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NCT02147392 · ClinicalTrials.gov registry record · Early Phase 1
Assessment of [11C]ER176 to Image Translocator Protein in Brain and Whole Body of Healthy People
A Early Phase 1 study, sponsored by National Institute of Mental Health (NIMH).
- Completed
- Registry status
- Early Phase 1
- Development phase
- 16
- Enrollment target
NCT02147392: Completed Early Phase 1 study, sponsored by National Institute of Mental Health (NIMH).
NCT02147392 is a Early Phase 1 study that has completed, run by National Institute of Mental Health (NIMH). The registered enrollment target is 16 participants, below the 53-participant average among 2,764 other Early Phase 1 trials with a reported enrollment target (70% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02147392, a Early Phase 1 study, has completed, sponsored by National Institute of Mental Health (NIMH).
- COMPLETED
- Registry status
- Early Phase 1
- Development phase
- 16 participants
- Enrollment target
Study Summary
Background: \- A protein called translocator protein may play a role in brain inflammation. Sometimes it is present at higher levels in the lungs than in the brain. Researchers want to see if a drug called \[11C\]ER176 can provide an image of this protein in the brain. Objective: \- To test the ability of a drug to image a protein, and test how it is distributed in the body. Eligibility: \- Healthy adults over age 18. Design: * Participants will be screened with medical history, physical exam, and blood and urine tests. * Participants will have a PET scan of the brain using \[11C\]ER176. It will be injected through an intravenous tube into 1-2 arm veins. A tube may also be put into an artery at the wrist or elbow. Some participants will also have a lung scan. * For the PET, participants will lie on a bed that slides in and out of a doughnut-shaped scanner. A plastic mask will be molded to their face and head. They may be wrapped with restraining sheets. The scan will last about 120 minutes. Blood may be taken during the scan. * Blood and urine will be taken before and after the scan. * During another visit, participants will have an MRI scan of the brain. Participants will lie on a table that slides in and out of a metal cylinder. A strong magnetic field and radio waves will take pictures of the brain. The scanner makes loud knocking noises. Participants will be given earplugs. * Some participants will have only a whole-body PET scan using \[11C\]ER176.
Interventions
- DRUG [11C]ER-176
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 16 participants |
| Start Date | 2014-05-14 |
| Est. Completion | 2016-06-16 |
| Phase | Early Phase 1 |
What the finished NCT02147392 record still lists
NCT02147392 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 16 participants, a relatively small participant target, below the 53-participant average among 2,764 other Early Phase 1 trials with a reported enrollment target (70% lower).
The record links to 0 conditions, and to 1 intervention - of which [11C]ER-176 is the first listed.
NCT02147392 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT02147392 about?
NCT02147392 is a clinical study titled "Assessment of [11C]ER176 to Image Translocator Protein in Brain and Whole Body of Healthy People". Background: \- A protein called translocator protein may play a role in brain inflammation. Sometimes it is present at higher levels in the lungs than in the brain. Researchers want to see if a drug called \[11C\]ER176 can provide an image of this protein in the brain. Objective: \- To test the a...
What is the current status of trial NCT02147392?
This trial is currently completed. It is a Early Phase 1 study. The enrollment target is 16 participants. The study started on 2014-05-14. Estimated completion is 2016-06-16.
What interventions are being tested in trial NCT02147392?
The interventions under investigation include: [11C]ER-176 (DRUG).
Who is sponsoring clinical trial NCT02147392?
This trial is sponsored by National Institute of Mental Health (NIMH), which has 343 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT02147392's enrollment target sits among peer trials
16 1370th of 2000 higher than 598 of 2,000 other Early Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Early Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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