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ClinicalTrials.gov 159 recruiting now official registry

Acute Myeloid Leukemia clinical trials

159 of 307 indexed Acute Myeloid Leukemia trials are currently recruiting.

307 US clinical trials · 159 currently recruiting

Acute Myeloid Leukemia is the subject of 307 registered US clinical trials on ClinicalTrials.gov, 159 of them currently open to new participants. 13 are in Phase 3-4 (later-stage) and 265 in Phase 1-2 (earlier-stage). The most active sponsor is M.D. Anderson Cancer Center, running 38 of these trials.

The research picture

Acute Myeloid Leukemia has 307 registered US clinical trials, 159 of them open to new participants right now, about 52% of the total.

159
recruiting participants now
52%
of trials open to enrollment
13
in Phase 3–4 (later-stage)
38
top sponsor: M.D. Anderson Cancer Center
Phase 1160Phase 2105Phase 312Phase 41

Active & Recent Trials

307 total, page 3 of 7

RECRUITING Phase 2 36 participants

Fractionated Gemtuzumab Ozogamicin in Treating Measurable Residual Disease in Patients With Acute Myeloid Leukemia

University of Washington

NCT03737955

RECRUITING Early Phase 1 36 participants

UPDATE AML: UPdated Disease Monitoring And Treatment for Enhanced Outcomes for Pediatric AML

Joanna Yi

NCT07059975

RECRUITING Phase 1 36 participants

Study of VIP943 in Subjects With Advanced CD123+ Hematologic Malignancies

Vincerx Pharma

NCT06034275

RECRUITING Phase 2 35 participants

Enasidenib (AG-221) Maintenance Post Allogeneic HCT in Patients With IDH2 Mutation

City of Hope Medical Center

NCT03728335

RECRUITING Phase 2 35 participants

Vedolizumab Plus Post-transplant Cyclophosphamide and Short Course Tacrolimus for the Prevention of Graft Versus Host Disease in Patients Undergoing Allogeneic Hematopoietic Cell Transplantation After Reduced Intensity Conditioning

City of Hope Medical Center

NCT06815003

RECRUITING Phase 1 34 participants

Study of Talazoparib in Combination With Chemotherapy in Relapsed Pediatric AML to Determine Safety and Efficacy

Norman J. Lacayo

NCT05101551

RECRUITING Phase 1 33 participants

FHD-286 With Low-Dose Weekly Decitabine/Venetoclax in Patients With Acute Myeloid Leukemia

Montefiore Medical Center

NCT07283094

RECRUITING Phase 1 33 participants

Orca-T Following Chemotherapy and Total Marrow and Lymphoid Irradiation for the Treatment of Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia or Myelodysplastic Syndrome

City of Hope Medical Center

NCT06195891

RECRUITING Phase 1 32 participants

Phase I Study of Q702 With Azacitidine and Venetoclax for Relapsed or Refractory Acute Myeloid Leukemia

M.D. Anderson Cancer Center

NCT06445907

RECRUITING Phase 1 32 participants

Pemigatinib After Chemotherapy for the Treatment of Newly Diagnosed Acute Myeloid Leukemia

OHSU Knight Cancer Institute

NCT04659616

RECRUITING Phase 1 32 participants

Phase I/II Clinical Trial of Proteasome Inhibitor in Combination With CPX-351 for the Treatment of Newly-Diagnosed TP53-mutated Acute Myeloid Leukemia (AML)

Masonic Cancer Center, University of Minnesota

NCT07008638

RECRUITING Phase 1 32 participants

A Phase Ib Trial of Azacitidine, Venetoclax and Allogeneic NK Cells for Acute Myeloid Leukemia (ADVENT-AML)

M.D. Anderson Cancer Center

NCT05834244

RECRUITING Phase 1 30 participants

8-Chloroadenosine in Combination With Venetoclax for the Treatment of Patients With Relapsed/Refractory Acute Myeloid Leukemia

City of Hope Medical Center

NCT05263284

RECRUITING Phase 1 30 participants

Chimeric Antigen Receptor T Cell Redirected to Target CD4 Positive Relapsed Refractory Acute Myeloid Leukemia (AML ) as a Bridge to Allogeneic Stem Cell Transplant

