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NCT05240352 · ClinicalTrials.gov registry record · NA
Developing Brain Imaging Analysis Expertise for Personalizing Transcranial Electric Stimulation in Anhedonia Treatment of Patients With Bipolar Depression
A NA study of Anhedonia, sponsored by The University of Texas Health Science Center, Houston.
- Recruiting
- Registry status
- NA
- Development phase
- 45
- Enrollment target
- 1
- Study location
NCT05240352: Recruiting NA study of Anhedonia, sponsored by The University of Texas Health Science Center, Houston.
NCT05240352 is a NA study of Anhedonia that is actively recruiting participants, run by The University of Texas Health Science Center, Houston. The registered enrollment target is 45 participants, below the 108-participant average among 21 other Anhedonia trials with a reported enrollment target (58% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05240352, a NA study of Anhedonia, is actively recruiting participants, sponsored by The University of Texas Health Science Center, Houston.
- RECRUITING
- Registry status
- NA
- Development phase
- 45 participants
- Enrollment target
- 1
- Study location
Study Summary
The purpose of this study is to investigate whether transcranial direct-current stimulation (tDCS) will engage reward-related brain circuitry, more specifically the uncinate fasciculus (UF) tract, which connects the orbitofrontal cortex (OFC) and nucleus accumbens (NAcc) regions. Also to evaluate whether the changes in the fractional anisotropy (FA) of the UF tract are associated with changes of clinical symptoms of anhedonia and finally to investigate the moderation role of simulated electric fields (EFs) in an association between FA of the UF and symptoms of anhedonia.
Primary Outcome
Change in the fractional anisotropy of the uncinate fasciculus as assessed by diffusion tensor imaging (DTI)
Conditions Studied
Interventions
- DEVICE sham tDCS
- DEVICE active tDCS
Study Locations (1)
Texas
- The University of Texas Health Science Center at Houston - Houston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 45 participants |
| Start Date | 2022-10-06 |
| Est. Completion | 2026-12-01 |
| Phase | NA |
What NCT05240352 shows while recruiting
NCT05240352 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 45 participants, a relatively small participant target, below the 108-participant average among 21 other Anhedonia trials with a reported enrollment target (58% lower).
The record links to 1 condition, with Anhedonia appearing as the primary indexed condition, and to 2 interventions - of which sham tDCS is the first listed.
NCT05240352 reports a single indexed study location in Texas.
Frequently Asked Questions
What is clinical trial NCT05240352 about?
NCT05240352 is a clinical study titled "Developing Brain Imaging Analysis Expertise for Personalizing Transcranial Electric Stimulation in Anhedonia Treatment of Patients With Bipolar Depression". The purpose of this study is to investigate whether transcranial direct-current stimulation (tDCS) will engage reward-related brain circuitry, more specifically the uncinate fasciculus (UF) tract, which connects the orbitofrontal cortex (OFC) and nucleus accumbens (NAcc) regions. Also to evaluate wh...
What is the current status of trial NCT05240352?
This trial is currently recruiting. It is a NA study. The enrollment target is 45 participants. The study started on 2022-10-06. Estimated completion is 2026-12-01.
What conditions does trial NCT05240352 study?
This clinical trial studies the following conditions: Anhedonia.
What interventions are being tested in trial NCT05240352?
The interventions under investigation include: sham tDCS (DEVICE), active tDCS (DEVICE).
Who is sponsoring clinical trial NCT05240352?
This trial is sponsored by The University of Texas Health Science Center, Houston, which has 732 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05240352 being conducted?
This trial has 1 study location across Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Anhedonia
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT05240352's enrollment target sits among peer trials
45 20th of 21 higher than 2 of 21 other Anhedonia trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Anhedonia trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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