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NCT07040449 · ClinicalTrials.gov registry record · NA
Stress Trajectories and Anhedonia in Adolescence Research Study
A NA study of Anhedonia and Adolescent Development, sponsored by University of North Carolina, Chapel Hill.
- Recruiting
- Registry status
- NA
- Development phase
- 192
- Enrollment target
- 1
- Study location
NCT07040449: Recruiting NA study of Anhedonia and Adolescent Development, sponsored by University of North Carolina, Chapel Hill.
NCT07040449 is a NA study of Anhedonia and Adolescent Development that is actively recruiting participants, run by University of North Carolina, Chapel Hill. The registered enrollment target is 192 participants, above the 101-participant average among 21 other Anhedonia trials with a reported enrollment target (90% higher). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT07040449, a NA study of Anhedonia and Adolescent Development, is actively recruiting participants, sponsored by University of North Carolina, Chapel Hill.
- RECRUITING
- Registry status
- NA
- Development phase
- 192 participants
- Enrollment target
- 1
- Study location
Study Summary
This project will examine how multiple biological measures from the brain and the body's stress response system contribute to anhedonia (the loss of pleasure) in adolescence. The goal of this project is to see if it is possible to combine these biological measures to describe different patterns of activity in the brain and body that adolescents may have in response to stress. The main question this study aims to answer is whether different patterns of activity in the brain and body are related to whether adolescents develop anhedonia and how high or low levels of anhedonia are over time. This study will enroll 192 adolescents who are between 13 and 15 years. Adolescents will complete tasks three times: at the beginning of the study, 10 months after that, and then 10 months after that. In total, they will be part of the study for 20 months. At each time, adolescents will complete surveys, provide samples of spit to measure hormones and provide pictures of their brain to measure brain activity, participate in mildly stressful tasks, and complete different activities that measure how they think. The investigators will also ask each adolescent's parent or legal guardian to answer some surveys about themselves and their child.
Primary Outcome
The Snaith-Hamilton Pleasure Scale (SHAPS) is a measure used to assess anhedonia. It contains 14-items scored on a 4-point Likert scale ranging from "strongly disagree" (1) to "strongly agree" (4). The sum of these responses is taken to find the total score, which ranges from 0-56 with lower scores indicating higher overall anhedonia.
Conditions Studied
Interventions
- BEHAVIORAL Montreal Imaging Stress Task
- BEHAVIORAL Trier Social Stress Test for Children
Study Locations (1)
North Carolina
- University of North Carolina at Chapel Hill - Chapel Hill
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 192 participants |
| Start Date | 2025-03-12 |
| Est. Completion | 2030-02 |
| Phase | NA |
What NCT07040449 shows while recruiting
NCT07040449 is an interventional study that assigns participants to a tested intervention. The registered 192 participants enrollment target is mid-sized for trials with a published cap, above the 101-participant average among 21 other Anhedonia trials with a reported enrollment target (90% higher).
The record links to 3 conditions, with Anhedonia appearing as the primary indexed condition, and to 2 interventions - of which Montreal Imaging Stress Task is the first listed.
NCT07040449 reports a single indexed study location in North Carolina.
Frequently Asked Questions
What is clinical trial NCT07040449 about?
NCT07040449 is a clinical study titled "Stress Trajectories and Anhedonia in Adolescence Research Study". This project will examine how multiple biological measures from the brain and the body's stress response system contribute to anhedonia (the loss of pleasure) in adolescence. The goal of this project is to see if it is possible to combine these biological measures to describe different patterns of a...
What is the current status of trial NCT07040449?
This trial is currently recruiting. It is a NA study. The enrollment target is 192 participants. The study started on 2025-03-12. Estimated completion is 2030-02.
What conditions does trial NCT07040449 study?
This clinical trial studies the following conditions: Anhedonia, Adolescent Development, Stress Response.
What interventions are being tested in trial NCT07040449?
The interventions under investigation include: Montreal Imaging Stress Task (BEHAVIORAL), Trier Social Stress Test for Children (BEHAVIORAL).
Who is sponsoring clinical trial NCT07040449?
This trial is sponsored by University of North Carolina, Chapel Hill, which has 1,109 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT07040449 being conducted?
This trial has 1 study location across North Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT07040449's enrollment target sits among peer trials
192 2nd of 21 the highest of 21 other Anhedonia trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Anhedonia trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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