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RECRUITING Phase 2

A Study to Compare Different Doses of RO7795081 With a Placebo or Semaglutide in People With Type 2 Diabetes

NCT07112872 · View on ClinicalTrials.gov ↗

Study Summary

This multicenter, randomized, double-blind, placebo- and open-label active comparator-controlled, parallel-group, dose-range-finding, Phase II study aims to evaluate the efficacy, tolerability, and safety of RO7795081 for glycemic control in adult participants with Type 2 diabetes mellitus (T2D).

Conditions Studied

Interventions

  • DRUG Placebo
  • DRUG Semaglutide
  • DRUG RO7795081

Study Locations (20)

California

  • Orange County Research Center — Lake Forest
  • Prospective Research Innovations Inc. — Rancho Cucamonga
  • Encompass Clinical Research — Spring Valley

Florida

  • K2 Medical Research South Orlando, LLC — Clermont
  • Center for Diabetes, Obesity and Metabolism Inc — Pembroke Pines

North Carolina

  • Accellacare of Piedmont Healthcare — Statesville
  • Accellacare of Wilmington, LLC — Wilmington

Tennessee

  • Alliance for Multispecialty Research. LLC — Knoxville
  • Clinical Research Associates — Nashville

Texas

  • Texas Diabetes & Endocrinology, P.A. — Austin
  • Apex Mobile Clinical Research — Bellaire

Arizona

  • Arizona Liver Health - Tucson — Tucson

Connecticut

  • Chase Medical Research — Waterbury

District of Columbia

  • Emerson Clinical Research Institute — Washington D.C.

Trial Details

FieldValue
Enrollment Target 240 participants
Start Date 2025-08-19
Est. Completion 2027-02-08
Phase Phase 2

Sponsor

Hoffmann-La Roche

758 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT07112872

The ClinicalTrials.gov registry entry for NCT07112872 describes a study currently listed as recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 240 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Hoffmann-La Roche, which has 758 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Type 2 Diabetes Mellitus appearing as the primary indexed condition, and to 3 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT07112872 reports 20 study locations spanning 14 distinct geographic areas — top geographies include California, Florida, North Carolina. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT07112872 about?

NCT07112872 is a clinical study titled "A Study to Compare Different Doses of RO7795081 With a Placebo or Semaglutide in People With Type 2 Diabetes". This multicenter, randomized, double-blind, placebo- and open-label active comparator-controlled, parallel-group, dose-range-finding, Phase II study aims to evaluate the efficacy, tolerability, and safety of RO7795081 for glycemic control in adult participants with Type 2 diabetes mellitus (T2D).

What is the current status of trial NCT07112872?

This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 240 participants. The study started on 2025-08-19. Estimated completion is 2027-02-08.

What conditions does trial NCT07112872 study?

This clinical trial studies the following conditions: Type 2 Diabetes Mellitus. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT07112872?

The interventions under investigation include: Placebo (DRUG), Semaglutide (DRUG), RO7795081 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT07112872?

This trial is sponsored by Hoffmann-La Roche, which has 758 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT07112872 being conducted?

This trial has 20 study locations across Arizona, California, Connecticut, District of Columbia, Florida. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial