The Cleveland Clinic

Open enrollment across a mixed-phase pipeline

According to ClinicalTrials.gov-derived indexes, The Cleveland Clinic sits in the top decile of US sponsors by registered trial count (#50 of 15,742 sponsors by registered trial count).

688 total trials 99 currently recruiting 437 completed top decile by trial count

The Cleveland Clinic: 688 sponsored US clinical trials, 99 recruiting.

The Cleveland Clinic sponsors 688 registered US clinical trials on ClinicalTrials.gov, 99 of them currently recruiting, and 437 completed. 81 of these trials are in Phase 3-4 (later-stage) and 76 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Atrial Fibrillation, with 9 trials.

Top-decile sponsor footprint

The Cleveland Clinic ranks in the top decile of sponsors by registered trial count (#50 of 15,742 sponsors by registered trial count). Volume at this scale usually reflects a long institutional pipeline, read phase tilt and therapeutic areas below before treating it as current-year activity.

Trial completion reliability score

F 42/100

437 of 539 decided trials (Completed vs. Terminated on ClinicalTrials.gov) reached their planned completion (81.1%), vs. national p10 68.4% / p90 100% among 1,234 sponsors with at least 10 decided trials. Still-open trials (Recruiting, Active-not-recruiting, Not-yet-recruiting) are excluded since they have not reached an outcome yet.

Open and recent trials

688 total, page 11 of 14

COMPLETED

Vaginal Uphold Hysteropexy and Laparoscopic Sacral Hysteropexy for the Treatment of Uterovaginal Pelvic Organ Prolapse

NCT01377142

TERMINATED NA

Study of Exelon Transdermal Patch in Amnestic Mild Cognitive Impairment Patients

NCT01602198

COMPLETED NA

Stress Free Now in a Corporate Call Center

NCT02087891

TERMINATED Phase 1

Alefacept in Patients With Relapsed/Refractory Aplastic Anemia

NCT01267643

COMPLETED NA

Vapocoolant (Pain Ease) Use for Venipuncture

NCT01712776

COMPLETED NA

Assessment of Voiding After Sling

NCT01343784

COMPLETED

Diagnostic and Prognostic Value of Serial Procalcitonin (PCT) Measurements in Critically Ill Patients

NCT01362920

COMPLETED Phase 1

Autologous Mesenchymal Stem Cell (MSC) Transplantation in MS

NCT00813969

COMPLETED NA

Electrical Stimulation of the Sphenopalatine Ganglion for the Treatment of Migraine Headaches

NCT01294046

COMPLETED

Gluconeogenesis Rates and Its Precursors in Pediatric Sepsis

NCT01890928

COMPLETED NA

Comparative Study Between Two Fecal Management Systems

NCT01411488

COMPLETED NA

The Glucagon Stimulation Test for Evaluation of Adult Growth Hormone Deficiency and Adrenocorticotropic Axis

NCT01282164

COMPLETED Phase 1

Acetabular Shell Positioning Using Patient Specific Instruments

NCT01791738

COMPLETED NA

Effect of Nitrous Oxide in Treating Neuropathic Pain: A Study in Chronic Low Back Pain Patients

NCT01172600

COMPLETED NA

Effect of Bariatric Surgery on Mechanisms of Type 2 Diabetes

NCT01278823

COMPLETED NA

A Prospective Study to Evaluate the Effectiveness of a Haemostatic Agent in Primary Unilateral Total Hip Arthroplasty

NCT01285024

COMPLETED NA

Effect of Goal-directed Crystalloid Versus Colloid Administration on Major Postoperative Morbidity

NCT01195883

COMPLETED Phase 2

Pentoxifylline for Primary Biliary Cirrhosis

NCT01249092

COMPLETED NA

The Effects of Dexmedetomidine and Propofol on Cerebral Blood Flow and Brain Oxygenation During Deep Brain Stimulation

NCT01200433

COMPLETED NA

The Effect of the Hyperinsulinemic Normoglycemic Clamp on Myocardial Function and Utilization of Glucose

NCT01187329

TERMINATED Phase 4

Switching From Efavirenz to Atazanavir/ Ritonavir in HIV-infected Subjects With Good Virologic Suppression

NCT01194856

COMPLETED NA

Patient Specific Instruments Versus Standard Surgical Instruments

NCT01430468

COMPLETED NA

Effectiveness of Stress Free Now: an Internet-based Mindfulness Program for Stress Management

NCT01595555

COMPLETED NA

Evaluation of the Trabecular Metal™ Revision Hip Cup Using Bone Mineral Density (DEXA)

NCT01183260

COMPLETED

Carotid Artery Neovascularization in Takayasu's and Giant Cell Arteritis

NCT01795456

COMPLETED Phase 4

Randomized Controlled Trial to Assess Effects of Lacosamide on Sleep and Wake in Adults With Focal Epilepsy

NCT01190098

COMPLETED Phase 2

Effects of Intentional Weight Loss Interventions in Chronic Kidney Disease

NCT01180101

TERMINATED NA

Regional Anesthesia and Lung Cancer Recurrence

NCT01179308

COMPLETED NA

Face Transplantation Clinical Trial

NCT01269164

COMPLETED

A Prospective Cohort Study to Describe the Evolution of Persistent Hyperparathyroidism in Kidney Transplant Recipients

NCT01163669

TERMINATED Phase 3

Vitamin D Supplement Study for Stage Three and Four Chronic Kidney Disease (CKD) Patients

NCT01173848

TERMINATED Phase 3

Renal Allograft Function and Histology Following Switching From A Tacrolimus to Sirolimus (SRL)-Based Immunosuppression-

NCT01166724

TERMINATED NA

Effect of Bispectral Index (BIS) Titrated Propofol Sedation on Lower Esophageal Sphincter Pressures and Esophageal Function in Intensive Care Patients

NCT01173263

COMPLETED NA

Effects of a Wholegrain Diet on Body Composition and Energy Balance

NCT01411540

COMPLETED

Lower Urinary Tract Infection (UTI) Evaluation in Women With Uterine Leiomyomata

NCT01123603

COMPLETED

Genetics, Brain Structure and Thinking Skills in Autism

NCT01451983

COMPLETED Early Phase 1

Gut Flora Dependent Metabolism of Dietary Phosphatidylcholine and Cardiovascular Disease

NCT01519310

COMPLETED NA

Enhancing Donated After Cardiac Death (DCD) Utilization With Thrombolytic Therapy

NCT01197573

TERMINATED NA

Prevention of Catheter-Associated Urinary Tract Infection in Incontinence and Reconstructive Pelvic Surgery Patients

NCT01108757

COMPLETED NA

A Randomized Comparison of Intraoperative Warming With the LMA PerfecTemp and Forced-air

NCT01094119

COMPLETED

Pulmonary Hypertension and Imatinib

NCT01092897

COMPLETED NA

Accuracy of the Drager Dual-sensor Temperature Measurement System

NCT00980642

COMPLETED

Implantable Loop Recorders in Post-atrial Fibrillation (AF) Ablation: RPAF-A

NCT01061125

COMPLETED NA

Creatine Kinetics, Synthesis From Glycine and Response to Creatine and Amino Acid Supplement in Healthy Humans

NCT01725503

COMPLETED NA

Coenzyme Q-10 and Pulmonary Arterial Hypertension

NCT01148836

COMPLETED NA

Electrohydraulic Versus Laser Lithotripsy for Treatment of Difficult to Remove Biliary Stones

NCT01571271

TERMINATED NA

An International Double Cohort Study to Compare Laparoscopic Ventral Rectopexy With Laparoscopic Resection Rectopexy

NCT01595412

COMPLETED NA

Effects of Exercise and Cognitive Training on Cognitive Function in Older Adults

NCT01038726

TERMINATED NA

Comparison of Direct Laryngoscopy, Truview EVO2 and Glidescope in Pediatric Patients

NCT01023568

COMPLETED NA

A Comparison of Methods to Detect Polyps During Colonoscopy

NCT01025960

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Phase Distribution

PhaseTrial count
Phase 1 38
Phase 2 38
Phase 3 22
Phase 4 59

What is open in the The Cleveland Clinic pipeline

99 recruiting of 688 indexed (14% open); 437 completed (64%).

Phase mix: 81 late (III/IV) vs 76 early (I/II) (balanced across stages).

Top condition: Atrial Fibrillation (9 trials), 9 others listed.

How open-pipeline share is computed

Recruiting share is recruiting_count divided by trial_count for this sponsor in the public registry export. Status can change between pulls; treat the figure as a research-attention snapshot, not product availability.

The Cleveland Clinic: open-pipeline peers nationwide

Peers matched on 688 registered trials and 14% open enrollment, not the therapeutic-area sidebar.

The Cleveland Clinic sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot). 2×2 strategic matrix plotting 9 entities by Total trials (X) and Recruiting share (Y), with a crosshair dividing the plot into four quadrants. Higher volume & more openFocused & more openHigher volume, mostly closedSmaller & mostly closed 02004006008001,000 5%10%15%20%25% Total trials Recruiting share The Cleveland ClinicVanderbilt University Medical CenterWeill Medical College of Cornell UniversityIcahn School of Medicine at Mount SinaiSanofiDana-Farber Cancer InstituteModernaTXMasonic Cancer Center, University of MinnesotaAcademic and Community Cancer Research United
The Cleveland Clinic sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together. Source: ClinicalTrials.gov (2026-08-08 snapshot).

The Cleveland Clinic sits at or above the median trial volume and at or above the median recruiting share among these 9 nationwide peers -- the two do not always move together.

Sponsors near 688 trials (± recruiting share)

Sponsors near 14% open enrollment (± trial volume)

What to do with this The Cleveland Clinic page

688 registered trials is a research-attention snapshot, not an endorsement of The Cleveland Clinic or any single study.

  • 99 of The Cleveland Clinic's trials are currently recruiting, check each one's own eligibility criteria before contacting a site. Browse recruiting trials
  • Atrial Fibrillation is the condition The Cleveland Clinic studies most, compare against other sponsors active in the same condition before evaluating a specific study. See Atrial Fibrillation trials
  • Bring the specific trial ID (NCT number) to your own doctor before enrolling, this page is a directory, not medical guidance. Read the trial-finding guide

Trial and recruiting counts reflect ClinicalTrials.gov registry status as of the data vintage above; individual trial eligibility and enrollment status can change.

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. The Cleveland Clinic pipeline card: 688 registered trials from official public datasets. See our editorial standards & corrections policy, the methodology behind these numbers, the data changelog, or report a data error.