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Amputation clinical trials
Every US clinical trial registered for Amputation — phase mix, recruiting status, and the sponsors running them, straight from the NIH ClinicalTrials.gov registry.
66 US clinical trials · 38 currently recruiting
The research picture
Amputation has 66 registered US clinical trials, 38 of them open to new participants right now — about 58% of the total.
- 38
- recruiting participants now
- 58%
- of trials open to enrollment
- 1
- in Phase 3–4 (later-stage)
- 7
- top sponsor: Shirley Ryan AbilityLab
Counts reflect the public ClinicalTrials.gov registry as last mirrored by PlainTrial. Status and phase are reported by each study's sponsor. This is reference information, not medical advice.
Active & Recent Trials
Pro APP Prosthetic Outcome Registry
Össur Iceland ehf
NCT06210620
Cryo NerVe Block Extremity AmputatioN RegIStry for Post Operative and pHantom Limb Pain
AtriCure
NCT06908538
PO vs IV Antibiotics for the Treatment of Infected Nonunion of Fractures After Fixation
Major Extremity Trauma Research Consortium
NCT05699174
Evaluating the Experience of Upper Limb Prosthesis Use
Louis Stokes VA Medical Center
NCT04855214
Hand Transplantation
NYU Langone Health
NCT02476838
Effects of Microprocessor-controlled Prosthetic Knees on Fall-related Health Outcomes in Limited Community Ambulators
Hanger Institute for Clinical Research and Education
NCT06937242
A Prosthetic Foot Test-Drive Strategy for Improving Stability in Veterans With Leg Amputations
Seattle Institute for Biomedical and Clinical Research
NCT05473065
Effectiveness of Frontal Plane Adaptability in a Novel Foot Prosthesis
University of Washington
NCT06214026
Influence of Prosthetic Foot Stiffness on Transtibial Osseointegrated Bone-Anchored Limb Outcomes
University of Colorado, Denver
NCT07263945
Human Penile Allotransplantation
Johns Hopkins University
NCT02395497
Autologous Volar Fibroblast Injection Into the Stump Site of Amputees
Johns Hopkins University
NCT03947450
Assessing Ambulatory and Non-ambulatory Community Mobility in People With Lower Limb Amputation
Virginia Commonwealth University
NCT07387744
Target Muscle Re-innervation and Regenerative Peripheral Nerve Interfaces Alone and in Combination for the Treatment of Residual and Phantom Limb Pain in Cancer Patients Who Have Received an Amputation
M.D. Anderson Cancer Center
NCT06840262
Efficacy and Mechanisms of Virtual Reality Treatment of Phantom Leg Pain.Home-Based Treatment
Albert Einstein Healthcare Network
NCT07044323
Controlling Locomotion Over Continuously Varying Activities for Agile Powered Prosthetic Legs
University of Michigan
NCT06138977
Deploying Digital Prosthetic Interface Technology and Exercise in Dysvascular Amputees
Spaulding Rehabilitation Hospital
NCT05656924
Prosthetic Performance Enhancement Trial
University of Nevada, Las Vegas
NCT06419920
Comparing the Attentional Demands and Functional Outcomes in People With Transradial Amputation
Virginia Commonwealth University
NCT07075042
Effects of Myoelectric Channel Count and Targeting for Upper Limb Prosthetic Control
Liberating Technologies
NCT07011420
Clinical Outcomes With Non-Powered vs. Powered Prosthetic Knees by K2-level Amputees
Liberating Technologies
NCT06194838
AMI Construction in Lower Extremity Residual Limbs
Brigham and Women's Hospital
NCT04063592
Intuitive Control of a Hybrid Prosthetic Leg During Ambulation
Shirley Ryan AbilityLab
NCT04038151
Hybrid Pump Technology
VA Office of Research and Development
NCT04230512
Multicenter Trial Evaluating the Safety and Efficacy of Autologous Volar Fibroblast Injection Into the Terminal Limb of Amputees.
Major Extremity Trauma Research Consortium
NCT04839497
A Novel Approach to Upper Extremity Amputation to Augment Volitional Control and Restore Proprioception
Brigham and Women's Hospital
NCT03882073
Enhancing Motor Function in Individuals with Lower Limb Amputation
University of Nevada, Las Vegas
NCT06638723
Understanding How Powered Componentry Impacts K2-Level Transfemoral Amputee Gait
Shirley Ryan AbilityLab
NCT06433648
Detecting Change in Muscle Parameters, Pain, and Function With NMES for TTA
Sara Peterson-Snyder
NCT06830876
Impact of Improving Footwear Options
VA Office of Research and Development
NCT05601869
Study of Efficacy of the MyoTrain System in a Population of Individuals With Trans-radial Limb Loss
Infinite Biomedical Technologies
NCT05888428
Feasibility of Neural Feedback for Lower Limb Amputees
Louis Stokes VA Medical Center
NCT03409133
Short-term Implanted Electrodes Following Regenerative Peripheral Nerve Surgery for Improving Prosthetic Limb Control Signals
University of Michigan
NCT03260400
A Unique Body-Powered Terminal Device With Enhanced Grasping Capabilities for Individuals With Upper Limb Loss
Little Room Innovations
NCT07254247
Regulatory Clearance of the Glide Control Strategy for Upper Limb Prostheses
Infinite Biomedical Technologies
NCT06539936
Powered Prosthesis for Use With TF Osseointegration Recipients
Shirley Ryan AbilityLab
NCT06160882
Evaluation of Myoelectric Implantable Recording Array (MIRA) in Participants With Transradial Amputation
Boninger, Michael, MD
NCT05768802
Can an Array of Micro-electrodes Implanted in a Human Nerve Record Neural Signals and Provide Feedback?
University of Utah
NCT05505513
Regenerative Peripheral Nerve Interface for Control of Lower Limb Prostheses
University of Michigan
NCT06275282
Optimizing Prosthetic Prescription to Mitigate the Effects of Perspiration
VA Puget Sound Health Care System
NCT07024342
Personalized Mobility Interventions Using Smart Sensor Resources for Lower-Limb Prosthesis Users
Shirley Ryan AbilityLab
NCT03930199
VR to Evaluate Phantom Limb Pain
Shirley Ryan AbilityLab
NCT05915065
GaMA Metric to Quantify Functional Importance of Various Upper Limb Prosthetic Devices
Shirley Ryan AbilityLab
NCT06420687
Transfemoral Osseointegrated Prosthesis Limb-Load Symmetry Training
University of Colorado, Denver
NCT05695911
Tolerability and Feasibility Pilot Clinical Study of a Large-Diameter Nerve Cap for Protecting and Preserving Terminated Nerve Ends
Axogen Corporation
NCT04865679
Magnetic Bead Tracking System and eOPRA Implant System With Bionic Prosthesis for Transtibial Amputees
Brigham and Women's Hospital
NCT06391697
Development and Usability of an Adjustable Prosthesis for Aquatic Therapy
Shirley Ryan AbilityLab
NCT06259695
A Client-Based Outcome System for Individuals With Lower Limb Amputation
University of Washington
NCT01750372
Self-Management Program for Persons With Limb Loss
Johns Hopkins Bloomberg School of Public Health
NCT00198692
Understanding Prosthetic Needs and Outcomes in Women Veterans With Amputation
VA Office of Research and Development
NCT03733054
Dual-tasking for Individuals With Lower Limb Amputation: Exploring the Relationship to Falls and Instrumental Activities of Daily Living
VA Office of Research and Development
NCT05119192
Dysvascular Amputation Self-Management of Health
University of Colorado, Denver
NCT04083456
Comparative Effectiveness of Microprocessor Controlled and Carbon Fiber Prosthetic Feet in Transtibial Amputees
Ability Prosthetics and Orthotics
NCT02864693
A Wheelchair Propulsion Training Program
Washington University School of Medicine
NCT04009187
Upper Limb Loss Perturbation Response
VA Office of Research and Development
NCT04274218
Prosthetic Socket Interface Design on Socket Comfort, Residual Limb Health, and Function for the Transfemoral Amputee
University of South Florida
NCT02773056
Clinical Outcomes With Passive MPKs vs. Powered Prosthetic Knees
Liberating Technologies
NCT05267639
Does Walking Performance Improve When Veterans With Leg Amputations Are Given Visual Feedback?
VA Office of Research and Development
NCT03974945
Clinical Investigation (Beta) of a New Developed Prosthetic Knee
Össur Iceland ehf
NCT06748729
AMP30: Autologous Fat Grafting, Amputation Sites Pain: Randomized
J. Peter Rubin, MD
NCT02076022
Limb Health and Socket Pressure in Response to Powered Ankle Protheses
Indiana University
NCT05112679
No Power Bionic Lower Extremity Prosthesis
University of Michigan
NCT04070105
Biomechanical Evaluation of a Novel, Compliant Low Profile Prosthetic Foot
Little Room Innovations
NCT06468059
Assessing the DSR Ankle
Synchro Motion
NCT05955378
Reduction of Shear Forces Using Semi-flexible Sockets on Transtibial Amputees
Loma Linda University
NCT03390153
Myoelectric Game Training and Outcomes
Liberating Technologies
NCT04354493
RESCU System for Robust Upper Limb Prosthesis Control
Infinite Biomedical Technologies
NCT04043234
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 1 |
| Phase 2 | 5 |
| Phase 3 | 1 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Amputation Trial Landscape
ClinicalTrials.gov lists 66 US studies indexed under Amputation, and 38 of those are currently open to recruitment — roughly 58% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
The phase distribution for Amputation shows 1 late-stage studies (Phase 3 and Phase 4 combined) alongside 6 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
Top sponsor activity for Amputation is led by Shirley Ryan AbilityLab with 7 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 66 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Amputation?
PlainTrial tracks 66 US clinical trials for Amputation, of which 38 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Amputation?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology — how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.