Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Amputation: early-phase trial registry
38 of 66 indexed Amputation trials are currently recruiting, with more weight in Phase 1-2.
Corpus placement: #211 of 28,707 conditions by registered trial count.
66 US clinical trials · 38 currently recruiting · #211 of 28,707 conditions by registered trial count
Amputation: 66 US clinical trials tracked, 38 recruiting.
Amputation is the subject of 66 registered US clinical trials on ClinicalTrials.gov, 38 of them currently open to new participants. 1 are in Phase 3-4 (later-stage) and 6 in Phase 1-2 (earlier-stage). The most active sponsor is Shirley Ryan AbilityLab, running 7 of these trials.
Enrollment posture brief
Registry condition amputation
OPEN 38 | RECR 58% | LATE 1 | EARLY 6 | RANK #211 | SPON 7
Volume-matched condition peers
Nearest open-share peer: Overweight or Obesity (58% recruiting · 33 trials)
Amputation lists 38 open slots (58% of 66 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →
Key findings
What ClinicalTrials.gov does not surface for Amputation on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.
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Amputation is recruiting above its size-band peers.
38 of 66 indexed trials (57.6%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.
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Sponsorship of Amputation trials is spread across many organizations.
Shirley Ryan AbilityLab accounts for 7 of 66 trials (10.6%). 35 distinct sponsors appear on at least one study for this condition label.
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Most Amputation trials plan to enrol fewer than 100 people.
Median target enrolment is 20 among the 66 trials that report a genuine target (sentinel values excluded). 55 of those (83.3%) plan for fewer than 100 participants.
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Amputation research is mostly interventional.
59 interventional and 7 observational studies make up this index (89.4% interventional). Study type is sponsor-reported on ClinicalTrials.gov.
Open and recent trials
66 total, page 2 of 2
Dysvascular Amputation Self-Management of Health
University of Colorado, Denver
NCT04083456
Comparative Effectiveness of Microprocessor Controlled and Carbon Fiber Prosthetic Feet in Transtibial Amputees
Ability Prosthetics and Orthotics
NCT02864693
A Wheelchair Propulsion Training Program
Washington University School of Medicine
NCT04009187
Upper Limb Loss Perturbation Response
VA Office of Research and Development
NCT04274218
Prosthetic Socket Interface Design on Socket Comfort, Residual Limb Health, and Function for the Transfemoral Amputee
University of South Florida
NCT02773056
Clinical Outcomes With Passive MPKs vs. Powered Prosthetic Knees
Liberating Technologies
NCT05267639
Does Walking Performance Improve When Veterans With Leg Amputations Are Given Visual Feedback?
VA Office of Research and Development
NCT03974945
Clinical Investigation (Beta) of a New Developed Prosthetic Knee
Össur Iceland ehf
NCT06748729
AMP30: Autologous Fat Grafting, Amputation Sites Pain: Randomized
J. Peter Rubin, MD
NCT02076022
Limb Health and Socket Pressure in Response to Powered Ankle Protheses
Indiana University
NCT05112679
No Power Bionic Lower Extremity Prosthesis
University of Michigan
NCT04070105
Biomechanical Evaluation of a Novel, Compliant Low Profile Prosthetic Foot
Little Room Innovations
NCT06468059
Assessing the DSR Ankle
Synchro Motion
NCT05955378
Reduction of Shear Forces Using Semi-flexible Sockets on Transtibial Amputees
Loma Linda University
NCT03390153
Myoelectric Game Training and Outcomes
Liberating Technologies
NCT04354493
RESCU System for Robust Upper Limb Prosthesis Control
Infinite Biomedical Technologies
NCT04043234
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 1 |
| Phase 2 | 5 |
| Phase 3 | 1 |
Top Sponsors
Named interventions
Most-linked intervention names on Amputation records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.
US sites by state
Facility locations filed on Amputation trials. A trial with sites in several states counts in each.
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Related
What to do with this Amputation page
66 registered trials, 38 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.
- 38 Amputation trials are currently recruiting, check eligibility criteria before contacting a site. Browse recruiting trials
- Shirley Ryan AbilityLab sponsors the most Amputation trials on record, review their full trial history before evaluating a specific study. See Shirley Ryan AbilityLab's trials
- Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide
Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Amputation condition card totals 66 registered trials; most-linked intervention Attention Control; top US site state Illinois. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.