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NCT05092971 · ClinicalTrials.gov registry record · NA
Identifying Decision Making Parameters in Healthy Volunteers and Anxiety Patients
A NA study, sponsored by National Institute of Mental Health (NIMH).
- Completed
- Registry status
- NA
- Development phase
- 51
- Enrollment target
NCT05092971: Completed NA study, sponsored by National Institute of Mental Health (NIMH).
NCT05092971 is a NA study that has completed, run by National Institute of Mental Health (NIMH). The registered enrollment target is 51 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (96% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT05092971, a NA study, has completed, sponsored by National Institute of Mental Health (NIMH).
- COMPLETED
- Registry status
- NA
- Development phase
- 51 participants
- Enrollment target
Study Summary
Background: Research has shown that anxiety affects more than feelings. It also affects behavior. Researchers want to learn how the brain and body respond to unexpected threats. They want to see if probable pleasant or unpleasant events change decisions. Objective: To better understand how changes in anxiety are associated with changes in decision-making. Eligibility: Adults aged 18-50 with generalized anxiety disorder, seasonal affective disorder, or panic disorder. Healthy volunteers are also needed. Design: Participants will be screened under protocol #01-M-0254. Participants will complete surveys about their anxiety, risk-taking, and curiosity. Participants will complete a computer task. They will be given different choices. They will make a choice. They will receive an unpleasant or pleasant stimulus based on their choice. They will repeat this task many times. Most participants will do the task in the clinic. The unpleasant stimulus will be electric shock and acoustic startle. They will receive electric shocks through electrodes placed on their arm or fingers. They may hear loud noises through headphones. Their eyeblinks will be recorded with electrodes placed under their eye. Their heart rate and skin conductance activity will be collected with electrodes as well. Some healthy volunteers will do the task during a functional magnetic resonance imaging scan. They will lie on a table that slides in and out of a scanner. A coil will be placed over their head. The unpleasant stimulus will be electric shock, given as stated above. The scanner will record their brain activity. Their breathing and pulse rate will be recorded as well. Participation will last for 3-4 hours.
Primary Outcome
Learning rate is a hyperparameter that quantifies the degree to which subjects update their beliefs in response to feedback. The outcome examined the difference in learning rate between experimental manipulation (condition) and population (healthy and anxiety subjects). During the multi-arm bandit task, participants choose from a set of choices and update their belief of the value of the choices based on prior choices with some choices having a higher probability of shock (punishment) than rewar
Interventions
- DEVICE Shock or startle device
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 51 participants |
| Start Date | 2022-03-03 |
| Est. Completion | 2022-07-28 |
| Phase | NA |
What the finished NCT05092971 record still lists
NCT05092971 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 51 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (96% lower).
The record links to 0 conditions, and to 1 intervention - of which Shock or startle device is the first listed.
NCT05092971 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT05092971 about?
NCT05092971 is a clinical study titled "Identifying Decision Making Parameters in Healthy Volunteers and Anxiety Patients". Background: Research has shown that anxiety affects more than feelings. It also affects behavior. Researchers want to learn how the brain and body respond to unexpected threats. They want to see if probable pleasant or unpleasant events change decisions. Objective: To better understand how change...
What is the current status of trial NCT05092971?
This trial is currently completed. It is a NA study. The enrollment target is 51 participants. The study started on 2022-03-03. Estimated completion is 2022-07-28.
What interventions are being tested in trial NCT05092971?
The interventions under investigation include: Shock or startle device (DEVICE).
Who is sponsoring clinical trial NCT05092971?
This trial is sponsored by National Institute of Mental Health (NIMH), which has 343 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT05092971's enrollment target sits among peer trials
51 1279th of 2000 higher than 722 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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