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ClinicalTrials.gov 159 recruiting now official registry

Acute Myeloid Leukemia clinical trials

159 of 307 indexed Acute Myeloid Leukemia trials are currently recruiting.

307 US clinical trials · 159 currently recruiting

Acute Myeloid Leukemia is the subject of 307 registered US clinical trials on ClinicalTrials.gov, 159 of them currently open to new participants. 13 are in Phase 3-4 (later-stage) and 265 in Phase 1-2 (earlier-stage). The most active sponsor is M.D. Anderson Cancer Center, running 38 of these trials.

The research picture

Acute Myeloid Leukemia has 307 registered US clinical trials, 159 of them open to new participants right now, about 52% of the total.

159
recruiting participants now
52%
of trials open to enrollment
13
in Phase 3–4 (later-stage)
38
top sponsor: M.D. Anderson Cancer Center
Phase 1160Phase 2105Phase 312Phase 41

Active & Recent Trials

307 total, page 2 of 7

RECRUITING Phase 1 84 participants

Decitabine/Cedazuridine and Venetoclax in Combination With Ivosidenib or Enasidenib for the Treatment of Relapsed or Refractory Acute Myeloid Leukemia

M.D. Anderson Cancer Center

NCT04774393

RECRUITING Phase 2 83 participants

A Study of Tagraxofusp in Combination With Venetoclax and Azacitidine in Adults With Untreated CD123+ Acute Myeloid Leukemia Who Cannot Undergo Intensive Chemotherapy

Stemline Therapeutics

NCT06456463

RECRUITING Phase 1 80 participants

Cladribine, Idarubicin, Cytarabine, and Quizartinib in Treating Patients With Newly Diagnosed, Relapsed, or Refractory Acute Myeloid Leukemia or High-Risk Myelodysplastic Syndrome

M.D. Anderson Cancer Center

NCT04047641

RECRUITING Phase 1 80 participants

A Study of BTX-A51 in People With Relapsed or Refractory Acute Myeloid Leukemia or High-Risk Myelodysplastic Syndrome

Edgewood Oncology

NCT04243785

RECRUITING 80 participants

Immune Profile of Acute Myeloid Leukemia Patients Receiving Azacitidine Plus Venetoclax Induction Chemotherapy

Mayo Clinic

NCT06279572

RECRUITING Phase 1 75 participants

211^At-BC8-B10 Before Donor Stem Cell Transplant in Treating Patients With High-Risk Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Myelodysplastic Syndrome, or Mixed-Phenotype Acute Leukemia

Fred Hutchinson Cancer Center

NCT03128034

RECRUITING Early Phase 1 74 participants

Multi-modality Imaging and Collection of Biospecimen Samples in Understanding Bone Marrow Changes in Patients With Acute Myeloid Leukemia Undergoing TBI and Chemotherapy

City of Hope Medical Center

NCT03422731

RECRUITING Phase 1 73 participants

Quizartinib, Decitabine, and Venetoclax in Treating Participants With Untreated or Relapsed Acute Myeloid Leukemia or High Risk Myelodysplastic Syndrome

M.D. Anderson Cancer Center

NCT03661307

RECRUITING Phase 1 72 participants

SL-401 in Combination With Azacitidine or Azacitidine/Venetoclax in Acute Myeloid Leukemia (AML), High-Risk Myelodysplastic Syndrome (MDS) or Blastic Plasmacytoid Dendritic Cell Neoplasm (BPDCN)

Dana-Farber Cancer Institute

NCT03113643

RECRUITING Phase 2 70 participants

MT2021-08T Cell Receptor Alpha/Beta Depletion PBSC Transplantation for Heme Malignancies

Masonic Cancer Center, University of Minnesota

NCT05735717

RECRUITING NA 70 participants

Massage Impact on Sleep in Pediatric Oncology

Children's Hospital of Philadelphia

NCT06892158

RECRUITING Phase 2 70 participants

Cardioprotection in AML

University of Virginia

NCT04977180

RECRUITING Phase 1 68 participants

Pilot Study of Memory-like Natural Killer (ML NK) Cells After TCRαβ T Cell Depleted Haploidentical Transplant in AML

Washington University School of Medicine

NCT06158828

RECRUITING Phase 2 63 participants

Two Step Haplo With Radiation Conditioning

Thomas Jefferson University

NCT05031897

RECRUITING Phase 2 63 participants

Azacitidine and Enasidenib in Treating Patients With IDH2-Mutant Myelodysplastic Syndrome

M.D. Anderson Cancer Center

NCT03383575

RECRUITING Phase 1 62 participants

Venetoclax and CLAG-M for the Treatment of Acute Myeloid Leukemia and High-Grade Myeloid Neoplasms

