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NCT04517552 · ClinicalTrials.gov registry record
Investigation of Inflammation Using [C-11]-CS1P1
A clinical trial of Alzheimer Disease, sponsored by Tammie L. S. Benzinger, MD, PhD.
- Active
- Registry status
- 60
- Enrollment target
- 1
- Study location
NCT04517552: Active study of Alzheimer Disease, sponsored by Tammie L. S. Benzinger, MD, PhD.
NCT04517552 is a study of Alzheimer Disease that is active but no longer recruiting, run by Tammie L. S. Benzinger, MD, PhD. The registered enrollment target is 60 participants, below the 2,751-participant average among 306 other Alzheimer Disease trials with a reported enrollment target (98% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT04517552, a study of Alzheimer Disease, is active but no longer recruiting, sponsored by Tammie L. S. Benzinger, MD, PhD.
- ACTIVE NOT RECRUITING
- Registry status
- 60 participants
- Enrollment target
- 1
- Study location
Study Summary
There is a compelling need for a noninvasive imaging approach to measure S1P1 in both preclinical models of diseases and humans. PET measures of S1P1 expression is critical for elucidating the pathophysiological roles of S1P1 in neuroinflammation and neurodegeneration. The relevance of S1P1 in clinical disease has become readily apparent with the FDA approval of the S1P1 modulator FTY720 (fingolimod) for treating relapsing-remitting MS (RR-MS). MS is a chronic autoimmune, inflammatory disease caused by lymphocytic infiltration that leads to demyelinating neurodegenerative disease.
Primary Outcome
Whole-body PET/CT images (skull vertex to proximal thighs) will be obtained in 10 healthy volunteers (5 males and 5 females) for up to a maximum of 4 hours immediately following intravenous (IV) injection of 12-17 mCi of \[11C\]-CS1P1 (dosage range calculated from rodent dosimetry data extrapolated to humans).
Conditions Studied
Interventions
- DRUG [11C]-CS1P1
Study Locations (1)
Missouri
- Washington University School of Medicine - St Louis
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 60 participants |
| Start Date | 2020-11-02 |
| Est. Completion | 2026-07-08 |
What the registry record for NCT04517552 still lists
NCT04517552 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 60 participants, a relatively small participant target, below the 2,751-participant average among 306 other Alzheimer Disease trials with a reported enrollment target (98% lower).
The record links to 1 condition, with Alzheimer Disease appearing as the primary indexed condition, and to 1 intervention - of which [11C]-CS1P1 is the first listed.
NCT04517552 reports a single indexed study location in Missouri.
Frequently Asked Questions
What is clinical trial NCT04517552 about?
NCT04517552 is a clinical study titled "Investigation of Inflammation Using [C-11]-CS1P1". There is a compelling need for a noninvasive imaging approach to measure S1P1 in both preclinical models of diseases and humans. PET measures of S1P1 expression is critical for elucidating the pathophysiological roles of S1P1 in neuroinflammation and neurodegeneration. The relevance of S1P1 in clini...
What is the current status of trial NCT04517552?
This trial is currently active not recruiting. The enrollment target is 60 participants. The study started on 2020-11-02. Estimated completion is 2026-07-08.
What conditions does trial NCT04517552 study?
This clinical trial studies the following conditions: Alzheimer Disease.
What interventions are being tested in trial NCT04517552?
The interventions under investigation include: [11C]-CS1P1 (DRUG).
Who is sponsoring clinical trial NCT04517552?
This trial is sponsored by Tammie L. S. Benzinger, MD, PhD, which has 8 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT04517552 being conducted?
This trial has 1 study location across Missouri. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Alzheimer Disease
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT04517552's enrollment target sits among peer trials
60 187th of 306 higher than 108 of 306 other Alzheimer Disease trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Alzheimer Disease trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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