Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Colorectal Carcinoma
Open-data reference.
54 US clinical trials · 28 currently recruiting
Active & Recent Trials
The Vanguard Study: Testing a New Way to Screen for Cancer
National Cancer Institute (NCI)
NCT06995898
Implementation of a ColoRectal Cancer Screening Tool in US Primary Care Practices - Usual Quality Improvement (10 Clinics) vs Normalization Process Theory-Participatory Learning in Action (10 Clinics)
University of Kansas Medical Center
NCT06682650
The Ohio State University (OSU) SCREEN Community Program
Ohio State University Comprehensive Cancer Center
NCT06666192
Assessing Benefits and Harms of Cannabis/Cannabinoid Use Among Cancer Patients Treated in Community Oncology Clinics
Wake Forest University Health Sciences
NCT06418204
Improving Colonoscopy Surveillance for Patients With High Risk Colon Polyps
Jonsson Comprehensive Cancer Center
NCT06376565
A Clinic-wide Intervention (Primary Care-GI Connect) for Improving Rates of Colonoscopy After Abnormal Fecal Immunochemical Test Result in Patients at Federally Qualified Health Centers
Jonsson Comprehensive Cancer Center
NCT06568016
Collection of Information to Better Understand Young Onset Colorectal Cancer
Memorial Sloan Kettering Cancer Center
NCT04489238
Collecting Blood and Stool Samples to Detect Colorectal Cancer or Advanced Neoplasia in Lynch Syndrome Patients
Mayo Clinic
NCT05410977
Confronting Cancer as a Community
University of Southern California
NCT06063928
Addressing Disparities in Colorectal Cancer Screening in Black and Underserved Phoenix Communities
Mayo Clinic
NCT05447923
Study of CP-383 in Patients With Advanced or Metastatic Solid Tumors
Tasca Therapeutics
NCT07030257
Tegavivint for the Treatment of Recurrent or Refractory Solid Tumors, Including Lymphomas and Desmoid Tumors
Children's Oncology Group
NCT04851119
CoGENES Randomized Controlled Trial (RCT)
University of Southern California
NCT07229443
A Study to Test Different Doses of BI 765049 in People With Advanced Cancer of the Colon, Rectum, Stomach, or Pancreas
Boehringer Ingelheim
NCT06882746
Study of JANX008 in Subjects With Advanced or Metastatic Solid Tumor Malignancies
Janux Therapeutics
NCT05783622
A Study of MGC028 in Participants With Advanced Solid Tumors
MacroGenics
NCT06723236
Changes in Reproductive and Sexual Health in People With Early Onset Colorectal Cancer
Memorial Sloan Kettering Cancer Center
NCT04812912
Phase 1 Study to Investigate TCRTs KRAS Mutation in Unresectable, Advanced, and/or Metastatic Solid Tumors
AstraZeneca
NCT06218914
Culturally Adapting an Intervention to Increase Genetic Testing in African American Cancer Survivors
Barbara Ann Karmanos Cancer Institute
NCT07436078
A Self-Monitoring Platform for Tracking Medication Safety and Concerns in Cancer Patients
University of Michigan Rogel Cancer Center
NCT07291414
A Web-Based Dyadic Intervention for Colorectal Cancer
Emory University
NCT05663203
A Study of NT-175 in Adult Subjects With Unresectable, Advanced, and/or Metastatic Solid Tumors That Are Positive for HLA-A*02:01 and the TP53 R175H Mutation
AstraZeneca
NCT05877599
Testing for Safety and Colorectal Cancer Preventive Effects of ONC201
National Cancer Institute (NCI)
NCT05630794
Determining the Biodistribution of an Imaging Tracer (68Ga-FAPi-46) in Patients With Solid Tumors or Hematologic Cancers
Jonsson Comprehensive Cancer Center
NCT07118176
Role of Diet on the Microbiome of the Digestive System
M.D. Anderson Cancer Center
NCT04666727
Evaluating the Effects of an Exercise Intervention on the Gut Microbiota in Stage II-III Colorectal Cancer Survivors
Fred Hutchinson Cancer Center
NCT05930496
The Cancer Connected Access and Remote Expertise Beyond Walls Program to Provide In-Home Cancer Treatment and Improve Treatment Satisfaction in Cancer Patients Living in the Florida Panhandle and Surrounding Areas
Mayo Clinic
NCT07285044
Immune Response Activation for the Treatment of Unresectable Metastatic Colorectal Cancer or CEA Positive Metastatic Breast Cancer
City of Hope Medical Center
NCT06130826
Implementation Research to Increase Colorectal Cancer Screening Rates Among Low Income and Ethnic Minority Groups
Jonsson Comprehensive Cancer Center
NCT06090643
Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors, Lymphomas, or Multiple Myeloma (The MATCH Screening Trial)
National Cancer Institute (NCI)
NCT02465060
Young-Onset Colorectal Cancer
M.D. Anderson Cancer Center
NCT02863107
HOPE-Genomics Intervention for the Improvement of Cancer Patient Knowledge of Genomics
City of Hope Medical Center
NCT04905082
Survivorship Care Plans and Telehealth Education for the Improvement of Access to Cancer Survivorship, the IMPACT Study
Fred Hutchinson Cancer Center
NCT04081779
Testing a Combination of Vaccines for Cancer Prevention in Lynch Syndrome
National Cancer Institute (NCI)
NCT05419011
Lesion Detection Assessment in the Liver: Standard vs Low Radiation Dose Using Varied Post-Processing Techniques
M.D. Anderson Cancer Center
NCT03151564
Study of NGM831 as Monotherapy and in Combination With Pembrolizumab or Pembrolizumab and NGM438 in Advanced or Metastatic Solid Tumors
NGM Biopharmaceuticals
NCT05215574
Vaccine Therapy in Treating Patients With Newly Diagnosed Advanced Colon Polyps
National Cancer Institute (NCI)
NCT02134925
Aspirin in Preventing Colorectal Cancer in Patients With Colorectal Adenoma
National Cancer Institute (NCI)
NCT02965703
Platform Study of JDQ443 in Combinations in Patients With Advanced Solid Tumors Harboring the KRAS G12C Mutation
Novartis Pharmaceuticals
NCT05358249
Cancer Preventive Vaccine Nous-209 for Lynch Syndrome Patients
National Cancer Institute (NCI)
NCT05078866
Testing Atorvastatin to Lower Colon Cancer Risk in Longstanding Ulcerative Colitis
Northwestern University
NCT04767984
Tucatinib Plus Trastuzumab and Oxaliplatin-based Chemotherapy or Pembrolizumab-containing Combinations for HER2+ Gastrointestinal Cancers
Seagen, a wholly owned subsidiary of Pfizer
NCT04430738
First-in-Human Positron Emission Tomography Study Using the 18F-αvβ6-Binding-Peptide
Julie L. Sutcliffe, Ph.D
NCT03164486
Community Genetic Navigation Engagement Specialists to Increase Knowledge About Colorectal Cancer Genetics in Hispanic/Latino/a Communities
University of Southern California
NCT07276048
Study of Cabozantinib Plus TAS102 in mCRC as Salvage Therapy
University of California, Irvine
NCT04868773
Multicenter Randomized Parallel Group Phase III Study Comparing the Bowel Cleansing Efficacy, Safety and Tolerability of NER1006 Versus Trisulfate Solution Using 2-Day Split-Dosing Regimen in Adults
Norgine
NCT02254486
Comprehensive Electronic Cancer Support System for the Treatment of Cancer Related Symptoms
University of Pittsburgh
NCT01640522
A Study of XmAb®20717 in Subjects With Selected Advanced Solid Tumors
Xencor
NCT03517488
A Safety, Pharmacokinetic and Efficacy Study of NUC-3373 in Combination With Standard Agents Used in Colorectal Cancer Treatment
NuCana
NCT03428958
Phase 1 Study of MGD007 in Relapsed/Refractory Metastatic Colorectal Carcinoma
MacroGenics
NCT02248805
Macrogol 3350-based Oral Osmotic Laxative in Preventing Cancer in Patients at Risk of Colorectal Cancer
National Cancer Institute (NCI)
NCT00828984
Recombinant Vaccinia Virus Administered Intravenously in Patients With Metastatic, Refractory Colorectal Carcinoma
Jennerex Biotherapeutics
NCT01394939
Evaluation of Surgically Resected Colorectal Adenomas and Carcinomas After 7 Days Pretreatment With Celecoxib
University of Alabama at Birmingham
NCT00582660
Psychological, Psychophysical and Epigenetic Determinants of Chronic Pain After Cytoreductive - Hyperthermic Intraoperative Chemotherapy
M.D. Anderson Cancer Center
NCT05083338
Phase Distribution
| Phase | Trial count |
|---|---|
| Early Phase 1 | 19 |
| Phase 2 | 9 |
| Phase 3 | 1 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Colorectal Carcinoma Trial Landscape
ClinicalTrials.gov lists 54 US studies indexed under Colorectal Carcinoma, and 28 of those are currently open to recruitment — roughly 52% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Colorectal Carcinoma shows 1 late-stage studies (Phase 3 and Phase 4 combined) alongside 28 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Colorectal Carcinoma is led by National Cancer Institute (NCI) with 8 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 54 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Colorectal Carcinoma?
PlainTrial tracks 54 US clinical trials for Colorectal Carcinoma, of which 28 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Colorectal Carcinoma?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.