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NCT06233799 · ClinicalTrials.gov registry record · Phase 3
Trial of Naltrexone/Bupropion for the Treatment of Methamphetamine Use Disorder
A Phase 3 study of Methamphetamine-dependence and Methamphetamine Abuse, sponsored by National Institute on Drug Abuse (NIDA).
- Recruiting
- Registry status
- Phase 3
- Development phase
- 360
- Enrollment target
- 11
- Study locations
NCT06233799: Recruiting Phase 3 study of Methamphetamine-dependence and Methamphetamine Abuse, sponsored by National Institute on Drug Abuse (NIDA).
NCT06233799 is a Phase 3 study of Methamphetamine-dependence and Methamphetamine Abuse that is actively recruiting participants, run by National Institute on Drug Abuse (NIDA). The registered enrollment target is 360 participants, above the 86-participant average among 18 other Methamphetamine-dependence trials with a reported enrollment target (319% higher). The trial reports 11 study locations across 10 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT06233799, a Phase 3 study of Methamphetamine-dependence and Methamphetamine Abuse, is actively recruiting participants, sponsored by National Institute on Drug Abuse (NIDA).
- RECRUITING
- Registry status
- Phase 3
- Development phase
- 360 participants
- Enrollment target
- 11
- Study locations
Study Summary
The primary objective of this study is to evaluate the efficacy of extended release naltrexone plus bupropion XL (XR-NTX/BUP-XL) compared to matched injectable and oral placebo (iPLB/oPLB) in reducing methamphetamine (MA) use in individuals with moderate or severe methamphetamine use disorder (MUD) seeking to stop or reduce MA use.
Primary Outcome
Participants will be administered four urine drug screen tests (two tests/week) during the evaluation period. (i.e., Weeks 11-12).
Conditions Studied
Interventions
- DRUG extended-release naltrexone (XR-NTX)
- DRUG extended release bupropion (BUP-XL) tablets (BUP-XL)
- DRUG iPLB
- DRUG oPLB
Study Locations (11)
California
- University of California Los Angeles - Los Angeles
- University of California at San Diego - San Diego
Arkansas
- University of Arkansas for Medical Sciences - Little Rock
Indiana
- Indiana University - Indianapolis
Kansas
- University of Kansas Medical Center - Kansas City
Minnesota
- University of Minnesota - Minneapolis
Oregon
- CODA - Portland
South Carolina
- MUSC/BHS - Pickens
Tennessee
- University of Tennessee - Memphis
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 360 participants |
| Start Date | 2024-07-01 |
| Est. Completion | 2027-04-30 |
| Phase | Phase 3 |
What NCT06233799 shows while recruiting
NCT06233799 is an interventional study that assigns participants to a tested intervention. The registered 360 participants enrollment target is mid-sized for trials with a published cap, above the 86-participant average among 18 other Methamphetamine-dependence trials with a reported enrollment target (319% higher).
The record links to 2 conditions, with Methamphetamine-dependence appearing as the primary indexed condition, and to 4 interventions - of which extended-release naltrexone (XR-NTX) is the first listed.
NCT06233799 lists 11 locations in 10 states (California, Arkansas, Indiana).
Frequently Asked Questions
What is clinical trial NCT06233799 about?
NCT06233799 is a clinical study titled "Trial of Naltrexone/Bupropion for the Treatment of Methamphetamine Use Disorder". The primary objective of this study is to evaluate the efficacy of extended release naltrexone plus bupropion XL (XR-NTX/BUP-XL) compared to matched injectable and oral placebo (iPLB/oPLB) in reducing methamphetamine (MA) use in individuals with moderate or severe methamphetamine use disorder (MUD) ...
What is the current status of trial NCT06233799?
This trial is currently recruiting. It is a Phase 3 study. The enrollment target is 360 participants. The study started on 2024-07-01. Estimated completion is 2027-04-30.
What conditions does trial NCT06233799 study?
This clinical trial studies the following conditions: Methamphetamine-dependence, Methamphetamine Abuse.
What interventions are being tested in trial NCT06233799?
The interventions under investigation include: extended-release naltrexone (XR-NTX) (DRUG), extended release bupropion (BUP-XL) tablets (BUP-XL) (DRUG), iPLB (DRUG), oPLB (DRUG).
Who is sponsoring clinical trial NCT06233799?
This trial is sponsored by National Institute on Drug Abuse (NIDA), which has 335 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06233799 being conducted?
This trial has 11 study locations across Arkansas, California, Indiana, Kansas, Minnesota. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Methamphetamine-dependence
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT06233799's enrollment target sits among peer trials
360 2nd of 18 the highest of 18 other Methamphetamine-dependence trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Methamphetamine-dependence trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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