Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

COMPLETED Phase 3

A Study Of Avelumab In Patients With Locally Advanced Or Metastatic Urothelial Cancer (JAVELIN Bladder 100)

NCT02603432 · View on ClinicalTrials.gov ↗

Study Summary

The main purpose of this study is to compare maintenance treatment with avelumab plus best supportive care (BSC) with BSC alone, to determine if avelumab has an effect on survival in patients with locally advanced or metastatic urothelial cancer that did not worsen during or following completion of first-line chemotherapy.

Conditions Studied

Interventions

  • BIOLOGICAL Avelumab
  • OTHER Best Supportive Care
  • BIOLOGICAL Following the planned interim analysis for this study: Avelumab

Study Locations (20)

Colorado

  • Anschutz Cancer Center Pavilion Pharmacy — Aurora
  • University of Colorado Cancer Center — Aurora
  • University of Colorado Denver, CTO (CTRC) — Aurora
  • University of Colorado Hospital - Anschutz Inpatient Pavilion (AIP) — Aurora
  • University of Colorado Hospital - Anschutz Outpatient Pavilion (AOP) — Aurora

Ohio

  • Cleveland Clinic Taussing Cancer Center — Cleveland
  • Cleveland Clinic Taussing Cancer Center — Cleveland
  • Cleveland Clinic Foundation — Cleveland
  • Cleveland Clinic Taussing Cancer Center — Cleveland

Washington

  • Seattle Cancer Care Alliance — Seattle
  • Seattle Cancer Care Alliance — Seattle
  • University of Washington Medical Center — Seattle

Connecticut

  • Smilow Cancer Hospital at Yale New Haven — New Haven
  • Smilow Cancer Hospital at Yale-New Haven — New Haven

Minnesota

  • University of Minnesota Medical Center — Minneapolis
  • University of Minnesota — Minneapolis

Virginia

  • Inova Schar Cancer Institute Infusion Pharmacy — Fairfax
  • Inova Schar Cancer Institute — Fairfax

Massachusetts

  • Massachusetts General Hospital — Boston

Buenos Aires

  • Centro de Investigacion Pergamino S.A. — Pergamino

Trial Details

FieldValue
Enrollment Target 700 participants
Start Date 2016-04-25
Est. Completion 2023-03-28
Phase Phase 3

Sponsor

Pfizer

769 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT02603432

The ClinicalTrials.gov registry entry for NCT02603432 describes a study currently listed as completed. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 700 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Pfizer, which has 769 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Urothelial Cancer appearing as the primary indexed condition, and to 3 interventions — of which Avelumab is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT02603432 reports 20 study locations spanning 8 distinct geographic areas — top geographies include Colorado, Ohio, Washington. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT02603432 about?

NCT02603432 is a clinical study titled "A Study Of Avelumab In Patients With Locally Advanced Or Metastatic Urothelial Cancer (JAVELIN Bladder 100)". The main purpose of this study is to compare maintenance treatment with avelumab plus best supportive care (BSC) with BSC alone, to determine if avelumab has an effect on survival in patients with locally advanced or metastatic urothelial cancer that did not worsen during or following completion of ...

What is the current status of trial NCT02603432?

This trial is currently completed. It is a Phase 3 study. The enrollment target is 700 participants. The study started on 2016-04-25. Estimated completion is 2023-03-28.

What conditions does trial NCT02603432 study?

This clinical trial studies the following conditions: Urothelial Cancer. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT02603432?

The interventions under investigation include: Avelumab (BIOLOGICAL), Best Supportive Care (OTHER), Following the planned interim analysis for this study: Avelumab (BIOLOGICAL). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT02603432?

This trial is sponsored by Pfizer, which has 769 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT02603432 being conducted?

This trial has 20 study locations across Colorado, Connecticut, Massachusetts, Minnesota, Ohio. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial