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ClinicalTrials.gov 12 recruiting now official registry

Urothelial Cancer clinical trials

12 of 26 indexed Urothelial Cancer trials are currently recruiting.

26 US clinical trials · 12 currently recruiting

Urothelial Cancer is the subject of 26 registered US clinical trials on ClinicalTrials.gov, 12 of them currently open to new participants. 6 are in Phase 3-4 (later-stage) and 16 in Phase 1-2 (earlier-stage). The most active sponsor is National Cancer Institute (NCI), running 3 of these trials.

The research picture

Urothelial Cancer has 26 registered US clinical trials, 12 of them open to new participants right now, about 46% of the total.

12
recruiting participants now
46%
of trials open to enrollment
6
in Phase 3–4 (later-stage)
3
top sponsor: National Cancer Institute (NCI)
Phase 19Phase 27Phase 36

Active & Recent Trials

26 total, page 1 of 1

RECRUITING 1,100 participants

A Multi-Center Natural History of Urothelial Cancer and Rare Genitourinary Tract Malignancies

National Cancer Institute (NCI)

NCT04923178

RECRUITING Phase 2 630 participants

Study of Datopotamab Deruxtecan Plus Carboplatin or Cisplatin Versus Gemcitabine Plus Carboplatin or Cisplatin in Participants With Locally Advanced or Metastatic Urothelial Carcinoma

Daiichi Sankyo

NCT07129993

RECRUITING 500 participants

Evaluation of Non-Invasive Assays for the Detection of Urothelial Cancer

Lahey Clinic

NCT00872495

RECRUITING 500 participants

Care of the Urothelial Cancer Patient and Prospective Procurement of Urothelial Cancer Tissue

National Cancer Institute (NCI)

NCT02379429

RECRUITING Phase 2 470 participants

Phase 2/3 Trial of Izalontamab Brengitecan vs Platinum-based Chemotherapy for Metastatic Urothelial Cancer With Disease Progression on or After Immunotherapy

Bristol-Myers Squibb

NCT07106762

RECRUITING Phase 2 454 participants

Study of Dato-DXd as Monotherapy and in Combination With Anti-cancer Agents in Patients With Advanced Solid Tumours (TROPION-PanTumor03)

AstraZeneca

NCT05489211

RECRUITING Phase 1 355 participants

BEACON-1: Study of AVZO-103 as a Single Agent and in Combination Therapy in Patients With Locally Advanced or Metastatic Urothelial Cancer or Other Solid Tumors (AVZO-103-1001)

Avenzo Therapeutics

NCT07193511

RECRUITING Phase 1 200 participants

A Study of STRO-004 in Adults With Refractory/Recurrent Metastatic Cancer

Sutro Biopharma

NCT07227168

RECRUITING Phase 1 106 participants

Sacituzumab Govitecan Plus EV in Metastatic UC

Dana-Farber Cancer Institute

NCT04724018

RECRUITING Phase 1 100 participants

Bintrafusp Alfa (M7824) and PDS01ADC Alone and in Combination With Stereotactic Body Radiation Therapy (SBRT) in Adults With Metastatic Non-Prostate Genitourinary Malignancies

National Cancer Institute (NCI)

NCT04235777

RECRUITING Phase 2 72 participants

Anti-PD-1 mAb Plus Metabolic Modulator in Solid Tumor Malignancies

Dan Zandberg

NCT04114136

RECRUITING Phase 1 70 participants

SLV-154 Treatment of Metastatic Solid Tumors

Solve Therapeutics

NCT06771219

ACTIVE NOT RECRUITING 3,519 participants

A Genotype-Phenotype Urothelial Cancer Registry

Memorial Sloan Kettering Cancer Center

NCT00902590

ACTIVE NOT RECRUITING Phase 3 1,314 participants

Study of Nivolumab in Combination With Ipilimumab or Standard of Care Chemotherapy Compared to the Standard of Care Chemotherapy Alone in Treatment of Participants With Untreated Inoperable or Metastatic Urothelial Cancer

Bristol-Myers Squibb

NCT03036098

ACTIVE NOT RECRUITING Phase 3 1,126 participants

Study of MEDI4736 (Durvalumab) With or Without Tremelimumab Versus Standard of Care Chemotherapy in Urothelial Cancer

AstraZeneca

NCT02516241

ACTIVE NOT RECRUITING Phase 3 886 participants

Enfortumab Vedotin and Pembrolizumab vs. Chemotherapy Alone in Untreated Locally Advanced or Metastatic Urothelial Cancer

Astellas Pharma Global Development

NCT04223856

ACTIVE NOT RECRUITING Phase 3 629 participants

A Study of Erdafitinib Compared With Vinflunine or Docetaxel or Pembrolizumab in Participants With Advanced Urothelial Cancer and Selected Fibroblast Growth Factor Receptor (FGFR) Gene Aberrations

Janssen Research & Development

NCT03390504

ACTIVE NOT RECRUITING Phase 1 348 participants

A Study of Enfortumab Vedotin Alone or With Other Therapies for Treatment of Urothelial Cancer

Astellas Pharma Global Development

NCT03288545

ACTIVE NOT RECRUITING Phase 1 288 participants

Study BT5528-100 in Patients With Advanced Solid Tumors Associated With EphA2 Expression

BicycleTx Limited

NCT04180371

ACTIVE NOT RECRUITING Phase 2 239 participants

An Efficacy and Safety Study of Erdafitinib (JNJ-42756493) in Participants With Urothelial Cancer

Janssen Research & Development

NCT02365597

ACTIVE NOT RECRUITING Phase 2 204 participants

A Study Evaluating Different Immunotherapies (LAG-3 and PD-1 With or Without TIGIT, Compared to PD-L1 Alone) in Participants With Untreated Locally Advanced Metastatic Urothelial Cancer

Hoffmann-La Roche

NCT05645692

ACTIVE NOT RECRUITING Phase 1 144 participants

A Study of ADRX-0706 in Select Advanced Solid Tumors

Adcentrx Therapeutics

NCT06036121

ACTIVE NOT RECRUITING Phase 1 120 participants

ADP-A2M4CD8 as Monotherapy or in Combination With Either Nivolumab or Pembrolizumab in HLA-A2+ Subjects With MAGE-A4 Positive Tumors (SURPASS)

Uswm CT

NCT04044859

ACTIVE NOT RECRUITING Phase 3 68 participants

Continued Access Study for Participants Deriving Benefit in Pfizer-Sponsored Avelumab Parent Studies That Are Closing

Pfizer

NCT05059522

COMPLETED Phase 3 700 participants

A Study Of Avelumab In Patients With Locally Advanced Or Metastatic Urothelial Cancer (JAVELIN Bladder 100)

Pfizer

NCT02603432

COMPLETED Phase 2 219 participants

A Study of Enfortumab Vedotin for Patients With Locally Advanced or Metastatic Urothelial Bladder Cancer

Astellas Pharma

NCT03219333

Phase Distribution

PhaseTrial count
Phase 1 9
Phase 2 7
Phase 3 6

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Urothelial Cancer Trial Landscape

26 indexed Urothelial Cancer studies · 12 recruiting (46%).

Phase mix: 6 late (III/IV) vs 16 early (I/II).

Top sponsor: National Cancer Institute (NCI) (3 trials), 9 others listed. 26 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Urothelial Cancer?

PlainTrial tracks 26 US clinical trials for Urothelial Cancer, of which 12 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Urothelial Cancer?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.