Medical Information Only. Consult your healthcare provider before considering clinical trial enrollment.
Alzheimer Disease clinical trials
155 of 312 indexed Alzheimer Disease trials are currently recruiting.
312 US clinical trials · 155 currently recruiting
Alzheimer Disease is the subject of 312 registered US clinical trials on ClinicalTrials.gov, 155 of them currently open to new participants. 26 are in Phase 3-4 (later-stage) and 104 in Phase 1-2 (earlier-stage). The most active sponsor is Eli Lilly and Company, running 13 of these trials.
The research picture
Alzheimer Disease has 312 registered US clinical trials, 155 of them open to new participants right now, about 50% of the total.
- 155
- recruiting participants now
- 50%
- of trials open to enrollment
- 26
- in Phase 3–4 (later-stage)
- 13
- top sponsor: Eli Lilly and Company
Active & Recent Trials
312 total, page 6 of 7
A Phase I Study for Safety and Tolerability of AL002.
Alector
NCT03635047
Eye to Brain Connection
Optina Diagnostics
NCT05215782
A Study of LY3002813 in Participants With Alzheimer's Disease
Eli Lilly and Company
NCT01837641
A Study of LY3002813 in Participants With Memory Damage Due to Alzheimer's Disease (AD) or AD
Eli Lilly and Company
NCT02624778
Acute Exercise and the Cerebral Metabolic Response in Aging and Alzheimer's Disease
University of Kansas Medical Center
NCT04299308
Powerful Tools for Caregivers of Dementia Patients
Florida State University
NCT02697721
11C-PIB PET Study in MESA at Columbia University
José A. Luchsinger
NCT03981380
Phase1a, Dose-escalation Study of NNI-362 in Healthy Aged Volunteers
Neuronascent
NCT04074837
Evaluating the Relationship Between Tau PET Imaging and CSF Biomarkers of AD (Alzheimer Disease) in Humans
Tammie L. S. Benzinger, MD, PhD
NCT03287765
Telehealth-enabled Integrated Palliative Care for People With Dementia
Thomas Jefferson University
NCT05524181
Telomerase Activator and Retinal Amyloid
Chippewa Valley Eye Clinic
NCT02530255
SNIFF - Combo INI+EMPA Trial
Wake Forest University Health Sciences
NCT05081219
Effect of CT1812 Treatment on Brain Synaptic Density
Cognition Therapeutics
NCT03493282
Salsalate in Patients Mild to Moderate Alzheimer's Disease
Adam Boxer
NCT03277573
Brain Imaging in Alzheimer's Disease
National Institute of Mental Health (NIMH)
NCT00039702
Assessing a Novel Virtual Environment That Assists With Activities of Daily Living
mandy
NCT05418296
Exploratory Evaluation of Flortaucipir Injection in Healthy Volunteers and Cognitively Impaired Subjects
Avid Radiopharmaceuticals
NCT04474405
Virtual Reality Cognitive Therapy for Alzheimer's Disease
Claritytek
NCT05788848
At-Home Telehealth Yoga for Treating Chronic Pain in People With Alzheimer's Disease and Their Caregiver's
Palo Alto Veterans Institute for Research
NCT04512040
Socially Isolated Older Adults Living With Dementia
University of Washington
NCT03666624
Drug-Drug Interaction (DDI) w/Ketoconazole or Fluconazole
Bristol-Myers Squibb
NCT00860275
The Cognitive Resilience Study
Duke University
NCT03016702
Developing Advanced Blood-Brain Barrier Permeability Imaging for Early AD
NYU Langone Health
NCT03389698
Evaluation of 123-I Iodobenzovesamicol (IBVM) and SPECT Imaging of Healthy Subjects and Patients With Alzheimer Disease
Institute for Neurodegenerative Disorders
NCT00480701
Movement Intervention for Memory Enhancement
Albert Einstein College of Medicine
NCT03475316
Allopregnanolone for Mild Cognitive Impairment Due to Alzheimer's Disease or Mild AD
University of Southern California
NCT02221622
Brain Vascular and Neurocognitive Health
The University of Texas at Arlington
NCT06497413
A Safety Study of PTI-125 in Healthy Volunteers
Pain Therapeutics
NCT03784300
Multiple Dose Study Evaluating the Safety and Tolerability of NSA-789
Wyeth is now a wholly owned subsidiary of Pfizer
NCT00795730
Transcranial Magnetic Stimulation and Constraint Induced Language Therapy for Alzheimer Disease
University of Pennsylvania
NCT04482179
Evaluation of [123I] AV51 and SPECT as a Marker of Beta-amyloid Protein Deposition in Subjects With Alzheimer Disease in Comparison to Healthy Subjects
Institute for Neurodegenerative Disorders
NCT00556660
A Study of Two Doses of 18F-AV-45 in Alzheimer's Disease and Healthy Volunteers
Avid Radiopharmaceuticals
NCT01565330
Zolpidem CR and Hospitalized Patients With Dementia
Massachusetts General Hospital
NCT00814502
Improving Sleep and Cognition in Alzheimer's Disease
Emory University
NCT05200208
Rhythmically Entrained Exercise in Community-Dwelling Older Adults
University of North Carolina, Greensboro
NCT05462977
Neurodegenerative Alzheimer's Disease and Amyotrophic Lateral Sclerosis (NADALS) Basket Trial
Massachusetts General Hospital
NCT05189106
In-Home Technology for Caregivers of People With Dementia and Mild Cognitive Impairment: Rural Homes
University of California, Berkeley
NCT05159583
A Trial to Evaluate the Effects of BCG in Adults With MCI and Mild-to-Moderate AD
Steven E Arnold, MD
NCT05004688
A Phase 1 Study To Evaluate The Effect Of Dimebon On The Pharmacokinetics Of Dextromethorphan
Pfizer
NCT00788047
Our Care Wishes - Dementia
University of Pennsylvania
NCT05033262
Magnetic Resonance Spectroscopy Study of Memantine in Alzheimer's Disease
Northwell Health
NCT00551161
Network Modulation in Alzheimer's Disease
Brigham and Women's Hospital
NCT04045990
Treatment of Language and Memory in Patients With Alzheimer's Disease
University of Arkansas
NCT00593372
Low-Dose Opiate Therapy for Discomfort in Dementia (L-DOT)
VA Office of Research and Development
NCT00385684
Phase 1 Evaluation of [18F]MK-6240 PET as an Imaging Marker for Tau Protein
Invicro
NCT03071224
Cognition, Age, and RaPamycin Effectiveness - DownregulatIon of thE mTor Pathway
The University of Texas Health Science Center at San Antonio
NCT04200911
Imaging Inflammation in Alzheimer's Disease With 11C-ER176
Columbia University
NCT03744312
A Study to Assess Safety and Target Engagement of E2814 in Participants With Mild to Moderate Cognitive Impairment Due to Dominantly Inherited Alzheimer's Disease
Eisai
NCT04971733
Safety and Efficacy of Transcranial Electromagnetic Treatment Against Alzheimer's Disease
NeuroEM Therapeutics
NCT02958930
Alzheimer's Disease Stem Cells Multiple Infusions
Bernard (Barry) Baumel
NCT04040348
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 53 |
| Phase 2 | 51 |
| Phase 3 | 18 |
| Phase 4 | 8 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Alzheimer Disease Trial Landscape
312 indexed Alzheimer Disease studies · 155 recruiting (50%).
Phase mix: 26 late (III/IV) vs 104 early (I/II).
Top sponsor: Eli Lilly and Company (13 trials), 9 others listed. 50 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Alzheimer Disease?
PlainTrial tracks 312 US clinical trials for Alzheimer Disease, of which 155 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Alzheimer Disease?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.