University of Washington

NCT04797767

RECRUITING Phase 2 60 participants

Donor Stem Cell Transplant With Treosulfan, Fludarabine, and Total-Body Irradiation for the Treatment of Hematological Malignancies

Fred Hutchinson Cancer Center

NCT04195633

RECRUITING Phase 1 60 participants

Pilot Imaging Study of Leukemia

University of Oklahoma

NCT03633955

RECRUITING 60 participants

Refining the Role of Mid-induction Bone Marrow Biopsy in Acute Myeloid Leukemia: A Pilot Study

University of Alabama at Birmingham

NCT06323590

RECRUITING Phase 1 60 participants

Eltanexor and Venetoclax in Relapsed or Refractory Myelodysplastic Syndrome and Acute Myeloid Leukemia

Vanderbilt-Ingram Cancer Center

NCT06399640

RECRUITING Phase 1 58 participants

Edetate Calcium Disodium or Succimer in Treating Patients With Acute Myeloid Leukemia or Myelodysplastic Syndrome Undergoing Chemotherapy

M.D. Anderson Cancer Center

NCT03630991

RECRUITING Phase 1 54 participants

Pembrolizumab and Decitabine With or Without Venetoclax in Treating Patients With Acute Myeloid Leukemia or Myelodysplastic Syndrome That Is Newly-Diagnosed, Recurrent, or Refractory

City of Hope Medical Center

NCT03969446

RECRUITING Phase 2 54 participants

Cord Blood Transplant, Cyclophosphamide, Fludarabine, and Total-Body Irradiation in Treating Patients With High-Risk Hematologic Diseases

Fred Hutchinson Cancer Center

NCT06013423

RECRUITING Phase 1 54 participants

Testing the Anti-cancer Drug, Cirtuvivint, and Its Combination With ASTX727 to Improve Outcomes in Patients With Acute Myeloid Leukemia and Myelodysplastic Syndromes

National Cancer Institute (NCI)

NCT06484062

RECRUITING Phase 2 53 participants

Tagraxofusp and Azacitidine With Venetoclax in Newly Diagnosed Secondary AML After Hypomethylating Agents

Joshua Zeidner

NCT05442216

RECRUITING Phase 1 52 participants

Liposomal Cytarabine and Daunorubicin (CPX-351) and Quizartinib for the Treatment of Acute Myeloid Leukemia and High Risk Myelodysplastic Syndrome

M.D. Anderson Cancer Center

NCT04128748

RECRUITING Phase 1 52 participants

A Study of Revumenib and Mezigdomide in People With Leukemia

Memorial Sloan Kettering Cancer Center

NCT07356154

RECRUITING Phase 1 50 participants

Pharmacokinetic and Safety Study of MRX-2843 in Adolescents and Adults With Relapsed/Refractory AML, ALL, or MPAL

Meryx

NCT04872478

RECRUITING Phase 1 50 participants

A Phase 1 Trial of CIML NK Cell Infusion for Myeloid Disease Relapse After Hematopoietic Cell Transplantation

Dana-Farber Cancer Institute

NCT04024761

RECRUITING NA 50 participants

Evaluating the Effects of Hemoglobin Threshold-specific Packed Red Blood Cell Transfusions on Quality of Life and Functional Outcomes in Patients With High-grade Myeloid Neoplasms, Acute Myeloid Leukemia, or B Acute Lymphoblastic Lymphoma/Leukemia

University of Washington

NCT06710418

RECRUITING NA 50 participants

CD45RA Depleted Peripheral Stem Cell Addback for Viral or Fungal Infections Post TCRαβ/CD19 Depleted HSCT

Children's Hospital of Philadelphia

NCT03810196

RECRUITING Phase 1 48 participants

A Study of GLB-001 in Patients With Relapsed or Refractory Acute Myeloid Leukemia or Relapsed or Refractory Higher Risk Myelodysplastic Syndromes

GluBio Therapeutics

NCT06146257

RECRUITING Phase 1 45 participants

Testing the Combination of an Anti-Cancer Drug, Iadademstat, With Other Anti-Cancer Drugs (Venetoclax and Azacitidine) for Treating AML

National Cancer Institute (NCI)

NCT06514261

RECRUITING Phase 1 45 participants

HM2023-05: GTB-3650 Trike for High Risk MDS and R/R AML

Masonic Cancer Center, University of Minnesota

NCT06594445

RECRUITING Phase 2 45 participants

Interferon-γ (IFN-γ) With Donor Leukocyte Infusion to Treat Relapsed Acute Myeloid Leukemia and Myelodysplastic Syndromes Post Allogeneic Hematopoietic Stem Cell Transplantation

