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ACTIVE NOT RECRUITING Phase 2

A Study of JNJ-63733657 in Participants With Early Alzheimer's Disease

NCT04619420 · View on ClinicalTrials.gov ↗

Study Summary

The primary purpose of this study is to evaluate the effect of JNJ-63733657 versus placebo on clinical decline as measured by the Integrated Alzheimer's Disease Rating Scale (iADRS), a composite of cognition and function.

Interventions

  • DRUG Placebo
  • DRUG JNJ-63733657

Study Locations (20)

Florida

  • JEM Research LLC — Atlantis
  • Brain Matters Research — Delray Beach
  • Neuropsychiatric Research Center of SWFL — Fort Myers
  • Clinical NeuroScience Solutions Inc — Jacksonville
  • Alphab Global Research — Jupiter
  • K2 Medical Research — Maitland
  • Tandem Intermediate LLC — Maitland
  • Merritt Island Medical Research, LLC — Merritt Island
  • University of Miami Miller School of Medicine — Miami
  • Miami Jewish Health System — Miami

California

  • Irvine Clinical Research — Irvine
  • University of California San Diego Medical Center — La Jolla
  • University of California - Los Angeles — Los Angeles
  • Stanford University Medical Center — Palo Alto
  • Pacific Research Network Prn — San Diego
  • Syrentis Clinical Research — Santa Ana

Alabama

  • University of Alabama Birmingham — Birmingham

Arizona

  • Dignity Health — Phoenix

Connecticut

  • Yale University School Of Medicine — New Haven

District of Columbia

  • Georgetown University Clinical Research Unit CRU — Washington D.C.

Trial Details

FieldValue
Enrollment Target 523 participants
Start Date 2021-01-06
Est. Completion 2026-03-08
Phase Phase 2

Sponsor

Janssen Research & Development

442 total trials

Interested in This Trial?

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT04619420

The ClinicalTrials.gov registry entry for NCT04619420 describes a study currently listed as active not recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 523 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Janssen Research & Development, which has 442 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 3 conditions, with Alzheimer Disease appearing as the primary indexed condition, and to 2 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT04619420 reports 20 study locations spanning 6 distinct geographic areas — top geographies include Florida, California, Alabama. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT04619420 about?

NCT04619420 is a clinical study titled "A Study of JNJ-63733657 in Participants With Early Alzheimer's Disease". The primary purpose of this study is to evaluate the effect of JNJ-63733657 versus placebo on clinical decline as measured by the Integrated Alzheimer's Disease Rating Scale (iADRS), a composite of cognition and function.

What is the current status of trial NCT04619420?

This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 523 participants. The study started on 2021-01-06. Estimated completion is 2026-03-08.

What conditions does trial NCT04619420 study?

This clinical trial studies the following conditions: Alzheimer Disease, Dementia, Cognitive Dysfunction. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT04619420?

The interventions under investigation include: Placebo (DRUG), JNJ-63733657 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT04619420?

This trial is sponsored by Janssen Research & Development, which has 442 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT04619420 being conducted?

This trial has 20 study locations across Alabama, Arizona, California, Connecticut, District of Columbia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial