Yale University

Open enrollment with an early-phase pipeline tilt

According to ClinicalTrials.gov-derived indexes, Yale University sits in the top decile of US sponsors by registered trial count (#13 of 15,742 sponsors by registered trial count).

1,492 total trials 254 currently recruiting 1005 completed early-phase tilt top decile by trial count

Yale University: 1,492 sponsored US clinical trials, 254 recruiting.

Yale University sponsors 1,492 registered US clinical trials on ClinicalTrials.gov, 254 of them currently recruiting, and 1,005 completed. 99 of these trials are in Phase 3-4 (later-stage) and 579 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Opioid Use Disorder, with 19 trials.

Top-decile sponsor footprint

Yale University ranks in the top decile of sponsors by registered trial count (#13 of 15,742 sponsors by registered trial count). Volume at this scale usually reflects a long institutional pipeline, read phase tilt and therapeutic areas below before treating it as current-year activity.

Trial completion reliability score

D 60/100

1,005 of 1,138 decided trials (Completed vs. Terminated on ClinicalTrials.gov) reached their planned completion (88.3%), vs. national p10 68.4% / p90 100% among 1,234 sponsors with at least 10 decided trials. Still-open trials (Recruiting, Active-not-recruiting, Not-yet-recruiting) are excluded since they have not reached an outcome yet.

Open and recent trials

1,492 total, page 27 of 30

COMPLETED NA

Galantamine Effects on Cognitive Function in Abstinent Cocaine Users

NCT00606801

COMPLETED Phase 1

Phase I Study of the Combination of Satraplatin and Abraxane in Advanced Cancers

NCT00473720

COMPLETED Phase 2

The Effect of Varenicline (Chantix) and Bupropion (Zyban) on Smoking Lapse Behavior

NCT00580853

COMPLETED NA

Effective Treatment of Hepatitis C in Substance Users

NCT00633243

COMPLETED

Examining New Diagnostic Tests for Acute Kidney Injury After Heart Surgery

NCT00774137

COMPLETED Phase 2

Do Treatments for Smoking Cessation Affect Alcohol Drinking?

NCT00580645

TERMINATED Phase 4

Study of Lunesta Versus Placebo for Sleep Problems Related to Smoking Cessation and Zyban

NCT00511134

COMPLETED Phase 2

Trial of Gemcitabine, Carboplatin, and Sorafenib in Chemotherapy-naive Patients With Advanced/Metastatic Bladder Carcinoma

NCT00461851

COMPLETED Phase 1

The Effect of Plasma Osmolality on Brain Glutamate

NCT00611741

COMPLETED NA

Efficacy of Varenicline in Methadone-Stabilized Cocaine Users

NCT00567320

TERMINATED Phase 2

Randomized Phase II Study of Preoperative Letrozole (Femara) in Combination With Avastin in Hormone Receptor Positive Breast Cancer

NCT00461773

COMPLETED Early Phase 1

Effects of Duloxetine on Fear Conditioning in Posttraumatic Stress Disorder (PTSD)

NCT00763178

COMPLETED Phase 1

The Effect of Protein Supplementation on Bone Health in Healthy Older Men and Women

NCT00421408

COMPLETED

Effect of Music Therapy on Patients Undergoing Intravitreal Injections

NCT00702039

COMPLETED Phase 3

Effectiveness of Paricalcitol in Reducing Parathyroid Hormone (PTH) Levels in X-linked Hypophosphatemic Rickets

NCT00417612

COMPLETED Phase 2

Levetiracetam (Keppra) Tolerability in Cocaine Abusing Methadone-maintained Patients.

NCT00593125

COMPLETED Early Phase 1

Interactive Psychopharmacologic Effects of Alcohol and Nicotine in Humans

NCT00616746

COMPLETED Phase 1

GABA-glutamate Interactions and Psychosis

NCT00611572

COMPLETED NA

Pharmacokinetic Interactions Between Buprenorphine and Kaletra (Lopinavir/Ritonavir)

NCT00571961

COMPLETED NA

Cranberry for UTI Prevention in Residents of Long Term Care Facilities

NCT00596635

COMPLETED NA

The Effect of Cycloserine on Smoking Behavior in Nicotine Dependent Smokers

NCT00633256

COMPLETED Phase 2

A Phase II Study of Rapamycin and Trastuzumab for Patients With HER-2 Receptor Positive Metastatic Breast Cancer

NCT00411788

COMPLETED NA

Recovery Guide Intervention for Recurrent Psychiatric Hospitalization

NCT00400166

COMPLETED Phase 1

A Phase I/II, Multi-Center, Open-Label, Dose-Escalation, Safety and Efficacy Study of PHY906 Plus Capecitabine in Patients With Advanced Pancreatic Carcinoma

NCT00411762

COMPLETED Phase 2

Effects of Recombinant Human Erythropoietin on Platelet Function in Patients With Acute Myocardial Infarction

NCT00367991

TERMINATED

Early Detection of Glioblastoma Multiforme (GBM) Treatment Responses Using Multiple Magnetic Resonance Modalities

NCT00589095

COMPLETED NA

Effects of Weight Loss on Hepatic and Muscle Lipid Content and on Insulin Sensitivity on Obese Adolescents With NAFLD

NCT00585299

COMPLETED Phase 2

Riluzole Augmentation in Treatment-refractory Obsessive-compulsive Disorder

NCT00523718

COMPLETED Phase 3

Treatment With Acamprosate in Patients With Schizophrenia and Comorbid Alcoholism

NCT00463346

COMPLETED Phase 2

Anti-CD3 mAb Treatment of Recent Onset Type 1 Diabetes

NCT00378508

COMPLETED

Why Are Patients With Absence Seizures Absent? A Brain Imaging Study

NCT00393666

COMPLETED

Safety of Sports for Patients With Implantable Cardioverter-Defibrillators

NCT00637754

TERMINATED Phase 4

Study of Post-meal Blood Sugar Peaks in Association With Vascular Disease in Childhood Obesity

NCT00846521

COMPLETED

Simulation Training for Ultrasound Guided Central Venous Catheter Insertion

NCT00919308

COMPLETED NA

Modafinil, Sleep, and Cognition in Cocaine Dependence

NCT00582491

COMPLETED Phase 2

A Trial of Extracorporeal Photopheresis, Pentostatin, and Total Body Irradiation in Patients Undergoing Reduced Intensity Allogeneic Stem Cell Transplantation for the Treatment of Malignancies

NCT00402714

COMPLETED Phase 2

Reducing Sex-Related HIV Risk Behaviors in Patients Receiving Treatment for Opioid Dependence

NCT00548275

COMPLETED Phase 2

Family History Study of Alcohol Consumption Using Memantine

NCT00630955

COMPLETED Phase 2

Bevacizumab and Chemoembolization in Treating Patients With Liver Cancer That Cannot Be Removed By Surgery

NCT00335829

COMPLETED NA

Pharmacokinetic Interactions Between Buprenorphine and Tipranavir/Ritonavir

NCT00486330

COMPLETED NA

Mammosite Breast Brachytherapy Optimization in the Treatment of Breast Carcinoma

NCT00611624

TERMINATED Phase 1

Docetaxel With or Without Phenoxodiol in Treating Patients With Recurrent Advanced Ovarian Epithelial Cancer, Fallopian Tube Cancer, or Primary Peritoneal Cavity Cancer

NCT00303888

COMPLETED Phase 1

Guanfacine to Reduce Stress-Induced Cocaine/Alcohol Craving and Relapse

NCT00585754

COMPLETED NA

Specialized Treatment Early in Psychosis (STEP)

NCT00309452

COMPLETED NA

Tele-HF: Yale Heart Failure Telemonitoring Study

NCT00303212

COMPLETED Phase 2

Glycine vs Placebo for the Schizophrenia Prodrome

NCT00291226

TERMINATED Phase 1

Dialysate Sodium Individualization in Hemodialysis

NCT00259714

COMPLETED Phase 2

Sex Hormones and Orthostatic Tolerance

NCT01153581

COMPLETED Phase 2

Transcranial Magnetic Stimulation for "Voices"

NCT00308997

TERMINATED Phase 1

Study of Combination of Sirolimus and Sutent in Patients With Advanced Solid Tumors Non-Curable With Standard Therapy

NCT00402415

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Phase Distribution

PhaseTrial count
Phase 1 312
Phase 2 267
Phase 3 52
Phase 4 47

What is open in the Yale University pipeline

254 recruiting of 1,492 indexed (17% open); 1,005 completed (67%).

Phase mix: 99 late (III/IV) vs 579 early (I/II) (early-phase heavy).

Top condition: Opioid Use Disorder (19 trials), 9 others listed.

How open-pipeline share is computed

Recruiting share is recruiting_count divided by trial_count for this sponsor in the public registry export. Status can change between pulls; treat the figure as a research-attention snapshot, not product availability.

Yale University: open-pipeline peers nationwide

Peers matched on 1,492 registered trials and 17% open enrollment, not the therapeutic-area sidebar.

Yale University sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot). 2×2 strategic matrix plotting 9 entities by Total trials (X) and Recruiting share (Y), with a crosshair dividing the plot into four quadrants. Higher volume & more openFocused & more openHigher volume, mostly closedSmaller & mostly closed 05001,0001,5002,000 5%10%15%20% Total trials Recruiting share Yale UniversityWashington University School of MedicineJohns Hopkins UniversityUniversity of PennsylvaniaNovartis PharmaceuticalsNYU Langone HealthCSL BehringPenn State UniversityUniversity of Hawaii
Yale University sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot).

Yale University sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together.

Sponsors near 1,492 trials (± recruiting share)

Sponsors near 17% open enrollment (± trial volume)

What to do with this Yale University page

1,492 registered trials is a research-attention snapshot, not an endorsement of Yale University or any single study.

  • 254 of Yale University's trials are currently recruiting, check each one's own eligibility criteria before contacting a site. Browse recruiting trials
  • Opioid Use Disorder is the condition Yale University studies most, compare against other sponsors active in the same condition before evaluating a specific study. See Opioid Use Disorder trials
  • Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. Yale University pipeline card: 1,492 registered trials from official public datasets. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.