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Alzheimer Disease clinical trials
155 of 312 indexed Alzheimer Disease trials are currently recruiting.
312 US clinical trials · 155 currently recruiting
Alzheimer Disease is the subject of 312 registered US clinical trials on ClinicalTrials.gov, 155 of them currently open to new participants. 26 are in Phase 3-4 (later-stage) and 104 in Phase 1-2 (earlier-stage). The most active sponsor is Eli Lilly and Company, running 13 of these trials.
The research picture
Alzheimer Disease has 312 registered US clinical trials, 155 of them open to new participants right now, about 50% of the total.
- 155
- recruiting participants now
- 50%
- of trials open to enrollment
- 26
- in Phase 3–4 (later-stage)
- 13
- top sponsor: Eli Lilly and Company
Active & Recent Trials
312 total, page 5 of 7
Fasting ENHANCE Pilot Study
University of Florida
NCT05732935
Efficacy of Caregiver Training Program in Enhancing Caregiver and Patient Outcomes
MapHabit
NCT05527405
Study of AV-1959D, an Amyloid Beta Vaccine
Institute for Molecular Medicine
NCT05642429
Does EVOO Induce Gene and Metabolic Changes in Healthy Subjects
Augusta University
NCT05929924
The Use of Memantine for Prevention of Alzheimer's Disease
University of Virginia
NCT05063851
Study in Subjects With Mild-to-Moderate Alzheimer's Dementia
Alzamend Neuro
NCT05834296
ALSENLITE: Senolytics for Alzheimer's Disease
Mayo Clinic
NCT04785300
Cholinergic Integrity in Down Syndrome in Association With Aging, Alzheimer's Disease Pathology, and Cognition
Vanderbilt University Medical Center
NCT05231798
Daily Light and Sound Stimulation to Improve Brain Functions in Alzheimer's Disease
Massachusetts Institute of Technology
NCT04055376
Long-Term Follow-up of Gene Therapy for APOE4 Homozygote Alzheimer's Disease
Lexeo Therapeutics
NCT05400330
The Effect of De-Prescribing Antipsychotics on Health and Quality of Life for People With Dementia
Columbia University
NCT05172687
Aligning Patient Preferences: a Role Offering Alzheimer's Patients, Caregivers, and Healthcare Providers Education and Support
Indiana University
NCT03323502
A Program to Reduce Inappropriate Medications Among Older Adults With Alzheimer's Disease: Implementation Phase 2
University of Massachusetts, Worcester
NCT06368115
Comparative Efficacy, Safety, and Tolerability of Rivastigmine 10 and 15 cm^2 Patch in Patients With Alzheimer's Disease (AD) Showing Cognitive Decline
Novartis Pharmaceuticals
NCT00506415
Utilizing Palliative Leaders In Facilities to Transform Care for Alzheimer's Disease
Indiana University
NCT04520698
Aging Brain Care Virtual Program
Indiana University
NCT06245499
BI 425809 in Patients With Cognitive Impairment Due to Alzheimer's Disease.
