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ClinicalTrials.gov 19 recruiting now later-stage tilt

Overweight or Obesity: later-stage trial registry

19 of 33 indexed Overweight or Obesity trials are currently recruiting, with more weight in Phase 3-4.

Corpus placement: #463 of 28,707 conditions by registered trial count.

33 US clinical trials · 19 currently recruiting · #463 of 28,707 conditions by registered trial count

Overweight or Obesity: 33 US clinical trials tracked, 19 recruiting.

Overweight or Obesity is the subject of 33 registered US clinical trials on ClinicalTrials.gov, 19 of them currently open to new participants. 8 are in Phase 3-4 (later-stage) and 5 in Phase 1-2 (earlier-stage). The most active sponsor is Eli Lilly and Company, running 8 of these trials.

Enrollment posture brief

Registry condition overweight-or-obesity

OPEN 19 | RECR 58% | LATE 8 | EARLY 5 | RANK #463 | SPON 8

Nearest open-share peer: Amputation (58% recruiting · 66 trials)

Overweight or Obesity (this)58%Barrett Esophagus54.5%Clinical Stage IV Cutaneous 45.5%Child Development39.4%Anatomic Stage IIB Breast Ca24.2%
Open-enrollment share among volume-matched conditions near Overweight or Obesity

Overweight or Obesity lists 19 open slots (58% of 33 indexed trials). Peers are matched on registered volume, not therapeutic-area browse lists. How peer matching works →

Key findings

What ClinicalTrials.gov does not surface for Overweight or Obesity on its own pages , computed from the registry mirror as of 2026-08-08. Each line carries its own denominator so it can be quoted as it stands.

  1. Overweight or Obesity is recruiting above its size-band peers.

    19 of 33 indexed trials (57.6%) are open to enrollment, against a 39.7% average across 762 conditions with 20-99 trials. The peer set uses the same ClinicalTrials.gov-derived counts as this page.

  2. One sponsor concentrates Overweight or Obesity research.

    Eli Lilly and Company accounts for 8 of 33 trials (24.2%). 20 distinct sponsors appear on at least one study for this condition label.

  3. Typical Overweight or Obesity enrolment sits around 200 participants.

    Median target enrolment is 200 among the 33 trials that report a genuine target (sentinel values excluded). 9 of those (27.3%) plan for fewer than 100 participants.

  4. Overweight or Obesity research is mostly interventional.

    29 interventional and 4 observational studies make up this index (87.9% interventional). Study type is sponsor-reported on ClinicalTrials.gov.

Phase 12Phase 23Phase 36Phase 42

Open and recent trials

33 total, page 1 of 1

RECRUITING 1,000,000 participants

Healthy Living BEYOND Weight Study

American Heart Association

NCT07075341

RECRUITING Phase 2 1,785 participants

Taxi ROADmAP (Realizing Optimization Around Diet And Physical Activity)

Memorial Sloan Kettering Cancer Center

NCT05770570

RECRUITING 1,000 participants

Community Park-Based Programs for Health Promotion: The Fit2Lead Prospective Cohort Study

Duke University

NCT06596265

RECRUITING Phase 3 900 participants

Efficacy and Safety of Eloralintide (LY3841136) in Participants With Osteoarthritis Knee Pain and Obesity or Overweight

Eli Lilly and Company

NCT07353931

RECRUITING Phase 3 487 participants

A Master Protocol Study of Orforglipron (LY3502970) in Participants With Hypertension and Obesity or Overweight (ATTAIN-Hypertension) GZL1

Eli Lilly and Company

NCT06948435

RECRUITING NA 403 participants

NDPP-NextGen: A Clinical Trial to Reduce Intergenerational Obesity and Diabetes Risks

Wake Forest University Health Sciences

NCT05674799

RECRUITING NA 280 participants

eMOTION: Examining Affective Mechanisms in Physical Activity Engagement

University of Southern California

NCT06570642

RECRUITING NA 212 participants

Promote Weight Loss in Obese Peripheral Artery Disease (PAD) Patients to Prevent Mobility Loss

Northwestern University

NCT04228978

RECRUITING Phase 4 200 participants

A Study to Investigate Effectiveness of Tirzepatide Following Initiation of Ixekizumab in Participants With Active Psoriatic Arthritis and Overweight or Obesity in Clinical Practice (TOGETHER AMPLIFY-PsA)

Eli Lilly and Company

NCT06864026

RECRUITING Phase 3 200 participants

Semaglutide for Metabolic Intervention and Adipose Loss to Treat Atrial Fibrillation

University of Chicago

NCT06499857

RECRUITING Phase 4 200 participants

A Study to Investigate the Effectiveness of Tirzepatide (LY3298176) Following Initiation of Ixekizumab (LY2439821) in Participants With Moderate-to-Severe Plaque PsO and Obesity or Overweight in Clinical Practice (TOGETHER AMPLIFY-PsO)

Eli Lilly and Company

NCT06857942

RECRUITING NA 150 participants

Better Lifestyle Counseling for African American Women During Pregnancy

University of Illinois at Chicago

NCT05234125

RECRUITING Phase 1 144 participants

A Study of LY4064912 in Healthy Participants and With Overweight or Obesity

Eli Lilly and Company

NCT07152002

RECRUITING 120 participants

eMOTION: Examining Implicit Attitudes in Physical Activity Engagement

University of Southern California

NCT07044570

RECRUITING Phase 1 60 participants

Evaluate the Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of BGM1812 Injection Following Single and Multiple Subcutaneous Administration in Normal to Overweight or Obese But Otherwise Healthy Men and Women

BrightGene Bio-Medical Technology Co.

NCT07224399

RECRUITING NA 50 participants

Craving Network Neurofeedback

Yale University

NCT06426693

RECRUITING NA 36 participants

Remotely Delivered Resistance Training for Cardiometabolic Health Among Black Women

University of Alabama at Birmingham

NCT06360536

RECRUITING NA 30 participants

Postprandial Effects of Animal Versus Plant-Based Protein

Ball State University

NCT06445296

RECRUITING NA 20 participants

The Acute T-Rex (Timing of Resistance Exercise) Study

University of Utah

NCT06366399

ACTIVE NOT RECRUITING Phase 3 3,127 participants

A Study of Orforglipron (LY3502970) in Adult Participants With Obesity or Overweight With Weight-Related Comorbidities

Eli Lilly and Company

NCT05869903

ACTIVE NOT RECRUITING Phase 3 2,749 participants

A Study of Daily Oral Orforglipron (LY3502970) Compared With Insulin Glargine in Participants With Type 2 Diabetes and Obesity or Overweight at Increased Cardiovascular Risk

Eli Lilly and Company

NCT05803421

ACTIVE NOT RECRUITING Phase 3 600 participants

A Master Protocol for Orforglipron in Participants With Obstructive Sleep Apnea and Obesity or Overweight

Eli Lilly and Company

NCT06649045

ACTIVE NOT RECRUITING 500 participants

Biological Sample Repository for Gastrointestinal Disorders

Pichamol Jirapinyo, MD, MPH

NCT05874726

ACTIVE NOT RECRUITING Phase 2 250 participants

A Phase 2b Study to Evaluate the Efficacy and Safety of Once-Monthly MET097 in Adults With Obesity or Overweight

Metsera, a wholly owned subsidiary of Pfizer

NCT06973720

ACTIVE NOT RECRUITING Phase 2 225 participants

A Phase 2b Study to Examine the Safety and Efficacy of Once-Weekly MET097 in Adults With Obesity or Overweight

Metsera, a wholly owned subsidiary of Pfizer

NCT06712836

ACTIVE NOT RECRUITING NA 174 participants

Technology-Supported Treatment of Sleep Apnea in Prediabetes

University of Chicago

NCT04225507

ACTIVE NOT RECRUITING NA 105 participants

Berries, Inflammation, and Gut Microbiome

Clinical Nutrition Research Center, Illinois Institute of Technology

NCT04100200

ACTIVE NOT RECRUITING NA 103 participants

Pulses Consumption and Its Role in Managing Systemic Inflammation, Insulin Sensitivity and Gut Microbiome in Human

Clinical Nutrition Research Center, Illinois Institute of Technology

NCT04267705

ACTIVE NOT RECRUITING NA 30 participants

Hepatic Energy Fluxes in NASH and NAS Patients

University of Minnesota

NCT03997422

ACTIVE NOT RECRUITING NA 25 participants

Functional Fitness for Overweight or Obese Adults with Mobility Disabilities

University of Kansas

NCT05880966

COMPLETED NA 580 participants

Indigenous Supported Agriculture "Go Healthy"

Oklahoma State University Center for Health Sciences

NCT05773833

COMPLETED NA 47 participants

eMOTION Formative Study

University of Southern California

NCT06125964

COMPLETED NA 8 participants

Binge Eating Self-help for Teens ONLINE Pilot and Feasibility Study

Yale University

NCT06107387

Phase Distribution

PhaseTrial count
Phase 1 2
Phase 2 3
Phase 3 6
Phase 4 2

Named interventions

Most-linked intervention names on Overweight or Obesity records (sponsor-reported on ClinicalTrials.gov). Counts are trial links, not unique products.

Placebo Drug
9 trials
Orforglipron Drug
4 trials
SAVOR enhancement Behavioral
2 trials
TYPE/CONTEXT enhancement Behavioral
2 trials
Physical Activity Goals mHealth Intervention Behavioral
2 trials
MET097 Drug
2 trials
Tirzepatide Drug
2 trials
SAVOR Enhancement Behavioral
1 trials

US sites by state

Facility locations filed on Overweight or Obesity trials. A trial with sites in several states counts in each.

California 12 trials
Illinois 7 trials
Florida 7 trials
Arizona 7 trials
Georgia 5 trials
Maryland 4 trials
Massachusetts 4 trials
Texas 3 trials

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

What to do with this Overweight or Obesity page

33 registered trials, 19 currently recruiting, is a starting point for a conversation, not a diagnosis or a recommendation.

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This Overweight or Obesity condition card totals 33 registered trials; most-linked intervention Placebo; top US site state California. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.