Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
A Research Study to See How Well CagriSema Compared to Semaglutide, Cagrilintide and Placebo Lowers Blood Sugar and Body Weight in People With Type 2 Diabetes Treated With Metformin With or Without an SGLT2 Inhibitor
NCT06065540 · View on ClinicalTrials.gov ↗
Study Summary
The study will look at how well CagriSema helps people lower their blood sugar and body weight. CagriSema is a new weekly medicine that combines two medicines called semaglutide and cagrilintide. CagriSema will be compared to the two medicines semaglutide and cagrilintide, when they are taken alone. CagriSema will also be compared to a "dummy" medicine without any active ingredient. The study will be done in participants who have type 2 diabetes. Participants will take the study medicine together with the current diabetes medicine (metformin with or without an SGLT2 inhibitor).
Conditions Studied
Interventions
- DRUG Semaglutide
- DRUG Cagrilintide
- DRUG Placebo cagrilintide
- DRUG Placebo semaglutide
Study Locations (20)
California
- Velocity Clinical Res-Banning — Banning
- Velocity Clin Res-Chula Vista — Chula Vista
- John Muir Physicians Network — Concord
- Headlands Research California, LLC — Escondido
- Velocity Clin Res Gardena — Gardena
- Velocity Clin Res San Diego — La Mesa
- Loma Linda Univ Hlth Cr Endo — Loma Linda
- Facey Medical Foundation — Mission Hills
- Desert Oasis Hlthcr Med Group — Palm Springs
- Desert Oasis Hlthcr Med Group — Palm Springs
- Velocity Clin Res- San Bern — San Bernardino
- Linda Vista Health Care Ctr — San Diego
- Velocity Clin Res Santa Ana — Santa Ana
- Premier Medical Center, Inc. — Toluca Lake
Alabama
- Synexus Clin Res-Birmingham — Birmingham
- Univ of Alabama_Birmingham — Birmingham
- Cahaba Research — Pelham
Arizona
- Velocity Clinical Research-Phoenix — Phoenix
- Synexus Rsch /Cnt Phnx Med C — Phoenix
Arkansas
- Arkansas Clinical Research — Little Rock
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 2,734 participants |
| Start Date | 2023-09-27 |
| Est. Completion | 2026-01-06 |
| Phase | Phase 3 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06065540
The ClinicalTrials.gov registry entry for NCT06065540 describes a study currently listed as completed. It is categorized as Phase 3, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 2,734 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Novo Nordisk A/S, which has 189 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 1 condition, with Type 2 Diabetes Mellitus appearing as the primary indexed condition, and to 4 interventions — of which Semaglutide is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT06065540 reports 20 study locations spanning 4 distinct geographic areas — top geographies include California, Alabama, Arizona. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT06065540 about?
NCT06065540 is a clinical study titled "A Research Study to See How Well CagriSema Compared to Semaglutide, Cagrilintide and Placebo Lowers Blood Sugar and Body Weight in People With Type 2 Diabetes Treated With Metformin With or Without an SGLT2 Inhibitor". The study will look at how well CagriSema helps people lower their blood sugar and body weight. CagriSema is a new weekly medicine that combines two medicines called semaglutide and cagrilintide. CagriSema will be compared to the two medicines semaglutide and cagrilintide, when they are taken alone....
What is the current status of trial NCT06065540?
This trial is currently completed. It is a Phase 3 study. The enrollment target is 2,734 participants. The study started on 2023-09-27. Estimated completion is 2026-01-06.
What conditions does trial NCT06065540 study?
This clinical trial studies the following conditions: Type 2 Diabetes Mellitus. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT06065540?
The interventions under investigation include: Semaglutide (DRUG), Cagrilintide (DRUG), Placebo cagrilintide (DRUG), Placebo semaglutide (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT06065540?
This trial is sponsored by Novo Nordisk A/S, which has 189 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT06065540 being conducted?
This trial has 20 study locations across Alabama, Arizona, Arkansas, California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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