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NCT06132581 · ClinicalTrials.gov registry record · NA
Causal Role of Delta-beta Coupling for Goal-directed Behavior in Anhedonic Depression
A NA study of Major Depressive Disorder and Anhedonia, sponsored by Florida State University.
- Recruiting
- Registry status
- NA
- Development phase
- 72
- Enrollment target
- 1
- Study location
NCT06132581: Recruiting NA study of Major Depressive Disorder and Anhedonia, sponsored by Florida State University.
NCT06132581 is a NA study of Major Depressive Disorder and Anhedonia that is actively recruiting participants, run by Florida State University. The registered enrollment target is 72 participants, below the 377-participant average among 282 other Major Depressive Disorder trials with a reported enrollment target (81% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06132581, a NA study of Major Depressive Disorder and Anhedonia, is actively recruiting participants, sponsored by Florida State University.
- RECRUITING
- Registry status
- NA
- Development phase
- 72 participants
- Enrollment target
- 1
- Study location
Study Summary
Anhedonia, the inability to seek-out and experience pleasure, is a common symptom in depression that predicts treatment-resistance and is sometimes exacerbated by first-line antidepressants. In our previous research, we found that anhedonia decreases goal-directed behavior and its related neural activity. In this study, we will investigate target engagement from five-consecutive days of stimulation for participants that are within a unipolar major depressive episode and also have high symptoms of anhedonia.
Primary Outcome
Phase-amplitude coupling strength is calculated between the phase of low-frequency activity in prefrontal electrodes and amplitude of high-frequency in posterior cortex. These signals are extracted from the S-EEfRT during the decision period. Instantaneous phase and amplitude will be calculated by averaging electrodes in the regions, band-filtering to the specified range, and performing the Hilbert transform. Next, a hybrid signal is created using the high-frequency amplitude and low-frequency p
Conditions Studied
Interventions
- DEVICE Delta-beta tACS via the Neurocare Direct Current Stimulator Multi-Channel 4
- DEVICE Theta-gamma tACS via the Neurocare Direct Current Stimulator Multi-Channel 4
- DEVICE Sham tACS via the Neurocare Direct Current Stimulator Multi-Channel 4
Study Locations (1)
Florida
- Florida State University - Tallahassee
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 72 participants |
| Start Date | 2024-01-24 |
| Est. Completion | 2026-07-31 |
| Phase | NA |
What NCT06132581 shows while recruiting
NCT06132581 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 72 participants, a relatively small participant target, below the 377-participant average among 282 other Major Depressive Disorder trials with a reported enrollment target (81% lower).
The record links to 2 conditions, with Major Depressive Disorder appearing as the primary indexed condition, and to 3 interventions - of which Delta-beta tACS via the Neurocare Direct Current Stimulator Multi-Channel 4 is the first listed.
NCT06132581 reports a single indexed study location in Florida.
Frequently Asked Questions
What is clinical trial NCT06132581 about?
NCT06132581 is a clinical study titled "Causal Role of Delta-beta Coupling for Goal-directed Behavior in Anhedonic Depression". Anhedonia, the inability to seek-out and experience pleasure, is a common symptom in depression that predicts treatment-resistance and is sometimes exacerbated by first-line antidepressants. In our previous research, we found that anhedonia decreases goal-directed behavior and its related neural act...
What is the current status of trial NCT06132581?
This trial is currently recruiting. It is a NA study. The enrollment target is 72 participants. The study started on 2024-01-24. Estimated completion is 2026-07-31.
What conditions does trial NCT06132581 study?
This clinical trial studies the following conditions: Major Depressive Disorder, Anhedonia.
What interventions are being tested in trial NCT06132581?
The interventions under investigation include: Delta-beta tACS via the Neurocare Direct Current Stimulator Multi-Channel 4 (DEVICE), Theta-gamma tACS via the Neurocare Direct Current Stimulator Multi-Channel 4 (DEVICE), Sham tACS via the Neurocare Direct Current Stimulator Multi-Channel 4 (DEVICE).
Who is sponsoring clinical trial NCT06132581?
This trial is sponsored by Florida State University, which has 219 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06132581 being conducted?
This trial has 1 study location across Florida. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Major Depressive Disorder
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06132581's enrollment target sits among peer trials
72 153rd of 282 higher than 129 of 282 other Major Depressive Disorder trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Major Depressive Disorder trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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