Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.

RECRUITING Phase 2

SAFety and Efficacy of Human Anti-thymocyte ImmunoGlobUlin SAB-142 ARresting Progression of Type 1 Diabetes

NCT07187531 · View on ClinicalTrials.gov ↗

Study Summary

This is a Phase 2b, investigator- and participant-blinded, placebo-controlled, parallel-arm study to evaluate the efficacy, safety and tolerability of SAB 142 in patients with Stage 3 New Onset of Type 1 Diabetes (NOT1D).

Conditions Studied

Interventions

  • OTHER Placebo
  • DRUG High Dose SAB-142
  • DRUG Low Dose SAB-142

Study Locations (20)

Other

  • Queensland Children's Hospital — Brisbane
  • Government of Western Australia - Child and Adolescent Health Service - Perth Children's Hospital — Nedlands
  • The Royal Children's Hospital Melbourne — Parkville

Florida

  • University of Florida College of Medicine — Gainesville
  • University of Miami - Gables One Tower — Miami

Texas

  • Cook Children's Medical Center — Fort Worth
  • Texas Children's Hospital - Clinical Care Center - Pediatric Renal Clinic — Houston

Washington

  • Benaroya Research Institute at Virginia Mason — Seattle
  • Mary Bridge Children's Outpatient Center - Tacoma — Tacoma

California

  • University of California San Francisco Benioff Children's Hospital — San Francisco

Colorado

  • University of Colorado - Barbara Davis Center for Diabetes — Aurora

Georgia

  • Children's Healthcare of Atlanta (CHOA) - Center for Advanced Pediatrics — Atlanta

Indiana

  • IUH - Riley Hospital for Children - Riley Outpatient Center - Pediatric Diabetes & Endocrinology — Indianapolis

Trial Details

FieldValue
Enrollment Target 159 participants
Start Date 2025-11-25
Est. Completion 2028-12
Phase Phase 2

Sponsor

SAb Biotherapeutics

3 total trials

Interested in This Trial?

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT07187531

The ClinicalTrials.gov registry entry for NCT07187531 describes a study currently listed as recruiting. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 159 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is SAb Biotherapeutics, which has 3 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Type 1 Diabetes appearing as the primary indexed condition, and to 3 interventions — of which Placebo is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT07187531 reports 20 study locations spanning 15 distinct geographic areas — top geographies include Other, Florida, Texas. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT07187531 about?

NCT07187531 is a clinical study titled "SAFety and Efficacy of Human Anti-thymocyte ImmunoGlobUlin SAB-142 ARresting Progression of Type 1 Diabetes". This is a Phase 2b, investigator- and participant-blinded, placebo-controlled, parallel-arm study to evaluate the efficacy, safety and tolerability of SAB 142 in patients with Stage 3 New Onset of Type 1 Diabetes (NOT1D).

What is the current status of trial NCT07187531?

This trial is currently recruiting. It is a Phase 2 study. The enrollment target is 159 participants. The study started on 2025-11-25. Estimated completion is 2028-12.

What conditions does trial NCT07187531 study?

This clinical trial studies the following conditions: Type 1 Diabetes. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT07187531?

The interventions under investigation include: Placebo (OTHER), High Dose SAB-142 (DRUG), Low Dose SAB-142 (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT07187531?

This trial is sponsored by SAb Biotherapeutics, which has 3 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT07187531 being conducted?

This trial has 20 study locations across California, Colorado, Florida, Georgia, Indiana. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial