The Cleveland Clinic

Open enrollment across a mixed-phase pipeline

According to ClinicalTrials.gov-derived indexes, The Cleveland Clinic sits in the top decile of US sponsors by registered trial count (#50 of 15,742 sponsors by registered trial count).

688 total trials 99 currently recruiting 437 completed top decile by trial count

The Cleveland Clinic: 688 sponsored US clinical trials, 99 recruiting.

The Cleveland Clinic sponsors 688 registered US clinical trials on ClinicalTrials.gov, 99 of them currently recruiting, and 437 completed. 81 of these trials are in Phase 3-4 (later-stage) and 76 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Atrial Fibrillation, with 9 trials.

Top-decile sponsor footprint

The Cleveland Clinic ranks in the top decile of sponsors by registered trial count (#50 of 15,742 sponsors by registered trial count). Volume at this scale usually reflects a long institutional pipeline, read phase tilt and therapeutic areas below before treating it as current-year activity.

Trial completion reliability score

F 42/100

437 of 539 decided trials (Completed vs. Terminated on ClinicalTrials.gov) reached their planned completion (81.1%), vs. national p10 68.4% / p90 100% among 1,234 sponsors with at least 10 decided trials. Still-open trials (Recruiting, Active-not-recruiting, Not-yet-recruiting) are excluded since they have not reached an outcome yet.

Open and recent trials

688 total, page 9 of 14

COMPLETED Phase 3

Use of 6% Hydroxyethylstarch (130/0.4) in Cardiac Surgical Patients

NCT02192502

COMPLETED Phase 2

The COMBINE Study: The CKD Optimal Management With BInders and NicotinamidE

NCT02258074

COMPLETED NA

Evaluation of 3D Visualization for Total Colectomy

NCT02370056

COMPLETED Phase 1

Pomalidomide in Hereditary Hemorrhagic Telangiectasia and Transfusion-Dependent Vascular Ectasia: a Phase I Study

NCT02287558

COMPLETED

Measure of Frailty in Perioperative Setting

NCT02838511

COMPLETED NA

Effect of the Built Operating Room Environment on Patient Outcome

NCT03037905

TERMINATED NA

T-ABA Group Based Early Intervention For Parents of Children With ASD

NCT02202421

TERMINATED

Incisional Hernia and Adhesion-Related Bowel Obstruction

NCT02116881

COMPLETED Phase 3

Effect of Intravenous Acetaminophen on Postoperative Opioid-related Complications

NCT02156154

COMPLETED

Neurotrophin Expression in Infants as a Predictor of Respiratory and Neurodevelopmental Outcomes

NCT03373539

TERMINATED Phase 2

Establishing the Microcirculatory Effects of Ticagrelor on Tissue Perfusion in Critical Limb Ischemia

NCT02230527

COMPLETED

Residual Gastric Volume in Same Day Versus Split Dose and Evening Before Bowel Preparation

NCT02264249

COMPLETED NA

Comparison of Glenoid Position Using SmartBones

NCT03035318

COMPLETED NA

Chronic Kidney Disease Knowledge and Awareness Among American Indians

NCT02309528

COMPLETED Phase 4

Efficacy of Liposomal Bupivacaine for Prolonged Postoperative Analgesia in Patient Undergoing Breast Reconstruction With Tissue Expander

NCT04278846

COMPLETED

Using Smart Phone Technology in Detecting the Presence of Atrial Fibrillation

NCT02214069

TERMINATED NA

Real Time 3D Imaging and Surrogate Bone Model

NCT02204007

TERMINATED NA

Mediterranean Diet and Protein-Sparing Modified Diet for Metabolic Syndrome in Liver Transplant Recipients

NCT02174783

COMPLETED NA

Evaluation of Wound Management With Negative Pressure Dressing Versus Standard Dressing After Revision Arthroplasty.

NCT02127281

COMPLETED Phase 4

Effects of Donepezil HCL on Task-Activated fMRI Brain Activation in Healthy Older Adults at Genetic Risk for Alzheimer's Disease

NCT02087865

COMPLETED NA

Examining the Efficacy of Mattress Technology in Improving the Sleep Quality of Children With ASD

NCT02739321

TERMINATED NA

Effect of the Temperature Used in Thermal Radiofrequency Ablation

NCT02148003

COMPLETED NA

Randomized Trial of Y Mesh vs Dual Mesh

NCT02156687

COMPLETED NA

Optimal Positioning of Nasopharyngeal Temperature Probes: A Prospective Cohort Study

NCT02042625

COMPLETED Phase 3

Protocols for Painless Photodynamic Therapy (PDT) of Actinic Keratoses

NCT02124733

COMPLETED NA

Use of Time-lapse Morphological Kinetics in the Selection of Blastocysts

NCT02081859

COMPLETED NA

Reducing Post-Op Pain After Sacrospinous Ligament Colpopexy

NCT02037061

COMPLETED NA

Cooled Radiofrequency Ablation vs. Thermal Radiofrequency Ablation

NCT02073292

COMPLETED NA

Silk-Like Bed Linens for Prevention of Unit-Acquired Ulcers

NCT02925741

COMPLETED Early Phase 1

Systemic Normothermia in Intracerebral Hemorrhage (ICH)

NCT02078037

COMPLETED NA

Needle Guidance in Ultrasound Guided Nerve Blocks

NCT02080481

COMPLETED NA

Effects of a Home Based Walking Program Using Rhythmic Auditory Stimulation in Patients With Multiple Sclerosis

NCT02065284

COMPLETED NA

REstrictive Versus LIbEral Fluid Therapy in Major Abdominal Surgery

NCT02073162

COMPLETED

Endothelial Function in Patients With Scleroderma or Cirrhosis With and Without Pulmonary Hypertension

NCT01729611

COMPLETED NA

Impact of Influenza Vaccination in Pregnancy Video Education

NCT02151201

COMPLETED NA

Use of Capnography in EGD and Colonoscopy With Moderate Sedation.

NCT01994785

COMPLETED Phase 2

Cyclosporine in Interstitial Cystitis: Efficacy, Safety and Mechanism of Action

NCT01990898

TERMINATED Phase 2

TRACER RGD-K5 Carotid Plaque Imaging Study

NCT01968226

TERMINATED

Real-Time Instrument for Acetabular Shell Positioning

NCT02006251

COMPLETED NA

Use of Real Time Instrumentation (RTI) in Total Shoulder Arthroplasty

NCT01905241

COMPLETED

Natural History of Cherubism Observational Study

NCT01916772

COMPLETED NA

Interventions to Decrease Anxiety in Patients Undergoing Urodynamic Testing

NCT02168556

COMPLETED

Evaluating the Efficacy and Feasibility of a Novel Wireless ECG Recording System in Monitoring Patients After Atrial Fibrillation Ablation Procedure

NCT01912911

COMPLETED Phase 4

Ancillary Effects of Dexmedetomidine Sedation After Cardiac Surgery

NCT02004613

COMPLETED NA

a Diagnostic SIJ Injection Following a Composite of 3 Diagnostic Tests and a Pain Referral Diagram

NCT01875406

COMPLETED NA

The Cyclical Lower-extremity Exercise for Parkinson's Trial

NCT01636297

TERMINATED Phase 1

Trial of Cooling for Patients With Excel Cryo Cooling System in Intracerebral Hemorrhage (ICH)

NCT01933230

COMPLETED NA

Acupuncture on Cardiac and Autonomic Function in Human Heart Failure

NCT01804816

COMPLETED

Organ Donor Tissue Oxygen Saturation as a Predictor of Number of Organs to Transplant Per Donor

NCT01819116

TERMINATED NA

Vitagel Revision Total Knee Arthroplasty

NCT01923805

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Phase Distribution

PhaseTrial count
Phase 1 38
Phase 2 38
Phase 3 22
Phase 4 59

What is open in the The Cleveland Clinic pipeline

99 recruiting of 688 indexed (14% open); 437 completed (64%).

Phase mix: 81 late (III/IV) vs 76 early (I/II) (balanced across stages).

Top condition: Atrial Fibrillation (9 trials), 9 others listed.

How open-pipeline share is computed

Recruiting share is recruiting_count divided by trial_count for this sponsor in the public registry export. Status can change between pulls; treat the figure as a research-attention snapshot, not product availability.

The Cleveland Clinic: open-pipeline peers nationwide

Peers matched on 688 registered trials and 14% open enrollment, not the therapeutic-area sidebar.

The Cleveland Clinic sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot). 2×2 strategic matrix plotting 9 entities by Total trials (X) and Recruiting share (Y), with a crosshair dividing the plot into four quadrants. Higher volume & more openFocused & more openHigher volume, mostly closedSmaller & mostly closed 02004006008001,000 5%10%15%20%25% Total trials Recruiting share The Cleveland ClinicVanderbilt University Medical CenterWeill Medical College of Cornell UniversityIcahn School of Medicine at Mount SinaiSanofiDana-Farber Cancer InstituteModernaTXMasonic Cancer Center, University of MinnesotaAcademic and Community Cancer Research United
The Cleveland Clinic sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot).

The Cleveland Clinic sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together.

Sponsors near 688 trials (± recruiting share)

Sponsors near 14% open enrollment (± trial volume)

What to do with this The Cleveland Clinic page

688 registered trials is a research-attention snapshot, not an endorsement of The Cleveland Clinic or any single study.

  • 99 of The Cleveland Clinic's trials are currently recruiting, check each one's own eligibility criteria before contacting a site. Browse recruiting trials
  • Atrial Fibrillation is the condition The Cleveland Clinic studies most, compare against other sponsors active in the same condition before evaluating a specific study. See Atrial Fibrillation trials
  • Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. The Cleveland Clinic pipeline card: 688 registered trials from official public datasets. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.