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Amputation: early-phase trial registry
38 of 66 indexed Amputation trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #211 of 28,707 conditions by registered trial count.
66 US clinical trials · 38 currently recruiting · #211 of 28,707 conditions by registered trial count
Amputation: 66 US clinical trials tracked, 38 recruiting.
Amputation is the subject of 66 registered US clinical trials on ClinicalTrials.gov, 38 of them currently open to new participants. 1 are in Phase 3-4 (later-stage) and 6 in Phase 1-2 (earlier-stage). The most active sponsor is Shirley Ryan AbilityLab, running 7 of these trials.
Enrollment posture brief
Registry condition amputation
OPEN 38 | RECR 58% | LATE 1 | EARLY 6 | RANK #211 | SPON 7
Volume-matched condition peers
Nearest open-share peer: Overweight or Obesity (58% recruiting · 33 trials)
Amputation lists 38 open slots (58% of 66 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Amputation on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Amputation is recruiting above its size-band peers.
38 of 66 indexed trials (57.6%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Amputation trials is spread across many organizations.
Shirley Ryan AbilityLab accounts for 7 of 66 trials (10.6%). 35 distinct sponsors appear on at least one study for this condition label.
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Most Amputation trials plan to enrol fewer than 100 people.
Median target enrolment is 20 among the 66 trials that report a genuine target (sentinel values excluded). 55 of those (83.3%) plan for fewer than 100 participants.
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Amputation research is mostly interventional.
59 interventional and 7 observational studies make up this index (89.4% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
66 total, page 1 of 2
Pro APP Prosthetic Outcome Registry
Össur Iceland ehf
NCT06210620
Cryo NerVe Block Extremity AmputatioN RegIStry for Post Operative and pHantom Limb Pain
AtriCure
NCT06908538
PO vs IV Antibiotics for the Treatment of Infected Nonunion of Fractures After Fixation
Major Extremity Trauma Research Consortium
NCT05699174
Evaluating the Experience of Upper Limb Prosthesis Use
Louis Stokes VA Medical Center
NCT04855214
Hand Transplantation
NYU Langone Health
NCT02476838
Effects of Microprocessor-controlled Prosthetic Knees on Fall-related Health Outcomes in Limited Community Ambulators
Hanger Institute for Clinical Research and Education
NCT06937242
A Prosthetic Foot Test-Drive Strategy for Improving Stability in Veterans With Leg Amputations
Seattle Institute for Biomedical and Clinical Research
NCT05473065
Effectiveness of Frontal Plane Adaptability in a Novel Foot Prosthesis
University of Washington
NCT06214026
Influence of Prosthetic Foot Stiffness on Transtibial Osseointegrated Bone-Anchored Limb Outcomes
University of Colorado, Denver
NCT07263945
Human Penile Allotransplantation
Johns Hopkins University
NCT02395497
Autologous Volar Fibroblast Injection Into the Stump Site of Amputees
Johns Hopkins University
NCT03947450
Assessing Ambulatory and Non-ambulatory Community Mobility in People With Lower Limb Amputation
Virginia Commonwealth University
NCT07387744
Target Muscle Re-innervation and Regenerative Peripheral Nerve Interfaces Alone and in Combination for the Treatment of Residual and Phantom Limb Pain in Cancer Patients Who Have Received an Amputation
M.D. Anderson Cancer Center
NCT06840262
Efficacy and Mechanisms of Virtual Reality Treatment of Phantom Leg Pain.Home-Based Treatment
Albert Einstein Healthcare Network
NCT07044323
Controlling Locomotion Over Continuously Varying Activities for Agile Powered Prosthetic Legs
University of Michigan
NCT06138977
Deploying Digital Prosthetic Interface Technology and Exercise in Dysvascular Amputees
Spaulding Rehabilitation Hospital
NCT05656924
Prosthetic Performance Enhancement Trial
University of Nevada, Las Vegas
NCT06419920
Comparing the Attentional Demands and Functional Outcomes in People With Transradial Amputation
Virginia Commonwealth University
NCT07075042
Effects of Myoelectric Channel Count and Targeting for Upper Limb Prosthetic Control
Liberating Technologies
NCT07011420
Clinical Outcomes With Non-Powered vs. Powered Prosthetic Knees by K2-level Amputees
Liberating Technologies
NCT06194838
AMI Construction in Lower Extremity Residual Limbs
Brigham and Women's Hospital
NCT04063592
Intuitive Control of a Hybrid Prosthetic Leg During Ambulation
Shirley Ryan AbilityLab
NCT04038151
Hybrid Pump Technology
VA Office of Research and Development
NCT04230512
Multicenter Trial Evaluating the Safety and Efficacy of Autologous Volar Fibroblast Injection Into the Terminal Limb of Amputees.
