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ClinicalTrials.gov 4 recruiting now official registry

Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome clinical trials

4 of 22 indexed Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome trials are currently recruiting.

22 US clinical trials · 4 currently recruiting

Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome is the subject of 22 registered US clinical trials on ClinicalTrials.gov, 4 of them currently open to new participants. 0 are in Phase 3-4 (later-stage) and 22 in Phase 1-2 (earlier-stage). The most active sponsor is National Cancer Institute (NCI), running 8 of these trials.

The research picture

Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome has 22 registered US clinical trials, 4 of them open to new participants right now, about 18% of the total.

4
recruiting participants now
18%
of trials open to enrollment
0
in Phase 3–4 (later-stage)
8
top sponsor: National Cancer Institute (NCI)
Phase 110Phase 212

Active & Recent Trials

22 total, page 1 of 1

RECRUITING Phase 1 75 participants

211^At-BC8-B10 Before Donor Stem Cell Transplant in Treating Patients With High-Risk Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Myelodysplastic Syndrome, or Mixed-Phenotype Acute Leukemia

Fred Hutchinson Cancer Center

NCT03128034

RECRUITING Phase 1 58 participants

Edetate Calcium Disodium or Succimer in Treating Patients With Acute Myeloid Leukemia or Myelodysplastic Syndrome Undergoing Chemotherapy

M.D. Anderson Cancer Center

NCT03630991

RECRUITING Phase 1 51 participants

Ruxolitinib in Combination With Venetoclax With and Without Azacitidine in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia

Jennifer Saultz

NCT03874052

RECRUITING Phase 1 30 participants

211At-BC8-B10 Followed by Donor Stem Cell Transplant in Treating Patients With Relapsed or Refractory High-Risk Acute Leukemia or Myelodysplastic Syndrome

Fred Hutchinson Cancer Center

NCT03670966

ACTIVE NOT RECRUITING Phase 1 135 participants

Vorinostat and Azacitidine in Treating Patients With Myelodysplastic Syndromes or Acute Myeloid Leukemia

National Cancer Institute (NCI)

NCT00392353

ACTIVE NOT RECRUITING Phase 1 72 participants

Hu8F4 in Treating Patients With Advanced Hematologic Malignancies

M.D. Anderson Cancer Center

NCT02530034

ACTIVE NOT RECRUITING Phase 2 72 participants

Clofarabine and Melphalan Before Donor Stem Cell Transplant in Treating Patients With Myelodysplasia, Acute Leukemia in Remission, or Chronic Myelomonocytic Leukemia

City of Hope Medical Center

NCT01885689

ACTIVE NOT RECRUITING Phase 2 60 participants

BLAST MRD AML-2: BLockade of PD-1 Added to Standard Therapy to Target Measurable Residual Disease in Acute Myeloid Leukemia 2- A Randomized Phase 2 Study of Anti-PD-1 Pembrolizumab in Combination With Azacitidine and Venetoclax as Frontline Therapy in Unfit Patients With Acute Myeloid Leukemia

National Cancer Institute (NCI)

NCT04284787

ACTIVE NOT RECRUITING Phase 1 53 participants

Pevonedistat, Cytarabine, and Idarubicin in Treating Patients With Acute Myeloid Leukemia

University of Southern California

NCT03330821

ACTIVE NOT RECRUITING Phase 2 50 participants

Liposome-encapsulated Daunorubicin-Cytarabine and Gemtuzumab Ozogamicin in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia (AML) or High Risk Myelodysplastic Syndrome

M.D. Anderson Cancer Center

NCT03672539

ACTIVE NOT RECRUITING Phase 2 49 participants

BLAST MRD AML-1: BLockade of PD-1 Added to Standard Therapy to Target Measurable Residual Disease in Acute Myeloid Leukemia 1- A Randomized Phase 2 Study of Anti-PD-1 Pembrolizumab in Combination With Intensive Chemotherapy as Frontline Therapy in Patients With Acute Myeloid Leukemia

National Cancer Institute (NCI)

NCT04214249

ACTIVE NOT RECRUITING Phase 2 48 participants

Cognitive Behavioral Therapy in Helping Patients With Acute Myeloid Leukemia or Lymphoma With Cancer-Related Fatigue

M.D. Anderson Cancer Center

NCT03747757

ACTIVE NOT RECRUITING Phase 2 25 participants

Topotecan Hydrochloride and Carboplatin With or Without Veliparib in Treating Advanced Myeloproliferative Disorders and Acute Myeloid Leukemia or Chronic Myelomonocytic Leukemia

National Cancer Institute (NCI)

NCT03289910

ACTIVE NOT RECRUITING Phase 1 24 participants

Testing the Addition of an Anti-cancer Drug, Navtemadlin, to the Usual Treatments (Cytarabine and Idarubicin) in Patients With Acute Myeloid Leukemia

National Cancer Institute (NCI)

NCT04190550

ACTIVE NOT RECRUITING Phase 2 21 participants

CPX-351 for the Treatment of Secondary Acute Myeloid Leukemia in Patients Younger Than 60 Years Old

Roswell Park Cancer Institute

NCT04269213

ACTIVE NOT RECRUITING Phase 2 14 participants

Using the Anticancer Drug Olaparib to Treat Relapsed/Refractory Acute Myeloid Leukemia or Myelodysplastic Syndrome With an Isocitrate Dehydrogenase (IDH) Mutation

National Cancer Institute (NCI)

NCT03953898

COMPLETED Phase 2 165 participants

Decitabine With or Without Bortezomib in Treating Older Patients With Acute Myeloid Leukemia

National Cancer Institute (NCI)

NCT01420926

COMPLETED Phase 2 150 participants

Nivolumab and Azacitidine With or Without Ipilimumab in Treating Patients With Refractory/Relapsed or Newly Diagnosed Acute Myeloid Leukemia

M.D. Anderson Cancer Center

NCT02397720

COMPLETED Phase 2 61 participants

Combination Chemotherapy and Dasatinib in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia

National Cancer Institute (NCI)

NCT01238211

COMPLETED Phase 2 56 participants

CPX-351 in Treating Patients With Newly Diagnosed, High-Risk Acute Myeloid Leukemia

M.D. Anderson Cancer Center

NCT02286726

COMPLETED Phase 1 54 participants

Natural Killer Cells Before and After Donor Stem Cell Transplant in Treating Patients With Acute Myeloid Leukemia, Myelodysplastic Syndrome, or Chronic Myelogenous Leukemia

M.D. Anderson Cancer Center

NCT01904136

COMPLETED Phase 1 20 participants

8-Chloroadenosine in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia

City of Hope Medical Center

NCT02509546

Phase Distribution

PhaseTrial count
Phase 1 10
Phase 2 12

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome Trial Landscape

22 indexed Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome studies · 4 recruiting (18%).

Phase mix: 0 late (III/IV) vs 22 early (I/II).

Top sponsor: National Cancer Institute (NCI) (8 trials), 6 others listed. 22 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome?

PlainTrial tracks 22 US clinical trials for Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome, of which 4 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Acute Myeloid Leukemia Arising From Previous Myelodysplastic Syndrome?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.