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A Study of ONO-2020 in Participants With Mild to Moderate Alzheimer's Disease
NCT06881836 · View on ClinicalTrials.gov ↗
Study Summary
This is a Phase 2, double-blind, parallel-group, placebo-controlled study to assess safety, tolerability, pharmacokinetics, and efficacy of ONO-2020 in participants with mild to moderate Alzheimer's disease (AD). This study aims to determine whether administering ONO-2020, an epigenetic regulator, may improve cognitive functions like memory and cognition in individuals with Alzheimer's disease dementia.
Conditions Studied
Interventions
- DRUG Placebo
- DRUG ONO-2020
Study Locations (20)
Florida
- Brain Matters Research — Delray Beach
- Velocity Clinical Research, Hallandale Beach — Hallandale
- Premier Clinical Research Institute; Inc. — Miami
- Quantum Clinical Trials — Miami Beach
- Suncoast Clinical Research — New Port Richey
- Renstar Medical Research — Ocala
- Charter Research - Orlando — Orlando
- Accel Research Sites - Brain and Spine Institute — Port Orange
- USF Health Byrd Alzheimer's Institute — Tampa
- ForCare Clinical Research — Tampa
Arizona
- Banner Alzheimer's Institute (BAI) — Phoenix
- Clinical Endpoints — Scottsdale
- Banner Sun Health Research Institute — Sun City
- Center for Neurosciences-Research — Tucson
California
- Profound Research LLC at The Neurology Center of Southern California — Carlsbad
- Neurology Center of North Orange County — Fullerton
- Stanford University — Palo Alto
- Sunwise Clinical Research — Walnut Creek
Alabama
- University of Alabama at Birmingham — Birmingham
Colorado
- CenExel Rocky Mountain Clinical Research — Englewood
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 240 participants |
| Start Date | 2025-04-24 |
| Est. Completion | 2026-08 |
| Phase | Phase 2 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06881836
The ClinicalTrials.gov registry entry for NCT06881836 describes a study currently listed as active not recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 240 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Ono Pharmaceutical Co., which has 37 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Alzheimer Disease appearing as the primary indexed condition, and to 2 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT06881836 reports 20 study locations spanning 5 distinct geographic areas — top geographies include Florida, Arizona, California. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT06881836 about?
NCT06881836 is a clinical study titled "A Study of ONO-2020 in Participants With Mild to Moderate Alzheimer's Disease". This is a Phase 2, double-blind, parallel-group, placebo-controlled study to assess safety, tolerability, pharmacokinetics, and efficacy of ONO-2020 in participants with mild to moderate Alzheimer's disease (AD). This study aims to determine whether administering ONO-2020, an epigenetic regulator, m...
What is the current status of trial NCT06881836?
This trial is currently active not recruiting. It is a Phase 2 study. The enrollment target is 240 participants. The study started on 2025-04-24. Estimated completion is 2026-08.
What conditions does trial NCT06881836 study?
This clinical trial studies the following conditions: Alzheimer Disease. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT06881836?
The interventions under investigation include: Placebo (DRUG), ONO-2020 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT06881836?
This trial is sponsored by Ono Pharmaceutical Co., which has 37 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT06881836 being conducted?
This trial has 20 study locations across Alabama, Arizona, California, Colorado, Florida. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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