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ClinicalTrials.gov 159 recruiting now official registry

Acute Myeloid Leukemia clinical trials

159 of 307 indexed Acute Myeloid Leukemia trials are currently recruiting.

307 US clinical trials · 159 currently recruiting

Acute Myeloid Leukemia is the subject of 307 registered US clinical trials on ClinicalTrials.gov, 159 of them currently open to new participants. 13 are in Phase 3-4 (later-stage) and 265 in Phase 1-2 (earlier-stage). The most active sponsor is M.D. Anderson Cancer Center, running 38 of these trials.

The research picture

Acute Myeloid Leukemia has 307 registered US clinical trials, 159 of them open to new participants right now, about 52% of the total.

159
recruiting participants now
52%
of trials open to enrollment
13
in Phase 3–4 (later-stage)
38
top sponsor: M.D. Anderson Cancer Center
Phase 1160Phase 2105Phase 312Phase 41

Active & Recent Trials

307 total, page 5 of 7

ACTIVE NOT RECRUITING Phase 2 50 participants

Comparing the Addition of an Anti-Cancer Drug, Pomalidomide, to the Usual Chemotherapy Treatment (Daunorubicin and Cytarabine Liposome) in Newly Diagnosed Acute Myeloid Leukemia With Myelodysplastic Syndrome-Related Changes

National Cancer Institute (NCI)

NCT04802161

ACTIVE NOT RECRUITING Phase 2 50 participants

AZA + Venetoclax as Maintenance Therapy in Patients With AML in Remission

M.D. Anderson Cancer Center

NCT04062266

ACTIVE NOT RECRUITING Phase 1 50 participants

Venetoclax in Combination With Intensive Induction and Consolidation Chemotherapy in Treatment Naïve AML

Dana-Farber Cancer Institute

NCT03709758

ACTIVE NOT RECRUITING Phase 1 50 participants

A Pilot Trial of Atorvastatin in Tumor Protein 53 (p53) -Mutant and p53 Wild-Type Malignancies

Joaquina Baranda

NCT03560882

ACTIVE NOT RECRUITING Phase 2 49 participants

BLAST MRD AML-1: BLockade of PD-1 Added to Standard Therapy to Target Measurable Residual Disease in Acute Myeloid Leukemia 1- A Randomized Phase 2 Study of Anti-PD-1 Pembrolizumab in Combination With Intensive Chemotherapy as Frontline Therapy in Patients With Acute Myeloid Leukemia

National Cancer Institute (NCI)

NCT04214249

ACTIVE NOT RECRUITING Phase 2 48 participants

Cognitive Behavioral Therapy in Helping Patients With Acute Myeloid Leukemia or Lymphoma With Cancer-Related Fatigue

M.D. Anderson Cancer Center

NCT03747757

ACTIVE NOT RECRUITING Phase 1 44 participants

Administration of Donor Multi TAA-Specific T Cells for AML or MDS (ADSPAM)

Baylor College of Medicine

NCT02494167

ACTIVE NOT RECRUITING Phase 2 42 participants

Azacitidine and Venetoclax as Induction Therapy With Venetoclax Maintenance in the Elderly With AML

University of Colorado, Denver

NCT03466294

ACTIVE NOT RECRUITING Phase 1 40 participants

Azacitidine, Venetoclax, and Pevonedistat in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia

M.D. Anderson Cancer Center

NCT03862157

ACTIVE NOT RECRUITING Phase 1 40 participants

A Phase 1, Open-Label, Sequential Cross-over, Bioavailability/Bioequivalence Study to Compare the Pharmacokinetics of Oral Cladribine With the Reference Listed Drug, Intravenous Cladribine

M.D. Anderson Cancer Center

NCT06021600

ACTIVE NOT RECRUITING Phase 2 38 participants

Study of Intensity Modulated Total Marrow Irradiation (IM-TMI) in Addition to Fludarabine/Busulfan Conditioning for Allogeneic Transplantation in High Risk AML and Myelodysplastic Syndromes

University of Illinois at Chicago

NCT03121014

ACTIVE NOT RECRUITING Phase 1 36 participants

Tagraxofusp-erzs, an IL-3 Diphtheria Fusion Protein, in Combination With Gemtuzumab Ozogamicin in Patients With Relapsed/Refractory AML

Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

NCT05716009

ACTIVE NOT RECRUITING Phase 2 36 participants

Venetoclax and Azacitidine for Non-Elderly Adult Patients With Acute Myeloid Leukemia

University of Colorado, Denver

NCT03573024

ACTIVE NOT RECRUITING Phase 1 35 participants

A Phase 1 Study of BMF-500 in Adults With Acute Leukemia

Biomea Fusion

NCT05918692

ACTIVE NOT RECRUITING Phase 2 33 participants

Total Marrow and Lymphoid Irradiation as Conditioning Regimen Before Hematopoietic Cell Transplantation in Patients With Myelodysplastic Syndrome or Acute Leukemia