Major Extremity Trauma Research Consortium
NCT04839497
A Novel Approach to Upper Extremity Amputation to Augment Volitional Control and Restore Proprioception
Brigham and Women's Hospital
NCT03882073
Enhancing Motor Function in Individuals with Lower Limb Amputation
University of Nevada, Las Vegas
NCT06638723
Understanding How Powered Componentry Impacts K2-Level Transfemoral Amputee Gait
Shirley Ryan AbilityLab
NCT06433648
Detecting Change in Muscle Parameters, Pain, and Function With NMES for TTA
Sara Peterson-Snyder
NCT06830876
Impact of Improving Footwear Options
VA Office of Research and Development
NCT05601869
Study of Efficacy of the MyoTrain System in a Population of Individuals With Trans-radial Limb Loss
Infinite Biomedical Technologies
NCT05888428
Feasibility of Neural Feedback for Lower Limb Amputees
Louis Stokes VA Medical Center
NCT03409133
Short-term Implanted Electrodes Following Regenerative Peripheral Nerve Surgery for Improving Prosthetic Limb Control Signals
University of Michigan
NCT03260400
A Unique Body-Powered Terminal Device With Enhanced Grasping Capabilities for Individuals With Upper Limb Loss
Little Room Innovations
NCT07254247
Regulatory Clearance of the Glide Control Strategy for Upper Limb Prostheses
Infinite Biomedical Technologies
NCT06539936
Powered Prosthesis for Use With TF Osseointegration Recipients
Shirley Ryan AbilityLab
NCT06160882
Evaluation of Myoelectric Implantable Recording Array (MIRA) in Participants With Transradial Amputation
Boninger, Michael, MD
NCT05768802
Can an Array of Micro-electrodes Implanted in a Human Nerve Record Neural Signals and Provide Feedback?
University of Utah
NCT05505513
Regenerative Peripheral Nerve Interface for Control of Lower Limb Prostheses
University of Michigan
NCT06275282
Optimizing Prosthetic Prescription to Mitigate the Effects of Perspiration
VA Puget Sound Health Care System
NCT07024342
Personalized Mobility Interventions Using Smart Sensor Resources for Lower-Limb Prosthesis Users
Shirley Ryan AbilityLab
NCT03930199
VR to Evaluate Phantom Limb Pain
Shirley Ryan AbilityLab
NCT05915065
GaMA Metric to Quantify Functional Importance of Various Upper Limb Prosthetic Devices
Shirley Ryan AbilityLab
NCT06420687
Transfemoral Osseointegrated Prosthesis Limb-Load Symmetry Training
University of Colorado, Denver
NCT05695911
Tolerability and Feasibility Pilot Clinical Study of a Large-Diameter Nerve Cap for Protecting and Preserving Terminated Nerve Ends
Axogen Corporation
NCT04865679
Magnetic Bead Tracking System and eOPRA Implant System With Bionic Prosthesis for Transtibial Amputees
Brigham and Women's Hospital
NCT06391697
Development and Usability of an Adjustable Prosthesis for Aquatic Therapy
Shirley Ryan AbilityLab
NCT06259695
A Client-Based Outcome System for Individuals With Lower Limb Amputation
University of Washington
NCT01750372
Self-Management Program for Persons With Limb Loss
Johns Hopkins Bloomberg School of Public Health
NCT00198692
Understanding Prosthetic Needs and Outcomes in Women Veterans With Amputation
VA Office of Research and Development
NCT03733054
Dual-tasking for Individuals With Lower Limb Amputation: Exploring the Relationship to Falls and Instrumental Activities of Daily Living
VA Office of Research and Development
NCT05119192
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 1 |
| Phase 2 | 5 |
| Phase 3 | 1 |
Top Sponsors
Named interventions
Most-linked intervention names on Amputation records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Amputation trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Amputation page
66 registered trials, 38 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 38 Amputation trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Shirley Ryan AbilityLab sponsors the most Amputation trials on record, review their full trial history before evaluating a specific study. See Shirley Ryan AbilityLab's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Amputation condition card totals 66 registered trials; most-linked intervention Attention Control; top US site state Illinois. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.