H. Lee Moffitt Cancer Center and Research Institute

502 total trials 82 currently recruiting 280 completed

H. Lee Moffitt Cancer Center and Research Institute sponsors 502 registered US clinical trials on ClinicalTrials.gov, 82 of them currently recruiting, and 280 completed. 5 of these trials are in Phase 3-4 (later-stage) and 335 in Phase 1-2 (earlier-stage). The most-studied condition in this pipeline is Prostate Cancer, with 12 trials.

Trial Pipeline

502 total, page 2 of 11

RECRUITING Phase 1

A First in Human Dose Escalation of Dendritic Cell Vaccine (DCV)

NCT05809752

RECRUITING NA

Support Through Remote Observation and Nutrition Guidance Program (STRONG-PCS)

NCT06001268

RECRUITING Phase 2

Itacitinib Pre-modulation in DLBCL Receiving CAR T Cell Therapy

NCT05757219

RECRUITING Phase 1

CalPeg for Newly Diagnosed Acute Lymphoblastic Leukemia (ALL)

NCT05581030

RECRUITING Early Phase 1

Adaptive Therapy of Vismodegib in Advanced Basal Cell Carcinoma

NCT05651828

RECRUITING

Outreach Core Activities

NCT05832177

RECRUITING

Evaluating Obesity-Mediated Mechanisms of Pancreatic Carcinogenesis in Minority Populations

NCT05687188

RECRUITING Phase 2

Luspatercept for Anemia in Lower Risk MDS or Non-proliferative MDS/MPN Neoplasms

NCT05732961

RECRUITING Phase 1

Remote Resistance Exercise Powering Survivors - Gastrointestinal Oncology

NCT05664178

RECRUITING Phase 1

CPX-351 in Combination With Gemtuzumab Ozogamicin in Newly Diagnosed AML

NCT05558124

RECRUITING Phase 2

Study of Sipuleucel-T With or Without Continuing New Hormonal Agents in Metastatic Prostate Cancer

NCT05751941

RECRUITING Phase 2

Genomically Guided Radiation Therapy in the Management of Triple Negative Breast Cancer

NCT05528133

RECRUITING

Using Biomarkers for Diagnosis, Risk Stratification of Post -Treatment Recurrence and Long-Term Surveillance of Lung Cancer

NCT05665504

RECRUITING Phase 2

Study of the Combination Dostarlimab With Niraparib In Patients With Penile Carcinoma

NCT05526989

RECRUITING Phase 2

Olaparib in Combination With Pembrolizumab for Advanced Uveal Melanoma

NCT05524935

RECRUITING Phase 1

DecipHER Trial - DC1 Tx for Early-Stage TNBC and ER Low Positive Breast Cancer

NCT05504707

RECRUITING Phase 1

Adoptive T Cell Therapy Following HER2-Pulsed Dendritic Cell Vaccine & Pepinemab /Trastuzumab in Patients w/ Metastatic HER2+ Breast Cancer

NCT05378464

RECRUITING Phase 2

Habitat Escalated Adaptive Therapy (HEAT), With Neoadjuvant Radiation for Soft Tissue Sarcoma

NCT05301283

RECRUITING Phase 1

Infusion of Autologous T Cells Engineered to Target FSH Receptor in Recurrent Ovarian Cancer

NCT05316129

RECRUITING Phase 1

Vyxeos Plus Gilteritinib in Relapsed or Refractory, FLT3-Mutated AML

NCT05024552

RECRUITING

Study of Screening Brain MRIs in Stage IV Breast Cancer

NCT05115474

RECRUITING Phase 1

Stereotactic Radiation & Abemaciclib in the Management of HR+/HER2- Breast Cancer Brain Metastases

NCT04923542

RECRUITING Early Phase 1

Using Aspirin to Improve Immunological Features of Ovarian Tumors

NCT05080946

RECRUITING Phase 2

Study of HER2 Directed Dendritic Cell (DC1) Vaccine + Weekly Paclitaxel, Trastuzumab & Pertuzumab

NCT05325632

RECRUITING Phase 2

Study of Afatinib in Advanced Cutaneous Squamous Cell Carcinoma

NCT05070403

RECRUITING Phase 2

Axitinib + Ipilimumab in Advanced Melanoma

NCT04996823

RECRUITING Early Phase 1

Adjuvant Therapy Based on Pathologic Response After Neoadjuvant Encorafenib Binimetinib in Melanoma

NCT04741997

RECRUITING Phase 1

Radiation Therapy Followed by Intrathecal Trastuzumab/Pertuzumab in HER2+ Breast Leptomeningeal Disease

NCT04588545

RECRUITING Phase 2

IL2 With Ipilimumab Followed by Nivolumab in Stage 3 or 4 Melanoma Patients

NCT04562129

RECRUITING

Generating Novel Therapeutic Strategies Based on Evolutionary Tumor Board

NCT04343365

RECRUITING

Using Radiogenomics to Predict Malignant Potential of Intraductal Papillary Mucinous Neoplasms of the Pancreas

NCT04275557

RECRUITING Phase 2

PSMA-PET Imaging for Detecting Early Metastatic Prostate Cancer in Men w/ High Decipher Test Scores

