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NCT02516241 · ClinicalTrials.gov registry record · Phase 3
Study of MEDI4736 (Durvalumab) With or Without Tremelimumab Versus Standard of Care Chemotherapy in Urothelial Cancer
A Phase 3 study of Urothelial Cancer, sponsored by AstraZeneca.
- Active
- Registry status
- Phase 3
- Development phase
- 1,126
- Enrollment target
- 20
- Study locations
NCT02516241: Active Phase 3 study of Urothelial Cancer, sponsored by AstraZeneca.
NCT02516241 is a Phase 3 study of Urothelial Cancer that is active but no longer recruiting, run by AstraZeneca. The registered enrollment target is 1,126 participants, above the 529-participant average among 25 other Urothelial Cancer trials with a reported enrollment target (113% higher). The trial reports 20 study locations across 13 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT02516241, a Phase 3 study of Urothelial Cancer, is active but no longer recruiting, sponsored by AstraZeneca.
- ACTIVE NOT RECRUITING
- Registry status
- Phase 3
- Development phase
- 1,126 participants
- Enrollment target
- 20
- Study locations
Study Summary
A Phase III, Randomized, Open-Label, Controlled, Multi-Center, Global Study of First-Line MEDI4736 (Durvalumab) Monotherapy and MEDI4736 (Durvalumab) in Combination with Tremelimumab Versus Standard of Care Chemotherapy in Patients with Stage IV Urothelial Cancer
Primary Outcome
The OS was defined as the time from the date of randomization until death due to any cause (ie, date of death or censoring - date of randomization + 1). Any participant not known to have died at the time of analysis were censored based on the last recorded date on which the participant was known to be alive. Median OS was calculated using the Kaplan-Meier technique.
Conditions Studied
Interventions
- DRUG Carboplatin
- DRUG Cisplatin
- DRUG Gemcitabine
- DRUG Tremelimumab
- DRUG MEDI4736 (Durvalumab)
Study Locations (20)
Other
- Research Site - Box Hill
- Research Site - Elizabeth Vale
- Research Site - Macquarie University
- Research Site - St Leonards
California
- Research Site - Los Angeles
- Research Site - Stanford
Michigan
- Research Site - Ann Arbor
- Research Site - Detroit
New York
- Research Site - New York
- Research Site - New York
Tennessee
- Research Site - Memphis
- Research Site - Nashville
Colorado
- Research Site - Aurora
Connecticut
- Research Site - New Haven
Florida
- Research Site - Tampa
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 1,126 participants |
| Start Date | 2015-11-02 |
| Est. Completion | 2026-12-31 |
| Phase | Phase 3 |
What the registry record for NCT02516241 still lists
NCT02516241 is an interventional study that assigns participants to a tested intervention. Its 1,126 participants enrollment target places it among the larger protocols in the corpus, above the 529-participant average among 25 other Urothelial Cancer trials with a reported enrollment target (113% higher).
The record links to 1 condition, with Urothelial Cancer appearing as the primary indexed condition, and to 5 interventions - of which Carboplatin is the first listed.
NCT02516241 names 20 study sites across 13 states, led by Other, California, Michigan.
Frequently Asked Questions
What is clinical trial NCT02516241 about?
NCT02516241 is a clinical study titled "Study of MEDI4736 (Durvalumab) With or Without Tremelimumab Versus Standard of Care Chemotherapy in Urothelial Cancer". A Phase III, Randomized, Open-Label, Controlled, Multi-Center, Global Study of First-Line MEDI4736 (Durvalumab) Monotherapy and MEDI4736 (Durvalumab) in Combination with Tremelimumab Versus Standard of Care Chemotherapy in Patients with Stage IV Urothelial Cancer
What is the current status of trial NCT02516241?
This trial is currently active not recruiting. It is a Phase 3 study. The enrollment target is 1,126 participants. The study started on 2015-11-02. Estimated completion is 2026-12-31.
What conditions does trial NCT02516241 study?
This clinical trial studies the following conditions: Urothelial Cancer.
What interventions are being tested in trial NCT02516241?
The interventions under investigation include: Carboplatin (DRUG), Cisplatin (DRUG), Gemcitabine (DRUG), Tremelimumab (DRUG), MEDI4736 (Durvalumab) (DRUG).
Who is sponsoring clinical trial NCT02516241?
This trial is sponsored by AstraZeneca, which has 1,285 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT02516241 being conducted?
This trial has 20 study locations across California, Colorado, Connecticut, Florida, Georgia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Urothelial Cancer
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT02516241's enrollment target sits among peer trials
1,126 3rd of 25 higher than 23 of 25 other Urothelial Cancer trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Urothelial Cancer trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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