal Cancer Genetics in Hispanic/Latino/a Communities

University of Southern California

NCT07276048

ACTIVE NOT RECRUITING Phase 1 12 participants

Study of Cabozantinib Plus TAS102 in mCRC as Salvage Therapy

University of California, Irvine

NCT04868773

COMPLETED Phase 3 621 participants

Multicenter Randomized Parallel Group Phase III Study Comparing the Bowel Cleansing Efficacy, Safety and Tolerability of NER1006 Versus Trisulfate Solution Using 2-Day Split-Dosing Regimen in Adults

Norgine

NCT02254486

COMPLETED NA 261 participants

Comprehensive Electronic Cancer Support System for the Treatment of Cancer Related Symptoms

University of Pittsburgh

NCT01640522

COMPLETED Phase 1 150 participants

A Study of XmAb®20717 in Subjects With Selected Advanced Solid Tumors

Xencor

NCT03517488

COMPLETED Phase 1 111 participants

A Safety, Pharmacokinetic and Efficacy Study of NUC-3373 in Combination With Standard Agents Used in Colorectal Cancer Treatment

NuCana

NCT03428958

COMPLETED Phase 1 95 participants

Phase 1 Study of MGD007 in Relapsed/Refractory Metastatic Colorectal Carcinoma

MacroGenics

NCT02248805

COMPLETED Phase 2 87 participants

Macrogol 3350-based Oral Osmotic Laxative in Preventing Cancer in Patients at Risk of Colorectal Cancer

National Cancer Institute (NCI)

NCT00828984

COMPLETED Phase 1 52 participants

Recombinant Vaccinia Virus Administered Intravenously in Patients With Metastatic, Refractory Colorectal Carcinoma

Jennerex Biotherapeutics

NCT01394939

COMPLETED Phase 2 40 participants

Evaluation of Surgically Resected Colorectal Adenomas and Carcinomas After 7 Days Pretreatment With Celecoxib

University of Alabama at Birmingham

NCT00582660

COMPLETED 24 participants

Psychological, Psychophysical and Epigenetic Determinants of Chronic Pain After Cytoreductive - Hyperthermic Intraoperative Chemotherapy

M.D. Anderson Cancer Center

NCT05083338

Phase Distribution

PhaseTrial count
Early Phase 1 19
Phase 2 9
Phase 3 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Colorectal Carcinoma Trial Landscape

ClinicalTrials.gov lists 54 US studies indexed under Colorectal Carcinoma, and 28 of those are currently open to recruitment — roughly 52% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Colorectal Carcinoma shows 1 late-stage studies (Phase 3 and Phase 4 combined) alongside 28 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Colorectal Carcinoma is led by National Cancer Institute (NCI) with 8 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 54 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Colorectal Carcinoma?

PlainTrial tracks 54 US clinical trials for Colorectal Carcinoma, of which 28 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Colorectal Carcinoma?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

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