NCT03495427

ACTIVE NOT RECRUITING NA

NutritiOUs fRuIts and veggieS to Improve Health: A Culinary Medicine Intervention

NCT06926972

ACTIVE NOT RECRUITING NA

Physical Activity and Nutrition to Halt Elevated Risk in the Pancreas Interception Center

NCT06712797

ACTIVE NOT RECRUITING Phase 2

Adaptive Androgen Deprivation and Docetaxel in Metastatic Castration Sensitive Prostate Cancer

NCT06734130

ACTIVE NOT RECRUITING Phase 2

Study of IPMN Progression Prevention With Tocotrienol (SIPP-T3)

NCT06519097

ACTIVE NOT RECRUITING Phase 1

TBio-4101 and Pembro wi/ or w/o Chemo in Recurrent/Metastatic HNSCC

NCT06236425

ACTIVE NOT RECRUITING Phase 1

Study of CG0070 After Transurethral Resection in Patients With IR NMIBC

NCT06253845

ACTIVE NOT RECRUITING

Investigation of MP Pollution in the Human Respiratory System and Its Relationship to Lung Cancer

NCT06530615

ACTIVE NOT RECRUITING NA

Breast Cancer Survivors RESET (Reducing Weight and Elevated Stress Levels Using Educational and Behavioral Tools): A Pilot, Feasibility Study

NCT07101861

ACTIVE NOT RECRUITING Phase 2

Phase 2 Trial of Adaptive Radiotherapy Boost for HNSCC

NCT06137274

ACTIVE NOT RECRUITING

REFLECT: Reproductive Education and Fertility Links for Cancer Treatment

NCT06199726

ACTIVE NOT RECRUITING NA

The MONITOR Study: Remote Monitoring Of a Nutrition Intervention To Optimize Treatment Response

NCT06050395

ACTIVE NOT RECRUITING Phase 1

Intravesical Adoptive Cell Therapy w/ TIL for BCG Exposed High Grade NMIBC

NCT05768347

ACTIVE NOT RECRUITING NA

Senior Adult Hepatobiliary Prehab Study

NCT05921552

ACTIVE NOT RECRUITING NA

The ENHANCE Study: Exercise and Nutrition in Head And Neck CancEr Survivors

NCT05798780

ACTIVE NOT RECRUITING Phase 1

Clinical Trial of CD40L-Augmented TIL for Patients With EGFR, ALK, ROS1 or HER2-Driven NSCLC

NCT05681780

ACTIVE NOT RECRUITING NA

Exercise Prehabilitation Among Older Patients With Hematological Malignancies Preparing For CAR-T Cell Immunotherapy

NCT05763563

ACTIVE NOT RECRUITING NA

Support Through Remote Observation and Nutrition Guidance (STRONG) Program for Pancreatic Cancer Patients

NCT05675059

ACTIVE NOT RECRUITING NA

Enhancing Long-Term Smoking Abstinence Among Cervical Cancer Survivors (Project ACCESS)

NCT05645146

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Phase Distribution

PhaseTrial count
Phase 1 167
Phase 2 168
Phase 3 3
Phase 4 2

What the Pipeline for H. Lee Moffitt Cancer Center and Research Institute Shows

According to the ClinicalTrials.gov registry, H. Lee Moffitt Cancer Center and Research Institute is linked to 502 US clinical trials across every stage of research activity. Of those, 82 studies are currently recruiting, about 16% of the sponsor's indexed portfolio, and 280 are already marked complete, representing roughly 56% of the total.

The phase mix for H. Lee Moffitt Cancer Center and Research Institute reports 5 late-stage studies (Phase 3 and Phase 4 combined) and 335 earlier-phase studies (Phase 1 and Phase 2).

The top therapeutic focus area indexed for H. Lee Moffitt Cancer Center and Research Institute is Prostate Cancer with 12 linked trials, and 9 other condition areas appear in the top list above.

How to read these pipeline numbers

Recruiting share is one of the more practical signals here: it reflects how much of a sponsor's research is presently open to new participants, while the completed share indicates the depth of finished work that has already contributed registry results. Both counts come directly from the public ClinicalTrials.gov dataset and are refreshed on the registry side; this page mirrors the latest data pull without altering it.

A portfolio weighted toward Phase 3 usually reflects an organization advancing candidates toward regulatory review, where the research centers on comparative efficacy and broader safety across larger populations. A heavier Phase 1 and Phase 2 tilt generally indicates exploratory work, safety, dosing, and early signal detection, and is common among research-forward sponsors that seed many early programs. Phase 4 entries, when present, track interventions already in real-world use and typically focus on long-term safety, effectiveness across subgroups, or formulation comparisons.

That distribution is a quick read of where the organization concentrates its research attention; it does not imply product availability, market share, or any clinical endorsement. All numbers on this page come from ClinicalTrials.gov maintained by the National Library of Medicine, and counts can shift as new studies are registered or existing ones update their status. This information is provided for reference and educational purposes only, not as medical, investment, or regulatory advice, verify current details directly with ClinicalTrials.gov before relying on any figure here.

Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial from this sponsor, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.