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NCT02087865 · ClinicalTrials.gov registry record · Phase 4
Effects of Donepezil HCL on Task-Activated fMRI Brain Activation in Healthy Older Adults at Genetic Risk for Alzheimer's Disease
A Phase 4 study, sponsored by The Cleveland Clinic.
- Completed
- Registry status
- Phase 4
- Development phase
- 89
- Enrollment target
NCT02087865: Completed Phase 4 study, sponsored by The Cleveland Clinic.
NCT02087865 is a Phase 4 study that has completed, run by The Cleveland Clinic. The registered enrollment target is 89 participants, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (83% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02087865, a Phase 4 study, has completed, sponsored by The Cleveland Clinic.
- COMPLETED
- Registry status
- Phase 4
- Development phase
- 89 participants
- Enrollment target
Study Summary
This study examines the sensitivity of functional MRI to detect brain changes caused by donepezil HCL (a cholinesterase inhibitor) in healthy older adults at genetic risk for Alzheimer's Disease.
Primary Outcome
Changes from baseline to 24 weeks follow-up fMRI - Left posterior cingulate BOLD signal at 24 weeks, adjusting for baseline left posterior cingulate BOLD signal.
Interventions
- DRUG Placebo
- DRUG donepezil HCL
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 89 participants |
| Start Date | 2014-05 |
| Est. Completion | 2021-12-20 |
| Phase | Phase 4 |
What the finished NCT02087865 record still lists
NCT02087865 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 89 participants, a relatively small participant target, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (83% lower).
The record links to 0 conditions, and to 2 interventions - of which Placebo is the first listed.
NCT02087865 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT02087865 about?
NCT02087865 is a clinical study titled "Effects of Donepezil HCL on Task-Activated fMRI Brain Activation in Healthy Older Adults at Genetic Risk for Alzheimer's Disease". This study examines the sensitivity of functional MRI to detect brain changes caused by donepezil HCL (a cholinesterase inhibitor) in healthy older adults at genetic risk for Alzheimer's Disease.
What is the current status of trial NCT02087865?
This trial is currently completed. It is a Phase 4 study. The enrollment target is 89 participants. The study started on 2014-05. Estimated completion is 2021-12-20.
What interventions are being tested in trial NCT02087865?
The interventions under investigation include: Placebo (DRUG), donepezil HCL (DRUG).
Who is sponsoring clinical trial NCT02087865?
This trial is sponsored by The Cleveland Clinic, which has 688 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT02087865's enrollment target sits among peer trials
89 913th of 2000 higher than 1,085 of 2,000 other Phase 4 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 4 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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