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ClinicalTrials.gov 159 recruiting now official registry

Acute Myeloid Leukemia clinical trials

159 of 307 indexed Acute Myeloid Leukemia trials are currently recruiting.

307 US clinical trials · 159 currently recruiting

Acute Myeloid Leukemia is the subject of 307 registered US clinical trials on ClinicalTrials.gov, 159 of them currently open to new participants. 13 are in Phase 3-4 (later-stage) and 265 in Phase 1-2 (earlier-stage). The most active sponsor is M.D. Anderson Cancer Center, running 38 of these trials.

The research picture

Acute Myeloid Leukemia has 307 registered US clinical trials, 159 of them open to new participants right now, about 52% of the total.

159
recruiting participants now
52%
of trials open to enrollment
13
in Phase 3–4 (later-stage)
38
top sponsor: M.D. Anderson Cancer Center
Phase 1160Phase 2105Phase 312Phase 41

Active & Recent Trials

307 total, page 4 of 7

RECRUITING Phase 1 15 participants

A Study of CD371-YSNVZIL-18 CAR T Cells in People With Acute Myeloid Leukemia

Memorial Sloan Kettering Cancer Center

NCT06017258

RECRUITING Phase 1 15 participants

Olutasidenib Single Plus Combo Therapy in IDH1mut AML After Induction and Consolidation

Virginia Commonwealth University

NCT07130695

RECRUITING Phase 1 15 participants

225Ac-DOTA-Anti-CD38 Daratumumab Monoclonal Antibody With Fludarabine, Melphalan and Total Marrow and Lymphoid Irradiation as Conditioning Treatment for Donor Stem Cell Transplant in Patients With High-Risk Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia and Myelodysplastic Syndrome

City of Hope Medical Center

NCT06287944

RECRUITING Phase 1 15 participants

Olutasidenib for the Treatment of Patients With IDH1 Mutated AML, MDS or CMML After Donor Hematopoietic Cell Transplant

City of Hope Medical Center

NCT06543381

RECRUITING Phase 1 15 participants

Preemptive CIML NK Cell Therapy After Hematopoietic Stem Cell Transplantation

Dana-Farber Cancer Institute

NCT06138587

RECRUITING Phase 1 12 participants

A First-in-Human Study of HLA-Partially to Fully Matched Allogenic Cryopreserved Deceased Donor Bone Marrow Transplantation for Patients With Hematologic Malignancies

Ossium Health

NCT05589896

RECRUITING Phase 4 12 participants

Oral Azacitidine in Transplant-Eligible Patients With Acute Myeloid Leukemia (AML) Suffering From Health-Inequality

Virginia Commonwealth University

NCT06370000

RECRUITING Phase 1 10 participants

CIML NK Cells With Venetoclax for AML

Dana-Farber Cancer Institute

NCT06152809

RECRUITING Phase 1 8 participants

A Multi-Site Break Through Cancer Trial: Phase II Study Investigating Dual Inhibition of BCL2 and Menin in AML MRD Using the Combination of Venetoclax and Revumenib

M.D. Anderson Cancer Center

NCT06284486

ACTIVE NOT RECRUITING Phase 3 1,645 participants

Bortezomib and Sorafenib Tosylate in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia

National Cancer Institute (NCI)

NCT01371981

ACTIVE NOT RECRUITING Phase 3 435 participants

Mismatched Related Donor Versus Matched Unrelated Donor Stem Cell Transplantation for Children, Adolescents, and Young Adults With Acute Leukemia or Myelodysplastic Syndrome

Children's Oncology Group

NCT05457556

ACTIVE NOT RECRUITING 350 participants

Cardiovascular Reserve Evaluation in Survivors of Transplant, CREST Study

City of Hope Medical Center

NCT04537871

ACTIVE NOT RECRUITING NA 342 participants

A High Intensity Electronic Health Intervention for the Reduction of Learning Disparities in Childhood Cancer Survivors

City of Hope Medical Center

NCT05428176

ACTIVE NOT RECRUITING NA 320 participants

A Collaborative Palliative and Leukemia Care Model for Patients With AML and MDS Receiving Non-Intensive Therapy

Massachusetts General Hospital

NCT03310918

ACTIVE NOT RECRUITING Phase 2 313 participants

HLA-Mismatched Unrelated Donor Peripheral Blood Stem Cell Transplantation With Reduced Dose Post Transplantation Cyclophosphamide GvHD Prophylaxis

Center for International Blood and Marrow Transplant Research

NCT06001385

ACTIVE NOT RECRUITING 307 participants

Assessment of Chimerism and Relapse Post Bone Marrow/Hematopoietic Cell Transplant (HCT) Using AlloHeme Test

CareDx

NCT04635384

ACTIVE NOT RECRUITING Phase 3 280 participants

Response-Based Chemotherapy in Treating Newly Diagnosed Acute Myeloid Leukemia or Myelodysplastic Syndrome in Younger Patients With Down Syndrome

Children's Oncology Group

NCT02521493

ACTIVE NOT RECRUITING Phase 2 267 participants

Daunorubicin and Cytarabine With or Without Uproleselan in Treating Older Adult Patients With Acute Myeloid Leukemia Receiving Intensive Induction Chemotherapy

National Cancer Institute (NCI)

NCT03701308

ACTIVE NOT RECRUITING Phase 1 255 participants

Precision-T: A Study of Orca-T in Recipients Undergoing Allogeneic Transplantation for Hematologic Malignancies

Orca Biosystems

NCT04013685

ACTIVE NOT RECRUITING Phase 1 218 participants

IMGN632 as Monotherapy or With Venetoclax and/or Azacitidine for Participants With CD123-Positive Acute Myeloid Leukemia

AbbVie

NCT04086264

ACTIVE NOT RECRUITING NA 214 participants

High-Intensity Parent Intervention Program in Improving Learning and School Functioning in Latino Children With Acute Leukemia or Lymphoblastic Lymphoma

City of Hope Medical Center

NCT03178617

ACTIVE NOT RECRUITING Phase 2 206 participants

A Trial of Epigenetic Priming in Patients With Newly Diagnosed Acute Myeloid Leukemia

St. Jude Children's Research Hospital

NCT03164057

ACTIVE NOT RECRUITING 206 participants

Quality of Life Model for Older Patients With AML

H. Lee Moffitt Cancer Center and Research Institute

NCT04380441

ACTIVE NOT RECRUITING Phase 3 187 participants

Precision-T: A Randomized Study of Orca-T in Recipients Undergoing Allogeneic Transplantation for Hematologic Malignancies

Orca Biosystems

NCT05316701

ACTIVE NOT RECRUITING Phase 2 181 participants

Gilteritinib vs Midostaurin in FLT3 Mutated Acute Myeloid Leukemia

PrECOG

NCT03836209

ACTIVE NOT RECRUITING Phase 1 181 participants

A Study to Assess Safety, Tolerability and Preliminary Efficacy of Bexmarilimab in Combination With Standard of Care in Patients With Hematological Malignancies

Faron Pharmaceuticals

NCT05428969

ACTIVE NOT RECRUITING Phase 2 178 participants

Decitabine, Cytarabine, and Daunorubicin Hydrochloride in Treating Patients With Acute Myeloid Leukemia

National Cancer Institute (NCI)

NCT01627041

ACTIVE NOT RECRUITING Phase 3 165 participants

An Extension Study of Venetoclax for Subjects Who Have Completed a Prior Venetoclax Clinical Trial

AbbVie

NCT03844048

ACTIVE NOT RECRUITING Phase 3 153 participants

Study of Iomab-B vs. Conventional Care in Older Subjects With Active, Relapsed or Refractory Acute Myeloid Leukemia

Actinium Pharmaceuticals

NCT02665065

ACTIVE NOT RECRUITING Phase 2 133 participants

Azacitidine and Gemtuzumab Ozogamicin in Treating Older Patients With Previously Untreated Acute Myeloid Leukemia

National Cancer Institute (NCI)

NCT00658814

ACTIVE NOT RECRUITING Phase 3 127 participants

Galinpepimut-S Versus Investigator's Choice of Best Available Therapy for Maintenance in AML CR2/CRp2

Sellas Life Sciences Group

NCT04229979

ACTIVE NOT RECRUITING Phase 2 116 participants

Venetoclax and Sequential Busulfan, Cladribine, and Fludarabine Phosphate Before Donor Stem Cell Transplant in Treating Patients With Acute Myelogenous Leukemia or Myelodysplastic Syndrome

M.D. Anderson Cancer Center

NCT02250937

ACTIVE NOT RECRUITING Phase 2 107 participants

Improving Risk Assessment of AML With a Precision Genomic Strategy to Assess Mutation Clearance

Washington University School of Medicine

NCT02756962

ACTIVE NOT RECRUITING Phase 1 101 participants

Pharmacokinetics, Safety, and Efficacy of ASTX727 in Combination With Venetoclax in Acute Myeloid Leukemia (AML)