Boehringer Ingelheim
NCT02788513
Caregiver Speaks: A Technologically Mediated Storytelling Intervention
Washington University School of Medicine
NCT04103580
A Study to Assess the Long-term Safety and Efficacy of AXS-05 in Subjects With Alzheimer's Disease Agitation
Axsome Therapeutics
NCT04947553
Decisions About Cancer Screening in Alzheimer's Disease
Indiana University
NCT03282097
Information About Alzheimer's Disease for Latinos in New York City
Columbia University
NCT04471779
Quality Improvement PrecivityAD Clinician Survey (QUIP I)
C2N Diagnostics
NCT05477056
Enhanced Quality in Primary Care for Elders With Diabetes and Dementia
NYU Langone Health
NCT03723707
ELND005 in Patients With Mild to Moderate Alzheimer's Disease
OPKO Health
NCT00568776
Study of BHV-4157 in Alzheimer's Disease
Biohaven Pharmaceuticals
NCT03605667
A Study of LY3372689 to Assess the Safety, Tolerability, and Efficacy in Participants With Alzheimer's Disease
Eli Lilly and Company
NCT05063539
A Study of LY3002813 in Participants With Early Symptomatic Alzheimer's Disease (TRAILBLAZER-ALZ)
Eli Lilly and Company
NCT03367403
Improving the Recovery and Outcome Every Day After the ICU
Indiana University
NCT03095417
A Reader Study to Assess Accuracy and Reliability of Flortaucipir F 18 Positron Emission Tomography (PET) Scan Interpretation
Avid Radiopharmaceuticals
NCT03901092
Accelerated Non-Atherosclerotic Brain Arterial Aging Relationship to Alzheimer's Disease
Jose Gutierrez, MD, MPH
NCT04510168
In-Home Technology for Caregivers of People With Dementia and Mild Cognitive Impairment
University of California, Berkeley
NCT04206670
A Dyadic Approach for a Remote Physical Activity Intervention in Adults With AD and Their Caregivers
University of Kansas
NCT04102514
Technology and Family Thriving Study
University of California, Santa Barbara
NCT05150990
LEAD IT! An App to Enable Persons With Early Stage Dementia to Lead Group Activities for Their Peers
Hopeful Aging
NCT05516342
A Relational Research Recruitment and Engagement Intervention for Cognitive Aging Research
University of Wisconsin, Madison
NCT05444244
Antipsychotic Discontinuation in Alzheimer's Disease
New York State Psychiatric Institute
NCT00417482
Enriching Clinical Trials Requiring Amyloid Positivity With Practice Effects
University of Utah
NCT03466736
Caring Light Project for Family Caregivers
Photozig
NCT04517877
Proof-of-Concept Study of a Selective p38 MAPK Alpha Inhibitor, Neflamapimod, in Subjects With Mild Alzheimer's Disease
EIP Pharma
NCT03402659
Alzheimer's PET Imaging in Racially/Ethnically Diverse Adults
Adam Brickman
NCT03706261
Cognitive Decline and Alzheimer's Disease in the Dallas Lifespan Brain Study
Neil M Rofsky, MD, MHA
NCT04080544
A Phase 1, Corplex™ Donepezil Transdermal System Compared to Oral Aricept®
Corium
NCT02968719
Study to Assess the Safety and Biological Activity of AMX0035 for the Treatment of Alzheimer's Disease
Amylyx Pharmaceuticals
NCT03533257
A Follow-On Study of Donanemab (LY3002813) With Video Assessments in Participants With Alzheimer's Disease (TRAILBLAZER-EXT)
Eli Lilly and Company
NCT04640077
A Study of Seltorexant in Participants With Probable Alzheimer's Disease
Janssen Research & Development
NCT05307692
Community-based Brain Health Program to Address Dementia Risk
Posit Science Corporation
NCT05529706
Therapeutic Diets in Alzheimer's Disease
University of Kansas Medical Center
NCT03860792
Automated Retinal Image Analysis System (EyeQuant) for Computation of Vascular Biomarkers
Mayo Clinic
NCT04567745
Harmony at Home: A Pilot Telehealth Program for Rural ADRD Caregivers
Elizabeth K Rhodus
NCT05202223
Caregiver Study Dr. Phillips
AdventHealth
NCT03653871
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 53 |
| Phase 2 | 51 |
| Phase 3 | 18 |
| Phase 4 | 8 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Alzheimer Disease Trial Landscape
312 indexed Alzheimer Disease studies · 155 recruiting (50%).
Phase mix: 26 late (III/IV) vs 104 early (I/II).
Top sponsor: Eli Lilly and Company (13 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Alzheimer Disease?
PlainTrial tracks 312 US clinical trials for Alzheimer Disease, of which 155 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Alzheimer Disease?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.