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NCT06230757 · ClinicalTrials.gov registry record · Phase 2
Psilocybin for Treatment-Resistant Depression
A Phase 2 study of Major Depressive Disorder and Treatment-Resistant Depression, sponsored by University of Colorado, Denver.
- Active
- Registry status
- Phase 2
- Development phase
- 40
- Enrollment target
- 1
- Study location
NCT06230757: Active Phase 2 study of Major Depressive Disorder and Treatment-Resistant Depression, sponsored by University of Colorado, Denver.
NCT06230757 is a Phase 2 study of Major Depressive Disorder and Treatment-Resistant Depression that is active but no longer recruiting, run by University of Colorado, Denver. The registered enrollment target is 40 participants, below the 377-participant average among 282 other Major Depressive Disorder trials with a reported enrollment target (89% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06230757, a Phase 2 study of Major Depressive Disorder and Treatment-Resistant Depression, is active but no longer recruiting, sponsored by University of Colorado, Denver.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 2
- Development phase
- 40 participants
- Enrollment target
- 1
- Study location
Study Summary
The purpose of this study is to evaluate the efficacy of psilocybin on the symptom of anhedonia in individuals with treatment-resistant major depressive disorder.
Primary Outcome
The DARS is a 17-item scale that captures multiple domains of anhedonia found in depression. Scores range from 0 to 68 with lower scores indicating greater anhedonia and 68 indicating no anhedonia.
Conditions Studied
Interventions
- DRUG Psilocybin 25mg
- DRUG Placebo (active placebo)
Study Locations (1)
Colorado
- University of Colorado Anschutz Medical Campus - Aurora
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 40 participants |
| Start Date | 2024-07-08 |
| Est. Completion | 2026-03-01 |
| Phase | Phase 2 |
What the registry record for NCT06230757 still lists
NCT06230757 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 40 participants, a relatively small participant target, below the 377-participant average among 282 other Major Depressive Disorder trials with a reported enrollment target (89% lower).
The record links to 3 conditions, with Major Depressive Disorder appearing as the primary indexed condition, and to 2 interventions - of which Psilocybin 25mg is the first listed.
NCT06230757 reports a single indexed study location in Colorado.
Frequently Asked Questions
What is clinical trial NCT06230757 about?
NCT06230757 is a clinical study titled "Psilocybin for Treatment-Resistant Depression". The purpose of this study is to evaluate the efficacy of psilocybin on the symptom of anhedonia in individuals with treatment-resistant major depressive disorder.
What is the current status of trial NCT06230757?
This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 40 participants. The study started on 2024-07-08. Estimated completion is 2026-03-01.
What conditions does trial NCT06230757 study?
This clinical trial studies the following conditions: Major Depressive Disorder, Treatment-Resistant Depression, Anhedonia.
What interventions are being tested in trial NCT06230757?
The interventions under investigation include: Psilocybin 25mg (DRUG), Placebo (active placebo) (DRUG).
Who is sponsoring clinical trial NCT06230757?
This trial is sponsored by University of Colorado, Denver, which has 1,283 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06230757 being conducted?
This trial has 1 study location across Colorado. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Major Depressive Disorder
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06230757's enrollment target sits among peer trials
40 196th of 282 higher than 76 of 282 other Major Depressive Disorder trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Major Depressive Disorder trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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