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NCT06524960 · ClinicalTrials.gov registry record · Phase 1
Denosumab for Type 1 Diabetes
A Phase 1 study of Type 1 Diabetes, sponsored by City of Hope Medical Center.
- Recruiting
- Registry status
- Phase 1
- Development phase
- 45
- Enrollment target
- 3
- Study locations
NCT06524960 is a Phase 1 study of Type 1 Diabetes that is actively recruiting participants, run by City of Hope Medical Center. The registered enrollment target is 45 participants, below the 824-participant average among 178 other Type 1 Diabetes trials with a reported enrollment target (95% lower). The trial reports 3 study locations across 3 states.
The verdict
NCT06524960, a Phase 1 study of Type 1 Diabetes, is actively recruiting participants, sponsored by City of Hope Medical Center.
- RECRUITING
- Registry status
- Phase 1
- Development phase
- 45 participants
- Enrollment target
- 3
- Study locations
Study Summary
Type 1 diabetes (T1D) arises from abnormal immune cell-mediated injury to beta cells that make insulin. The injured beta cells can then no longer make the needed amount of insulin to stay healthy. However, in the early stages of T1D, some beta cells are still alive and functioning. Treatment to protect the beta cells against injury at this time could slow the progress of disease. Denosumab is an approved treatment for osteoporosis (a disease that thins and weakens the bones), high blood calcium levels, bone cancer, and other bone problems in patients who have cancer. The research team has found that the bone pathway that denosumab works on to treat these bone conditions also has effects on the health of the beta cells. Lab studies suggest that denosumab may protect and/or increase the number of beta cells and improve how well they work. This study will test whether denosumab is safe and improves beta cell function and blood sugar control in people with early T1D.
Conditions Studied
Interventions
- OTHER Placebo
- DRUG Denosumab
Study Locations (3)
Alabama
- University of Alabama at Birmingham - Birmingham
California
- City of Hope Medical Center - Duarte
Indiana
- Indiana University - Indianapolis
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 45 participants |
| Start Date | 2024-09-03 |
| Est. Completion | 2027-10-11 |
| Phase | Phase 1 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT06524960
The ClinicalTrials.gov registry entry for NCT06524960 describes a study currently listed as recruiting, categorized as Phase 1. The registered enrollment target is 45 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 824-participant average among 178 other Type 1 Diabetes trials with a reported enrollment target (95% lower). The listed sponsor is City of Hope Medical Center, which has 582 total studies on file at ClinicalTrials.gov.
The record links to 1 condition, with Type 1 Diabetes appearing as the primary indexed condition, and to 2 interventions - of which Placebo is the first listed.
NCT06524960 reports 3 study locations spanning 3 distinct geographic areas - top geographies include Alabama, California, Indiana.
Frequently Asked Questions
What is clinical trial NCT06524960 about?
NCT06524960 is a clinical study titled "Denosumab for Type 1 Diabetes". Type 1 diabetes (T1D) arises from abnormal immune cell-mediated injury to beta cells that make insulin. The injured beta cells can then no longer make the needed amount of insulin to stay healthy. However, in the early stages of T1D, some beta cells are still alive and functioning. Treatment to prot...
What is the current status of trial NCT06524960?
This trial is currently recruiting. It is a Phase 1 study. The enrollment target is 45 participants. The study started on 2024-09-03. Estimated completion is 2027-10-11.
What conditions does trial NCT06524960 study?
This clinical trial studies the following conditions: Type 1 Diabetes.
What interventions are being tested in trial NCT06524960?
The interventions under investigation include: Placebo (OTHER), Denosumab (DRUG).
Who is sponsoring clinical trial NCT06524960?
This trial is sponsored by City of Hope Medical Center, which has 582 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT06524960 being conducted?
This trial has 3 study locations across Alabama, California, Indiana. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Related
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