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NCT05361382 · ClinicalTrials.gov registry record · Phase 1
Head-to-Head Harmonization of Tau Tracers in Alzheimer's Disease
A Phase 1 study of Alzheimer Disease, sponsored by Tharick Pascoal.
- Active
- Registry status
- Phase 1
- Development phase
- 822
- Enrollment target
- 9
- Study locations
NCT05361382: Active Phase 1 study of Alzheimer Disease, sponsored by Tharick Pascoal.
NCT05361382 is a Phase 1 study of Alzheimer Disease that is active but no longer recruiting, run by Tharick Pascoal. The registered enrollment target is 822 participants, below the 2,748-participant average among 306 other Alzheimer Disease trials with a reported enrollment target (70% lower). The trial reports 9 study locations across 8 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05361382, a Phase 1 study of Alzheimer Disease, is active but no longer recruiting, sponsored by Tharick Pascoal.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 1
- Development phase
- 822 participants
- Enrollment target
- 9
- Study locations
Study Summary
The purpose of this study is to compare/harmonize cross-sectional and longitudinal tau tangle measurements obtained with the tau PET radiopharmaceuticals Flortaucipir and MK-6240 to elucidate the advantages and caveats of their use in clinical trials/practice and provide parameters to integrate their estimates.
Primary Outcome
Compare/harmonize cross-sectional tau deposition measurements (standardized uptake value ratio (SUVR)) obtained with Flortaupicir and MK-6240.
Conditions Studied
Interventions
- DRUG 18F-Flortaucipir radiopharmaceutical
- DRUG 18F-MK-6240 radiopharmaceutical
- DRUG Amyloid-β radiopharmaceutical (11C-PiB or 18F-Florbetaben or 18F-NAV-4694 or 18F-Flutemetamol)
Study Locations (9)
California
- Lawrence Berkeley National Laboratory - Berkeley
- University of California San Francisco - San Francisco
Minnesota
- Mayo Clinic - Rochester
Missouri
- Washington University in St. Louis - St Louis
Pennsylvania
- University of Pittsburgh - Pittsburgh
Rhode Island
- Brown University - Providence
Texas
- Houston Methodist Neurological Institute - Houston
Quebec
- McGill University - Montreal
Spain
- Sant Pau Biomedical Research Institute - Barcelona
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 822 participants |
| Start Date | 2022-03-02 |
| Est. Completion | 2027-05-31 |
| Phase | Phase 1 |
What the registry record for NCT05361382 still lists
NCT05361382 is an interventional study that assigns participants to a tested intervention. The registered 822 participants enrollment target is mid-sized for trials with a published cap, below the 2,748-participant average among 306 other Alzheimer Disease trials with a reported enrollment target (70% lower).
The record links to 1 condition, with Alzheimer Disease appearing as the primary indexed condition, and to 3 interventions - of which 18F-Flortaucipir radiopharmaceutical is the first listed.
NCT05361382 lists 9 locations in 8 states (California, Minnesota, Missouri).
Frequently Asked Questions
What is clinical trial NCT05361382 about?
NCT05361382 is a clinical study titled "Head-to-Head Harmonization of Tau Tracers in Alzheimer's Disease". The purpose of this study is to compare/harmonize cross-sectional and longitudinal tau tangle measurements obtained with the tau PET radiopharmaceuticals Flortaucipir and MK-6240 to elucidate the advantages and caveats of their use in clinical trials/practice and provide parameters to integrate thei...
What is the current status of trial NCT05361382?
This trial is currently active not recruiting. It is a Phase 1 study. The enrollment target is 822 participants. The study started on 2022-03-02. Estimated completion is 2027-05-31.
What conditions does trial NCT05361382 study?
This clinical trial studies the following conditions: Alzheimer Disease.
What interventions are being tested in trial NCT05361382?
The interventions under investigation include: 18F-Flortaucipir radiopharmaceutical (DRUG), 18F-MK-6240 radiopharmaceutical (DRUG), Amyloid-β radiopharmaceutical (11C-PiB or 18F-Florbetaben or 18F-NAV-4694 or 18F-Flutemetamol) (DRUG).
Who is sponsoring clinical trial NCT05361382?
This trial is sponsored by Tharick Pascoal, which has 1 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT05361382 being conducted?
This trial has 9 study locations across California, Minnesota, Missouri, Pennsylvania, Rhode Island. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT05361382's enrollment target sits among peer trials
822 37th of 306 higher than 270 of 306 other Alzheimer Disease trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Alzheimer Disease trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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