Taiho Oncology

NCT04657081

ACTIVE NOT RECRUITING Phase 2 100 participants

Venetoclax and Azacitidine for the Treatment of Acute Myeloid Leukemia in the Post-Transplant Setting

M.D. Anderson Cancer Center

NCT04128501

ACTIVE NOT RECRUITING 100 participants

Acquired Pyruvate Kinase Deficiency In Clonal Myeloid Neoplasms

Massachusetts General Hospital

NCT04902833

ACTIVE NOT RECRUITING Phase 1 88 participants

PRGN-3006 Adoptive Cellular Therapy for CD33-Positive Relapsed or Refractory AML, MRD Positive AML or Higher Risk MDS

Precigen

NCT03927261

ACTIVE NOT RECRUITING Phase 2 87 participants

FLT PET/CT in Measuring Response in Patients With Previously Untreated Acute Myeloid Leukemia

National Cancer Institute (NCI)

NCT02392429

ACTIVE NOT RECRUITING Phase 2 85 participants

Venetoclax and ASTX727 for the Treatment of Relapsed, Refractory, or Newly Diagnosed Acute Myeloid Leukemia

M.D. Anderson Cancer Center

NCT04746235

ACTIVE NOT RECRUITING Phase 2 82 participants

Testing Nivolumab to Prevent Disease From Coming Back After Treatment in Patients With Acute Myeloid Leukemia, REMAIN Trial

National Cancer Institute (NCI)

NCT02275533

ACTIVE NOT RECRUITING 80 participants

AML/MDS Drug Sensitization by in Vivo Chemotherapy Administration

Washington University School of Medicine

NCT04263181

ACTIVE NOT RECRUITING Phase 1 77 participants

PET/MRI, 18F-FDG PET/CT and Whole Body MRI in Finding Extramedullary Myeloid Leukemia in Patients With Newly Diagnosed Acute Myeloid Leukemia

M.D. Anderson Cancer Center

NCT02390635

ACTIVE NOT RECRUITING Phase 1 72 participants

A Study of CFI-400945 With or Without Azacitidine in Patients With AML, MDS or CMML

Treadwell Therapeutics

NCT04730258

ACTIVE NOT RECRUITING Phase 1 65 participants

Safety and Efficacy of Quizartinib in Children and Young Adults With Acute Myeloid Leukemia (AML), a Cancer of the Blood

Daiichi Sankyo

NCT03793478

ACTIVE NOT RECRUITING Phase 2 64 participants

Ruxolitinib + Allogeneic Stem Cell Transplantation in AML

Massachusetts General Hospital

NCT03286530

ACTIVE NOT RECRUITING Phase 2 60 participants

CPX-351 or CLAG-M Regimen for the Treatment of Acute Myeloid Leukemia or Other High-Grade Myeloid Neoplasms in Medically Less-Fit Patients

Fred Hutchinson Cancer Center

NCT04195945

ACTIVE NOT RECRUITING Phase 2 60 participants

Cytokine Induced Memory-like NK Cell Adoptive Therapy After Haploidentical Donor Hematopoietic Cell Transplantation

Washington University School of Medicine

NCT02782546

ACTIVE NOT RECRUITING Phase 2 60 participants

BLAST MRD AML-2: BLockade of PD-1 Added to Standard Therapy to Target Measurable Residual Disease in Acute Myeloid Leukemia 2- A Randomized Phase 2 Study of Anti-PD-1 Pembrolizumab in Combination With Azacitidine and Venetoclax as Frontline Therapy in Unfit Patients With Acute Myeloid Leukemia

National Cancer Institute (NCI)

NCT04284787

ACTIVE NOT RECRUITING Phase 1 58 participants

Testing a New Chemotherapy Drug, KRT-232 (AMG-232) in Combination With Decitabine and Venetoclax in Patients With Acute Myeloid Leukemia

National Cancer Institute (NCI)

NCT03041688

ACTIVE NOT RECRUITING Phase 2 52 participants

A Trial to Evaluate Two Schedules of MS275 in Combination With 5AC in Elderly Patients With Acute Myeloid Leukemia (AML)

Hetty Carraway

NCT01305499

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Phase Distribution

PhaseTrial count
Phase 1 160
Phase 2 105
Phase 3 12
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Acute Myeloid Leukemia Trial Landscape

307 indexed Acute Myeloid Leukemia studies · 159 recruiting (52%).

Phase mix: 13 late (III/IV) vs 265 early (I/II).

Top sponsor: M.D. Anderson Cancer Center (38 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Acute Myeloid Leukemia?

PlainTrial tracks 307 US clinical trials for Acute Myeloid Leukemia, of which 159 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Acute Myeloid Leukemia?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.