Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.

ClinicalTrials.gov 155 recruiting now official registry

Alzheimer Disease clinical trials

155 of 312 indexed Alzheimer Disease trials are currently recruiting.

312 US clinical trials · 155 currently recruiting

Alzheimer Disease is the subject of 312 registered US clinical trials on ClinicalTrials.gov, 155 of them currently open to new participants. 26 are in Phase 3-4 (later-stage) and 104 in Phase 1-2 (earlier-stage). The most active sponsor is Eli Lilly and Company, running 13 of these trials.

The research picture

Alzheimer Disease has 312 registered US clinical trials, 155 of them open to new participants right now, about 50% of the total.

155
recruiting participants now
50%
of trials open to enrollment
26
in Phase 3–4 (later-stage)
13
top sponsor: Eli Lilly and Company
Phase 153Phase 251Phase 318Phase 48

Active & Recent Trials

312 total, page 6 of 7

COMPLETED Phase 1 69 participants

A Phase I Study for Safety and Tolerability of AL002.

Alector

NCT03635047

COMPLETED 65 participants

Eye to Brain Connection

Optina Diagnostics

NCT05215782

COMPLETED Phase 1 63 participants

A Study of LY3002813 in Participants With Alzheimer's Disease

Eli Lilly and Company

NCT01837641

COMPLETED Phase 1 61 participants

A Study of LY3002813 in Participants With Memory Damage Due to Alzheimer's Disease (AD) or AD

Eli Lilly and Company

NCT02624778

COMPLETED NA 60 participants

Acute Exercise and the Cerebral Metabolic Response in Aging and Alzheimer's Disease

University of Kansas Medical Center

NCT04299308

COMPLETED NA 60 participants

Powerful Tools for Caregivers of Dementia Patients

Florida State University

NCT02697721

COMPLETED 59 participants

11C-PIB PET Study in MESA at Columbia University

José A. Luchsinger

NCT03981380

COMPLETED Phase 1 56 participants

Phase1a, Dose-escalation Study of NNI-362 in Healthy Aged Volunteers

Neuronascent

NCT04074837

COMPLETED 54 participants

Evaluating the Relationship Between Tau PET Imaging and CSF Biomarkers of AD (Alzheimer Disease) in Humans

Tammie L. S. Benzinger, MD, PhD

NCT03287765

COMPLETED NA 50 participants

Telehealth-enabled Integrated Palliative Care for People With Dementia

Thomas Jefferson University

NCT05524181

COMPLETED NA 48 participants

Telomerase Activator and Retinal Amyloid

Chippewa Valley Eye Clinic

NCT02530255

COMPLETED Phase 2 47 participants

SNIFF - Combo INI+EMPA Trial

Wake Forest University Health Sciences

NCT05081219

COMPLETED Phase 1 43 participants

Effect of CT1812 Treatment on Brain Synaptic Density

Cognition Therapeutics

NCT03493282

COMPLETED Phase 1 40 participants

Salsalate in Patients Mild to Moderate Alzheimer's Disease

Adam Boxer

NCT03277573

COMPLETED 40 participants

Brain Imaging in Alzheimer's Disease

National Institute of Mental Health (NIMH)

NCT00039702

COMPLETED NA 38 participants

Assessing a Novel Virtual Environment That Assists With Activities of Daily Living

mandy

NCT05418296

COMPLETED Early Phase 1 36 participants

Exploratory Evaluation of Flortaucipir Injection in Healthy Volunteers and Cognitively Impaired Subjects

Avid Radiopharmaceuticals

NCT04474405

COMPLETED Phase 1 36 participants

Virtual Reality Cognitive Therapy for Alzheimer's Disease

Claritytek

NCT05788848

COMPLETED NA 30 participants

At-Home Telehealth Yoga for Treating Chronic Pain in People With Alzheimer's Disease and Their Caregiver's

Palo Alto Veterans Institute for Research

NCT04512040

COMPLETED NA 30 participants

Socially Isolated Older Adults Living With Dementia

University of Washington

NCT03666624

COMPLETED Phase 1 30 participants

Drug-Drug Interaction (DDI) w/Ketoconazole or Fluconazole

Bristol-Myers Squibb

NCT00860275

COMPLETED NA 29 participants

The Cognitive Resilience Study

Duke University

NCT03016702

COMPLETED 27 participants

Developing Advanced Blood-Brain Barrier Permeability Imaging for Early AD

NYU Langone Health

NCT03389698

COMPLETED Phase 2 26 participants

Evaluation of 123-I Iodobenzovesamicol (IBVM) and SPECT Imaging of Healthy Subjects and Patients With Alzheimer Disease

Institute for Neurodegenerative Disorders

NCT00480701

COMPLETED NA 25 participants

Movement Intervention for Memory Enhancement

Albert Einstein College of Medicine

NCT03475316

COMPLETED Phase 1 24 participants

Allopregnanolone for Mild Cognitive Impairment Due to Alzheimer's Disease or Mild AD

University of Southern California

NCT02221622

COMPLETED NA 24 participants

Brain Vascular and Neurocognitive Health

The University of Texas at Arlington

NCT06497413

COMPLETED Phase 1 24 participants

A Safety Study of PTI-125 in Healthy Volunteers

Pain Therapeutics

NCT03784300

COMPLETED Phase 1 24 participants

Multiple Dose Study Evaluating the Safety and Tolerability of NSA-789

Wyeth is now a wholly owned subsidiary of Pfizer

NCT00795730

COMPLETED Phase 1 23 participants

Transcranial Magnetic Stimulation and Constraint Induced Language Therapy for Alzheimer Disease

University of Pennsylvania

NCT04482179

COMPLETED Phase 1 20 participants

Evaluation of [123I] AV51 and SPECT as a Marker of Beta-amyloid Protein Deposition in Subjects With Alzheimer Disease in Comparison to Healthy Subjects

Institute for Neurodegenerative Disorders

NCT00556660

COMPLETED Phase 1 20 participants

A Study of Two Doses of 18F-AV-45 in Alzheimer's Disease and Healthy Volunteers

Avid Radiopharmaceuticals

NCT01565330

COMPLETED NA 20 participants

Zolpidem CR and Hospitalized Patients With Dementia

Massachusetts General Hospital

NCT00814502

COMPLETED NA 20 participants

Improving Sleep and Cognition in Alzheimer's Disease

Emory University

NCT05200208

COMPLETED NA 18 participants

Rhythmically Entrained Exercise in Community-Dwelling Older Adults

University of North Carolina, Greensboro

NCT05462977

COMPLETED Phase 1 17 participants

Neurodegenerative Alzheimer's Disease and Amyotrophic Lateral Sclerosis (NADALS) Basket Trial

Massachusetts General Hospital

NCT05189106

COMPLETED NA 15 participants

In-Home Technology for Caregivers of People With Dementia and Mild Cognitive Impairment: Rural Homes

University of California, Berkeley

NCT05159583

COMPLETED Phase 2 15 participants

A Trial to Evaluate the Effects of BCG in Adults With MCI and Mild-to-Moderate AD

Steven E Arnold, MD

NCT05004688

COMPLETED Phase 1 14 participants

A Phase 1 Study To Evaluate The Effect Of Dimebon On The Pharmacokinetics Of Dextromethorphan

Pfizer

NCT00788047

COMPLETED NA 14 participants

Our Care Wishes - Dementia

University of Pennsylvania

NCT05033262

COMPLETED Phase 4 12 participants

Magnetic Resonance Spectroscopy Study of Memantine in Alzheimer's Disease

Northwell Health

NCT00551161

COMPLETED NA 11 participants

Network Modulation in Alzheimer's Disease

Brigham and Women's Hospital

NCT04045990

COMPLETED Phase 1 11 participants

Treatment of Language and Memory in Patients With Alzheimer's Disease

University of Arkansas

NCT00593372

COMPLETED Phase 4 11 participants

Low-Dose Opiate Therapy for Discomfort in Dementia (L-DOT)

VA Office of Research and Development

NCT00385684

COMPLETED Early Phase 1 10 participants

Phase 1 Evaluation of [18F]MK-6240 PET as an Imaging Marker for Tau Protein

Invicro

NCT03071224

COMPLETED Early Phase 1 10 participants

Cognition, Age, and RaPamycin Effectiveness - DownregulatIon of thE mTor Pathway

The University of Texas Health Science Center at San Antonio

NCT04200911

COMPLETED Phase 1 9 participants

Imaging Inflammation in Alzheimer's Disease With 11C-ER176

Columbia University

NCT03744312

COMPLETED Phase 1 8 participants

A Study to Assess Safety and Target Engagement of E2814 in Participants With Mild to Moderate Cognitive Impairment Due to Dominantly Inherited Alzheimer's Disease

Eisai

NCT04971733

COMPLETED NA 8 participants

Safety and Efficacy of Transcranial Electromagnetic Treatment Against Alzheimer's Disease

NeuroEM Therapeutics

NCT02958930

COMPLETED Phase 1 6 participants

Alzheimer's Disease Stem Cells Multiple Infusions

Bernard (Barry) Baumel

NCT04040348

← Previous Page 6 of 7 Next →

Phase Distribution

PhaseTrial count
Phase 1 53
Phase 2 51
Phase 3 18
Phase 4 8

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Alzheimer Disease Trial Landscape

312 indexed Alzheimer Disease studies · 155 recruiting (50%).

Phase mix: 26 late (III/IV) vs 104 early (I/II).

Top sponsor: Eli Lilly and Company (13 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Alzheimer Disease?

PlainTrial tracks 312 US clinical trials for Alzheimer Disease, of which 155 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Alzheimer Disease?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.