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NCT06710418 · ClinicalTrials.gov registry record · NA
Evaluating the Effects of Hemoglobin Threshold-specific Packed Red Blood Cell Transfusions on Quality of Life and Functional Outcomes in Patients With High-grade Myeloid Neoplasms, Acute Myeloid Leukemia, or B Acute Lymphoblastic Lymphoma/Leukemia
A NA study of Acute Myeloid Leukemia and B Acute Lymphoblastic Leukemia, sponsored by University of Washington.
- Recruiting
- Registry status
- NA
- Development phase
- 50
- Enrollment target
- 1
- Study location
NCT06710418: Recruiting NA study of Acute Myeloid Leukemia and B Acute Lymphoblastic Leukemia, sponsored by University of Washington.
NCT06710418 is a NA study of Acute Myeloid Leukemia and B Acute Lymphoblastic Leukemia that is actively recruiting participants, run by University of Washington. The registered enrollment target is 50 participants, below the 116-participant average among 306 other Acute Myeloid Leukemia trials with a reported enrollment target (57% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06710418, a NA study of Acute Myeloid Leukemia and B Acute Lymphoblastic Leukemia, is actively recruiting participants, sponsored by University of Washington.
- RECRUITING
- Registry status
- NA
- Development phase
- 50 participants
- Enrollment target
- 1
- Study location
Study Summary
This clinical trial evaluates the effects of hemoglobin threshold-specific packed red blood cell (PRBC) transfusions on quality of life and functional outcomes in patients who have undergone chemotherapy or an allogeneic hematopoietic stem cell transplant for a high-grade myeloid neoplasm, acute myeloid leukemia, or B acute lymphoblastic lymphoma/leukemia. Some types of chemotherapy and stem cell transplants can induce low platelet counts and/or anemia that requires PRBC transfusions. Given critical shortages in blood supply, and risks associated with transfusion of PRBC, there has been much investigation into the "minimum" hemoglobin level that effectively balances safety and toxicity in patients. This clinical trial evaluates the effects of giving PRBC transfusions based on a more restrictive hemoglobin threshold (\> 7 gm/dL) compared to a more liberal hemoglobin threshold (\> 9 gm/dL) on quality of life and functional outcomes. A more restrictive threshold may be just as effective at maintaining patient quality of life and function while decreasing side effects from blood transfusions and helping to conserve blood supply resources.
Primary Outcome
Randomizing patients to two different transfusion thresholds will be considered feasible if greater than 50% of eligible patients consent.
Conditions Studied
Interventions
- PROCEDURE Biospecimen Collection
- OTHER Electronic Health Record Review
- PROCEDURE Cognitive Assessment
- OTHER Activity Tracking
- OTHER Packed Red Blood Cell Transfusion
Study Locations (1)
Washington
- Fred Hutch/University of Washington Cancer Consortium - Seattle
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 50 participants |
| Start Date | 2025-10-15 |
| Est. Completion | 2027-12-31 |
| Phase | NA |
What NCT06710418 shows while recruiting
NCT06710418 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 50 participants, a relatively small participant target, below the 116-participant average among 306 other Acute Myeloid Leukemia trials with a reported enrollment target (57% lower).
The record links to 4 conditions, with Acute Myeloid Leukemia appearing as the primary indexed condition, and to 5 interventions - of which Biospecimen Collection is the first listed.
NCT06710418 reports a single indexed study location in Washington.
Frequently Asked Questions
What is clinical trial NCT06710418 about?
NCT06710418 is a clinical study titled "Evaluating the Effects of Hemoglobin Threshold-specific Packed Red Blood Cell Transfusions on Quality of Life and Functional Outcomes in Patients With High-grade Myeloid Neoplasms, Acute Myeloid Leukemia, or B Acute Lymphoblastic Lymphoma/Leukemia". This clinical trial evaluates the effects of hemoglobin threshold-specific packed red blood cell (PRBC) transfusions on quality of life and functional outcomes in patients who have undergone chemotherapy or an allogeneic hematopoietic stem cell transplant for a high-grade myeloid neoplasm, acute mye...
What is the current status of trial NCT06710418?
This trial is currently recruiting. It is a NA study. The enrollment target is 50 participants. The study started on 2025-10-15. Estimated completion is 2027-12-31.
What conditions does trial NCT06710418 study?
This clinical trial studies the following conditions: Acute Myeloid Leukemia, B Acute Lymphoblastic Leukemia, Myeloid Neoplasm, B Lymphoblastic Lymphoma.
What interventions are being tested in trial NCT06710418?
The interventions under investigation include: Biospecimen Collection (PROCEDURE), Electronic Health Record Review (OTHER), Cognitive Assessment (PROCEDURE), Activity Tracking (OTHER), Packed Red Blood Cell Transfusion (OTHER).
Who is sponsoring clinical trial NCT06710418?
This trial is sponsored by University of Washington, which has 1,048 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06710418 being conducted?
This trial has 1 study location across Washington. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT06710418's enrollment target sits among peer trials
50 143rd of 306 higher than 154 of 306 other Acute Myeloid Leukemia trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Acute Myeloid Leukemia trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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