Sawa Ito, MD

NCT06529731

RECRUITING Phase 2 45 participants

A Study of the Combination of Ivosidenib, Azacitidine, and Venetoclax Followed by Ivosidenib Alone in People With Acute Myeloid Leukemia

Memorial Sloan Kettering Cancer Center

NCT07392242

RECRUITING Phase 1 44 participants

Study of Tagraxofusp for Post-Transplant Maintenance for Patients With CD 123+ AML, MDS, MF and CMML (HSCT 002)

Karen Ballen, MD

NCT05233618

RECRUITING Phase 1 44 participants

Dose Escalation and Expansion of Ziftomenib in Combination With Quizartinib in Acute Myeloid Leukemia

M.D. Anderson Cancer Center

NCT06769490

RECRUITING Phase 1 43 participants

Tagraxofusp and Azacitidine for Maintenance Treatment in Patients With CD123 Positive AML and MDS Following Donor Hematopoietic Cell Transplant

City of Hope Medical Center

NCT06498973

RECRUITING Phase 1 43 participants

A Phase I-II Study Investigating the All-Oral Combination of the Menin Inhibitor SNDX-5613 With Decitabine/Cedazuridine (ASTX727) and Venetoclax in Acute Myeloid Leukemia (SAVE)

M.D. Anderson Cancer Center

NCT05360160

RECRUITING Phase 1 42 participants

ASTX727, Venetoclax, and Gilteritinib for the Treatment of Newly Diagnosed, Relapsed or Refractory FLT3-Mutated Acute Myeloid Leukemia or High-Risk Myelodysplastic Syndrome

M.D. Anderson Cancer Center

NCT05010122

RECRUITING Phase 2 40 participants

Venetoclax in Combination With Cladribine and Cytarabine Alternating With Azacitidine Plus Venetoclax for the Treatment of Newly Diagnosed Monocytic AML and Active Signaling Mutated AML

OHSU Knight Cancer Institute

NCT06504459

RECRUITING Phase 1 40 participants

Phase I/II Trial: Engineered Donor Graft (Orca Q) for Pediatric Hematopoietic Cell Transplant (HCT)

University of Florida

NCT05322850

RECRUITING Phase 1 40 participants

A Phase Ia/Ib Open-label, Multiple Dose, Study to Determine the Recommended Dose, Evaluate PKs, PDs, Safety, and Activity of Venetoclax in Combination With Oral Decitabine/Cedazuridine (ASTX727) in Pediatric Patients With Relapsed/Refractory Acute Myeloid Leukemia (AML)

M.D. Anderson Cancer Center

NCT06191978

RECRUITING Phase 1 40 participants

A Study of ADCLEC.syn1 in People With Acute Myeloid Leukemia

Memorial Sloan Kettering Cancer Center

NCT05748197

RECRUITING Phase 2 40 participants

Ruxolitinib With Tacrolimus and Methotrexate for the Prevention of Graft Versus Host Disease in Pediatric and Young Adult Patients Undergoing Allogeneic Hematopoietic Cell Transplant for Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, or Myelodysplastic Syndrome

City of Hope Medical Center

NCT06128070

RECRUITING Phase 1 38 participants

Danvatirsen Monotherapy Followed by Combination With Venetoclax in Relapsed/Refractory MDS & AML

Montefiore Medical Center

NCT05986240

RECRUITING Phase 2 37 participants

Discontinuation of Hypomethylating Agent and Venetoclax in Patients With AML MRD

H. Lee Moffitt Cancer Center and Research Institute

NCT06511882

RECRUITING Phase 2 37 participants

A Pilot Study to Evaluate the Feasibility of Post-Hematopoietic Stem Cell Transplant Prophylaxis With Decitabine Combined With Filgrastim for Children and Young Adults With AML, MDS and Related Myeloid Malignancies

Franziska Wachter

NCT05796570

RECRUITING Phase 1 36 participants

Chemotherapy (Decitabine in Combination With FLAG-Ida) and Total-Body Irradiation Followed by Donor Stem Cell Transplant for the Treatment of Adults With Myeloid Malignancies at High Risk of Relapse

Fred Hutchinson Cancer Center

NCT06928662

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Phase Distribution

PhaseTrial count
Phase 1 160
Phase 2 105
Phase 3 12
Phase 4 1

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Acute Myeloid Leukemia Trial Landscape

307 indexed Acute Myeloid Leukemia studies · 159 recruiting (52%).

Phase mix: 13 late (III/IV) vs 265 early (I/II).

Top sponsor: M.D. Anderson Cancer Center (38 trials), 9 others listed. 50 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Acute Myeloid Leukemia?

PlainTrial tracks 307 US clinical trials for Acute Myeloid Leukemia, of which 159 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Acute Myeloid Leukemia?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.