City of Hope Medical Center

NCT04262843

ACTIVE NOT RECRUITING Phase 1 31 participants

Genetically Modified T-cell Immunotherapy in Treating Patients With Relapsed/Refractory Acute Myeloid Leukemia and Persistent/Recurrent Blastic Plasmacytoid Dendritic Cell Neoplasm

City of Hope Medical Center

NCT02159495

ACTIVE NOT RECRUITING Phase 1 30 participants

Pevonedistat and Decitabine in Treating Patients With High Risk Acute Myeloid Leukemia

City of Hope Medical Center

NCT03009240

ACTIVE NOT RECRUITING NA 30 participants

Geriatric Optimization Plan to Improve Survival in Older Adult Allogeneic Hematopoietic Cell Transplant Candidates, OTIS Study

Ohio State University Comprehensive Cancer Center

NCT05972577

ACTIVE NOT RECRUITING Phase 1 29 participants

RAD001 in Combination With PKC412 in Patients With Relapsed, Refractory or Poor Prognosis AML or MDS

Richard Stone, MD

NCT00819546

ACTIVE NOT RECRUITING Phase 1 26 participants

Study of Venetoclax in Combination With Decitabine in Subjects With Acute Myeloid Leukemia

University of Chicago

NCT03844815

ACTIVE NOT RECRUITING Phase 2 25 participants

Topotecan Hydrochloride and Carboplatin With or Without Veliparib in Treating Advanced Myeloproliferative Disorders and Acute Myeloid Leukemia or Chronic Myelomonocytic Leukemia

National Cancer Institute (NCI)

NCT03289910

ACTIVE NOT RECRUITING Phase 1 25 participants

A Phase 1 Trial of CD25/Treg-depleted DLI Plus Ipilimumab for Myeloid Disease Relapse After Matched-HCT

Dana-Farber Cancer Institute

NCT03912064

ACTIVE NOT RECRUITING Phase 1 24 participants

Testing the Addition of an Anti-cancer Drug, Navtemadlin, to the Usual Treatments (Cytarabine and Idarubicin) in Patients With Acute Myeloid Leukemia

National Cancer Institute (NCI)

NCT04190550

ACTIVE NOT RECRUITING Phase 2 23 participants

Treosulfan-Based Versus Clofarabine-Based Conditioning Before Donor Hematopoietic Stem Cell Transplant for the Treatment of Myelodysplastic Syndromes or Acute Myeloid Leukemia

Fred Hutchinson Cancer Center

NCT04994808

ACTIVE NOT RECRUITING Phase 1 22 participants

NTX-301 in MDS/AML

University of Alabama at Birmingham

NCT04167917

ACTIVE NOT RECRUITING Phase 2 22 participants

Trial Evaluating MGTA-456 in Patients With High-Risk Malignancy

Masonic Cancer Center, University of Minnesota

NCT03674411

ACTIVE NOT RECRUITING Phase 3 21 participants

Haploidentical Allogeneic Peripheral Blood Transplantation: Examining Checkpoint Immune Regulators' Expression

Dartmouth-Hitchcock Medical Center

NCT03480360

ACTIVE NOT RECRUITING Phase 2 20 participants

Adding Itacitinib to Cyclophosphamide and Tacrolimus for the Prevention of Graft Versus Host Disease in Patients Undergoing Hematopoietic Stem Cell Transplants

City of Hope Medical Center

NCT05364762

ACTIVE NOT RECRUITING Phase 1 20 participants

Gamma Delta T-cell Infusion for AML at High Risk of Relapse After Allo HCT

H. Lee Moffitt Cancer Center and Research Institute

NCT05015426

ACTIVE NOT RECRUITING Phase 2 20 participants

Decitabine, Venetoclax, and Ponatinib for the Treatment of Philadelphia Chromosome-Positive Acute Myeloid Leukemia or Myeloid Blast Phase or Accelerated Phase Chronic Myelogenous Leukemia

M.D. Anderson Cancer Center

NCT04188405

ACTIVE NOT RECRUITING Phase 2 19 participants

A Study to Compare the Efficacy and Safety of Oral Azacitidine Plus Best Supportive Care Versus Best Supportive Care as Maintenance Therapy in Japanese Participants With Acute Myeloid Leukemia (AML) in Complete Remission

Bristol-Myers Squibb

NCT05197426

ACTIVE NOT RECRUITING Phase 1 18 participants

Chimeric Antigen Receptor T-cells for The Treatment of AML Expressing CLL-1 Antigen

Baylor College of Medicine

NCT04219163

ACTIVE NOT RECRUITING Phase 1 16 participants

Cytokine-Treated Veto Cells in Treating Patients With Hematologic Malignancies Following Stem Cell Transplant

M.D. Anderson Cancer Center

NCT03622788

ACTIVE NOT RECRUITING Phase 1 16 participants

Combination Navitoclax, Venetoclax and Decitabine for Advanced Myeloid Neoplasms

Jacqueline Garcia, MD

NCT05455294

ACTIVE NOT RECRUITING Phase 1 15 participants

Bortezomib, Sorafenib Tosylate, and Decitabine in Treating Patients With Acute Myeloid Leukemia

National Cancer Institute (NCI)

NCT01861314

ACTIVE NOT RECRUITING Phase 1 15 participants

Vorinostat Dose-escalation After Allogeneic Hematopoietic Cell Transplantation

Johns Hopkins All Children's Hospital

NCT03843528

ACTIVE NOT RECRUITING Phase 1 15 participants

Tomivosertib in Relapsed or Refractory Acute Myeloid Leukemia (AML)

Northwestern University

NCT05744739

ACTIVE NOT RECRUITING Phase 1 15 participants

Administration of Donor T Cells With the Caspase-9 Suicide Gene

Baylor College of Medicine

NCT01494103

ACTIVE NOT RECRUITING Phase 2 14 participants

Using the Anticancer Drug Olaparib to Treat Relapsed/Refractory Acute Myeloid Leukemia or Myelodysplastic Syndrome With an Isocitrate Dehydrogenase (IDH) Mutation

National Cancer Institute (NCI)

NCT03953898

ACTIVE NOT RECRUITING Phase 1 13 participants

Entrectinib in Combination With ASTX727 for the Treatment of Relapsed/Refractory TP53 Mutated Acute Myeloid Leukemia

OHSU Knight Cancer Institute

NCT05396859

ACTIVE NOT RECRUITING Phase 2 11 participants

Fractionated Gemtuzumab Ozogamicin Followed by Non-engraftment Donor Leukocyte Infusions for Relapsed/Refractory Acute Myeloid Leukemia

Brown University

NCT03374332

ACTIVE NOT RECRUITING Early Phase 1 10 participants

Anti-Leukemia Immune Responses After Irradiation of Extramedullary Tumors

M.D. Anderson Cancer Center

NCT05035706

ACTIVE NOT RECRUITING Phase 2 7 participants

Triplex Vaccine in Preventing CMV Infection in Patients Undergoing Hematopoietic Stem Cell Transplantation

City of Hope Medical Center

NCT04060277

ACTIVE NOT RECRUITING Phase 1 7 participants

90Y-DOTA-anti-CD25 Basiliximab, Fludarabine, Melphalan, and Total Marrow and Lymphoid Irradiation for the Treatment of High-Risk Acute Leukemia or Myelodysplastic Syndrome

City of Hope Medical Center

NCT05139004

ACTIVE NOT RECRUITING Phase 1 6 participants

2157GCCC:Phase 1 of Calaspargase Pegol-mknl W/ Cytarabine and Idarubicin in Newly Dx AML

West Virginia University

NCT04953780

ACTIVE NOT RECRUITING Phase 1 6 participants

Dose-Escalation and Dose-Expansion Study to Evaluate the Safety and Tolerability of Anti-CD7 Allogeneic CAR T-Cells (WU-CART-007) in Patients With CD7+ Hematologic Malignancies

Washington University School of Medicine

NCT05377827

ACTIVE NOT RECRUITING Phase 1 5 participants

Testing Oral Decitabine and Cedazuridine (ASTX727) in Combination With Venetoclax for Higher-Risk Acute Myeloid Leukemia Patients

National Cancer Institute (NCI)

NCT04817241

COMPLETED Phase 2 546 participants

Decitabine as Maintenance Therapy After Standard Therapy in Treating Patients With Previously Untreated Acute Myeloid Leukemia

National Cancer Institute (NCI)

NCT00416598

COMPLETED Phase 3 488 participants

Study of Vidaza Versus Conventional Care Regimens for the Treatment of Acute Myeloid Leukemia (AML)

Celgene

NCT01074047

COMPLETED Phase 2 293 participants

An Extension Study to Determine the Safety and Anti-Leukemic Effects of Imatinib Mesylate in Adult Participants With Ph+ Leukemia

Novartis Pharmaceuticals

NCT00171249

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Phase Distribution

PhaseTrial count
Phase 1 160
Phase 2 105
Phase 3 12
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Acute Myeloid Leukemia Trial Landscape

307 indexed Acute Myeloid Leukemia studies · 159 recruiting (52%).

Phase mix: 13 late (III/IV) vs 265 early (I/II).

Top sponsor: M.D. Anderson Cancer Center (38 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Acute Myeloid Leukemia?

PlainTrial tracks 307 US clinical trials for Acute Myeloid Leukemia, of which 159 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Acute Myeloid Leukemia?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.