Huda Salman

NCT06197672

RECRUITING Phase 1 30 participants

Combination Chemotherapy (FLAG-Ida) With Pivekimab Sunirine (PVEK [IMGN632]) for the Treatment of Newly Diagnosed Adverse Risk Acute Myeloid Leukemia and Other High-Grade Myeloid Neoplasms

Fred Hutchinson Cancer Center

NCT06034470

RECRUITING NA 30 participants

Home Blood Transfusions

Thomas Jefferson University

NCT07121140

RECRUITING Phase 1 29 participants

A Prospective Trial of Dalbavancin-Based Prophylaxis in Children and Adolescents With High-Risk Leukemia

St. Jude Children's Research Hospital

NCT06810583

RECRUITING Phase 2 28 participants

Olutasidenib With Azacitidine Followed by Olutasidenib Maintenance for the Treatment of IDH1-mutated Acute Myeloid Leukemia in Patients With Prior Treatment With Venetoclax Plus a Hypomethylating Agent

University of California, Davis

NCT07304011

RECRUITING Phase 1 27 participants

Study in Relapsed/Refractory Acute Myeloid Leukemia or Myelodysplastic Syndrome Patients to Determine the Recommended Dose of CYAD-02

Celyad Oncology

NCT04167696

RECRUITING Phase 1 27 participants

Study to Evaluate the Pharmacokinetics and Safety of Oral Decitabine and Cedazuridine in Cancer Patients With Hepatic Impairment

Taiho Oncology

NCT04953910

RECRUITING Phase 1 27 participants

Revumenib for the Treatment of Acute Leukemia in Patients Post-Allogeneic Stem Cell Transplant

City of Hope Medical Center

NCT06575296

RECRUITING Phase 1 27 participants

CD33-CAR T Cell Therapy for the Treatment of Recurrent or Refractory Acute Myeloid Leukemia

City of Hope Medical Center

NCT05672147

RECRUITING Phase 2 25 participants

Decitabine With Ruxolitinib, Fedratinib or Pacritinib for the Treatment of Accelerated/Blast Phase Myeloproliferative Neoplasms

University of Washington

NCT04282187

RECRUITING Phase 1 24 participants

BXCL701 Phase 1 R/R Acute Myeloid Leukemia or Myelodysplastic Syndrome

Eric Stephen Winer, MD

NCT05703542

RECRUITING Phase 1 24 participants

A Phase Ib Study of Rezatapopt in Combination With Azacitidine in Patients With TP53Y220C Mutant Myeloid Malignancies (Acute Myeloid Leukemia or Myelodysplastic Syndrome)

M.D. Anderson Cancer Center

NCT06616636

RECRUITING Early Phase 1 24 participants

Hyperbaric Oxygen Therapy and Allogeneic Peripheral Blood Stem Cell (PBSC) Transplant

Omar Aljitawi

NCT03964506

RECRUITING Phase 1 24 participants

Iadademstat in Combination With Azacitidine and Venetoclax in Treating Newly Diagnosed Acute Myeloid Leukemia

OHSU Knight Cancer Institute

NCT06357182

RECRUITING Phase 1 24 participants

Safety and Proof-of-Concept Study of RPT1G in Adults With Acute Myeloid Leukemia and High-Risk Myelodysplastic Syndromes

Remedy Plan

NCT07107126

RECRUITING Phase 1 24 participants

Phase I Trial for Patients w/ Advanced Hematologic Malignancies Undergoing Allogeneic HCT

Stanford University

NCT06551584

RECRUITING Phase 1 23 participants

Phase Ib Study of CD33 FPBMC in Patients With MRD+ AML or MDS

University of Virginia

NCT07270978

RECRUITING Phase 1 22 participants

Revumenib in Combination With 7+3 + Midostaurin in AML

Richard Stone, MD

NCT06313437

RECRUITING Phase 1 22 participants

Alpha/Beta CD19+ Depleted Haploidentical Transplantation + Zometa for Pediatric Hematologic Malignancies and Solid Tumors

University of Wisconsin, Madison

NCT02508038

RECRUITING Phase 1 22 participants

Ziftomenib Maintenance Post Allo-HCT

Massachusetts General Hospital

NCT06440135

RECRUITING Phase 1 22 participants

A Phase I Study Investigating the Combination of the Menin Inhibitor Ziftomenib With Venetoclax and Gemtuzumab in Pediatric Patients With Acute Myeloid Leukemia

M.D. Anderson Cancer Center

NCT06448013

RECRUITING Phase 2 20 participants

Azacitidine or Decitabine With Venetoclax for Acute Myeloid Leukemia With Prior Hypomethylating Agent Failure

Brian Jonas

NCT04905810

RECRUITING 20 participants

Acute Myeloid Leukemia and Markers of Leukemia Stem Cells (CLL1 and CD45RA)

Suhu Liu

NCT06297551

RECRUITING Phase 1 20 participants

Decitabine and Venetoclax Treatment as Maintenance Therapy in Patients Post Allograft Stem Cell Transplant

Benjamin Tomlinson

NCT06129734

RECRUITING Phase 1 20 participants

Cytokine-Induced Memory-Like Natural Killer Cells (CIML-NK) for Relapsed & Refractory Acute Myeloid Leukemia (AML)

Children's Hospital Medical Center, Cincinnati

NCT05580601

RECRUITING Phase 1 20 participants

Trial of Novel Anti-leukemia Agents in Flu/Mel RIC Transplant for Myeloid Malignancies

University of Alabama at Birmingham

NCT07044544

RECRUITING Phase 2 20 participants

Combination Chemotherapy (FLAG-Ida) Followed Immediately by Reduced-Intensity Total Body Radiation Therapy and Donor Hematopoietic Cell Transplant for the Treatment of Adults Age 60 and Older With Newly Diagnosed Adverse-Risk Acute Myeloid Leukemia or Other High-Grade Myeloid Cancer

Fred Hutchinson Cancer Center

NCT07046078

RECRUITING Phase 2 20 participants

Cladribine Venetoclax in Monocytic AML

University of Colorado, Denver

NCT06232655

RECRUITING Phase 1 20 participants

Safety and Efficacy of Expanded, Universal Donor Natural Killer Cells for Relapsed/Refractory AML

Nationwide Children's Hospital

NCT05503134

RECRUITING Phase 2 20 participants

Alpha/Beta T Cell and CD19+ B Cell Depletion in Allogeneic Stem Cell Transplantation in Patients With Malignant Diseases

University of Florida

NCT05800210

RECRUITING Phase 1 18 participants

CPX-351 in Combination With Gemtuzumab Ozogamicin in Newly Diagnosed AML

H. Lee Moffitt Cancer Center and Research Institute

NCT05558124

RECRUITING Phase 1 18 participants

PLAT-08: A Study Of SC-DARIC33 CAR T Cells In Pediatric And Young Adults With Relapsed Or Refractory CD33+ AML

Seattle Children's Hospital

NCT05105152

RECRUITING Phase 1 18 participants

Phase I Study of HC-7366 for Acute Myeloid Leukemia

M.D. Anderson Cancer Center

NCT06285890

RECRUITING Phase 1 18 participants

CER-1236 in Patients With Acute Myeloid Leukemia (AML)

CERo Therapeutics Holdings

NCT06834282

RECRUITING Phase 1 18 participants

Venetoclax and Bomedemstat in Patients With Relapsed/Refractory Acute Myeloid Leukemia

Terrence J Bradley, MD

NCT05597306

RECRUITING Phase 1 18 participants

Study to Evaluate the Pharmacokinetics and Safety of Oral Decitabine and Cedazuridine in Cancer Patients With Renal Impairment

Taiho Oncology

NCT04953897

RECRUITING Phase 2 16 participants

Olutasidenib, Venetoclax, and Azacitidine in IDH1 Mutated Newly Diagnosed Acute Myeloid Leukemia Patients Eligible for Intensive Induction Chemotherapy

Justin Watts, MD

NCT06782542

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Phase Distribution

PhaseTrial count
Phase 1 160
Phase 2 105
Phase 3 12
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Acute Myeloid Leukemia Trial Landscape

307 indexed Acute Myeloid Leukemia studies · 159 recruiting (52%).

Phase mix: 13 late (III/IV) vs 265 early (I/II).

Top sponsor: M.D. Anderson Cancer Center (38 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Acute Myeloid Leukemia?

PlainTrial tracks 307 US clinical trials for Acute Myeloid Leukemia, of which 159 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Acute Myeloid Leukemia?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.