Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

2026 data Public-data reference. official source

Overweight or Obesity

Open-data reference.

33 US clinical trials · 19 currently recruiting

Active & Recent Trials

RECRUITING 1,000,000 participants

Healthy Living BEYOND Weight Study

American Heart Association

NCT07075341

RECRUITING Phase 2 1,785 participants

Taxi ROADmAP (Realizing Optimization Around Diet And Physical Activity)

Memorial Sloan Kettering Cancer Center

NCT05770570

RECRUITING 1,000 participants

Community Park-Based Programs for Health Promotion: The Fit2Lead Prospective Cohort Study

Duke University

NCT06596265

RECRUITING Phase 3 900 participants

Efficacy and Safety of Eloralintide (LY3841136) in Participants With Osteoarthritis Knee Pain and Obesity or Overweight

Eli Lilly and Company

NCT07353931

RECRUITING Phase 3 487 participants

A Master Protocol Study of Orforglipron (LY3502970) in Participants With Hypertension and Obesity or Overweight (ATTAIN-Hypertension) GZL1

Eli Lilly and Company

NCT06948435

RECRUITING NA 403 participants

NDPP-NextGen: A Clinical Trial to Reduce Intergenerational Obesity and Diabetes Risks

Wake Forest University Health Sciences

NCT05674799

RECRUITING NA 280 participants

eMOTION: Examining Affective Mechanisms in Physical Activity Engagement

University of Southern California

NCT06570642

RECRUITING NA 212 participants

Promote Weight Loss in Obese Peripheral Artery Disease (PAD) Patients to Prevent Mobility Loss

Northwestern University

NCT04228978

RECRUITING Phase 4 200 participants

A Study to Investigate Effectiveness of Tirzepatide Following Initiation of Ixekizumab in Participants With Active Psoriatic Arthritis and Overweight or Obesity in Clinical Practice (TOGETHER AMPLIFY-PsA)

Eli Lilly and Company

NCT06864026

RECRUITING Phase 3 200 participants

Semaglutide for Metabolic Intervention and Adipose Loss to Treat Atrial Fibrillation

University of Chicago

NCT06499857

RECRUITING Phase 4 200 participants

A Study to Investigate the Effectiveness of Tirzepatide (LY3298176) Following Initiation of Ixekizumab (LY2439821) in Participants With Moderate-to-Severe Plaque PsO and Obesity or Overweight in Clinical Practice (TOGETHER AMPLIFY-PsO)

Eli Lilly and Company

NCT06857942

RECRUITING NA 150 participants

Better Lifestyle Counseling for African American Women During Pregnancy

University of Illinois at Chicago

NCT05234125

RECRUITING Phase 1 144 participants

A Study of LY4064912 in Healthy Participants and With Overweight or Obesity

Eli Lilly and Company

NCT07152002

RECRUITING 120 participants

eMOTION: Examining Implicit Attitudes in Physical Activity Engagement

University of Southern California

NCT07044570

RECRUITING Phase 1 60 participants

Evaluate the Pharmacokinetics, Pharmacodynamics, Safety and Tolerability of BGM1812 Injection Following Single and Multiple Subcutaneous Administration in Normal to Overweight or Obese But Otherwise Healthy Men and Women

BrightGene Bio-Medical Technology Co.

NCT07224399

RECRUITING NA 50 participants

Craving Network Neurofeedback

Yale University

NCT06426693

RECRUITING NA 36 participants

Remotely Delivered Resistance Training for Cardiometabolic Health Among Black Women

University of Alabama at Birmingham

NCT06360536

RECRUITING NA 30 participants

Postprandial Effects of Animal Versus Plant-Based Protein

Ball State University

NCT06445296

RECRUITING NA 20 participants

The Acute T-Rex (Timing of Resistance Exercise) Study

University of Utah

NCT06366399

ACTIVE NOT RECRUITING Phase 3 3,127 participants

A Study of Orforglipron (LY3502970) in Adult Participants With Obesity or Overweight With Weight-Related Comorbidities

Eli Lilly and Company

NCT05869903

ACTIVE NOT RECRUITING Phase 3 2,749 participants

A Study of Daily Oral Orforglipron (LY3502970) Compared With Insulin Glargine in Participants With Type 2 Diabetes and Obesity or Overweight at Increased Cardiovascular Risk

Eli Lilly and Company

NCT05803421

ACTIVE NOT RECRUITING Phase 3 600 participants

A Master Protocol for Orforglipron in Participants With Obstructive Sleep Apnea and Obesity or Overweight

Eli Lilly and Company

NCT06649045

ACTIVE NOT RECRUITING 500 participants

Biological Sample Repository for Gastrointestinal Disorders

Pichamol Jirapinyo, MD, MPH

NCT05874726

ACTIVE NOT RECRUITING Phase 2 250 participants

A Phase 2b Study to Evaluate the Efficacy and Safety of Once-Monthly MET097 in Adults With Obesity or Overweight

Metsera, a wholly owned subsidiary of Pfizer

NCT06973720

ACTIVE NOT RECRUITING Phase 2 225 participants

A Phase 2b Study to Examine the Safety and Efficacy of Once-Weekly MET097 in Adults With Obesity or Overweight

Metsera, a wholly owned subsidiary of Pfizer

NCT06712836

ACTIVE NOT RECRUITING NA 174 participants

Technology-Supported Treatment of Sleep Apnea in Prediabetes

University of Chicago

NCT04225507

ACTIVE NOT RECRUITING NA 105 participants

Berries, Inflammation, and Gut Microbiome

Clinical Nutrition Research Center, Illinois Institute of Technology

NCT04100200

ACTIVE NOT RECRUITING NA 103 participants

Pulses Consumption and Its Role in Managing Systemic Inflammation, Insulin Sensitivity and Gut Microbiome in Human

Clinical Nutrition Research Center, Illinois Institute of Technology

NCT04267705

ACTIVE NOT RECRUITING NA 30 participants

Hepatic Energy Fluxes in NASH and NAS Patients

University of Minnesota

NCT03997422

ACTIVE NOT RECRUITING NA 25 participants

Functional Fitness for Overweight or Obese Adults with Mobility Disabilities

University of Kansas

NCT05880966

COMPLETED NA 580 participants

Indigenous Supported Agriculture "Go Healthy"

Oklahoma State University Center for Health Sciences

NCT05773833

COMPLETED NA 47 participants

eMOTION Formative Study

University of Southern California

NCT06125964

COMPLETED NA 8 participants

Binge Eating Self-help for Teens ONLINE Pilot and Feasibility Study

Yale University

NCT06107387

Phase Distribution

PhaseTrial count
Early Phase 1 2
Phase 2 3
Phase 3 6
Phase 4 2

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Overweight or Obesity Trial Landscape

ClinicalTrials.gov lists 33 US studies indexed under Overweight or Obesity, and 19 of those are currently open to recruitment — roughly 58% of the total volume on the registry. That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

The phase distribution for Overweight or Obesity shows 8 late-stage studies (Phase 3 and Phase 4 combined) alongside 5 earlier-phase entries (Phase 1 through Phase 2). Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

Top sponsor activity for Overweight or Obesity is led by Eli Lilly and Company with 8 indexed trials, alongside 9 other organizations in the top contributor list. The list on this page surfaces up to 33 of the most relevant recent and active entries, ordered with recruiting studies first so practical options are visible. All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation — eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Overweight or Obesity?

PlainTrial tracks 33 US clinical trials for Overweight or Obesity, of which 19 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Overweight or Obesity?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2024 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →