Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT03379220 · ClinicalTrials.gov registry record
Spreading Depolarizations in Traumatic Brain Injury
A clinical trial of Traumatic Brain Injury, sponsored by University of Cincinnati.
- Completed
- Registry status
- 147
- Enrollment target
- 7
- Study locations
NCT03379220: Completed study of Traumatic Brain Injury, sponsored by University of Cincinnati.
NCT03379220 is a study of Traumatic Brain Injury that has completed, run by University of Cincinnati. The registered enrollment target is 147 participants, below the 276-participant average among 171 other Traumatic Brain Injury trials with a reported enrollment target (47% lower). The trial reports 7 study locations across 6 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT03379220, a study of Traumatic Brain Injury, has completed, sponsored by University of Cincinnati.
- COMPLETED
- Registry status
- 147 participants
- Enrollment target
- 7
- Study locations
Study Summary
This research aims to extend the application of spreading depolarization monitoring to non-surgical TBI patients, using intraparenchymal electrode arrays and scalp electroencephalography to detect depolarizations and develop less invasive monitoring methods.
Primary Outcome
Glasgow Outcome Scale- Extended (GOS-E) is an ordinal global scale for functional outcome that rates patient status into one of eight categories, with higher scores representing better recovery: Dead (1), Vegetative State (2), Lower Severe Disability (3), Upper Severe Disability (4), Lower Moderate Disability (5), Upper Moderate Disability (6), Lower Good Recovery (7), and Upper Good Recovery (8).
Conditions Studied
Study Locations (7)
Pennsylvania
- University of Pennsylvania - Philadelphia
- University of Pittsburgh - Pittsburgh
California
- University of California San Francisco - San Francisco
Florida
- University of Miami - Miami
Massachusetts
- Massachusetts General Hospital - Boston
Ohio
- University of Cincinnati - Cincinnati
Texas
- Baylor College of Medicine - Houston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 147 participants |
| Start Date | 2017-03-28 |
| Est. Completion | 2022-06-15 |
What the finished NCT03379220 record still lists
NCT03379220 is an observational study that tracks outcomes without assigning an intervention. The registered 147 participants enrollment target is mid-sized for trials with a published cap, below the 276-participant average among 171 other Traumatic Brain Injury trials with a reported enrollment target (47% lower).
The record links to 1 condition, with Traumatic Brain Injury appearing as the primary indexed condition, and to 0 interventions.
NCT03379220 lists 7 locations in 6 states (Pennsylvania, California, Florida).
Frequently Asked Questions
What is clinical trial NCT03379220 about?
NCT03379220 is a clinical study titled "Spreading Depolarizations in Traumatic Brain Injury". This research aims to extend the application of spreading depolarization monitoring to non-surgical TBI patients, using intraparenchymal electrode arrays and scalp electroencephalography to detect depolarizations and develop less invasive monitoring methods.
What is the current status of trial NCT03379220?
This trial is currently completed. The enrollment target is 147 participants. The study started on 2017-03-28. Estimated completion is 2022-06-15.
What conditions does trial NCT03379220 study?
This clinical trial studies the following conditions: Traumatic Brain Injury.
Who is sponsoring clinical trial NCT03379220?
This trial is sponsored by University of Cincinnati, which has 245 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT03379220 being conducted?
This trial has 7 study locations across California, Florida, Massachusetts, Ohio, Pennsylvania. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Traumatic Brain Injury
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT03379220's enrollment target sits among peer trials
147 48th of 171 higher than 124 of 171 other Traumatic Brain Injury trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Traumatic Brain Injury trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
tPBM in Older Adults With Traumatic Brain Injury
RECRUITING · NA
-
Hyperpolarized 13C-pyruvate Metabolic MRI With Traumatic Brain Injury
RECRUITING · Phase 1
-
Carbon Dioxide Administration and Brain Waste Clearance
RECRUITING · NA
-
TMS-fNIRS Personalized Dosing
RECRUITING · NA
-
Cortical Spreading Depolarization After Severe Traumatic Brain Injury
RECRUITING
-
A Study to Evaluate the SENSE Device's Ability to Detect TBI
RECRUITING
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT04396613 · 147 participants · NA
Wound Closure Techniques in Primary Spine Surgery
- NCT04851119 · 147 participants · Phase 1
Tegavivint for the Treatment of Recurrent or Refractory Solid Tumors, Including Lymphomas and Desmoid Tumors
- NCT05523947 · 147 participants · Phase 1
Clinical Trial of YH32367 in Patients With HER2 Positive Locally Advanced or Metastatic Solid Tumor
- NCT06121843 · 147 participants · Phase 1
A Study to Evaluate the Safety, Effectiveness and Tolerable Dose of Arlocabtagene Autoleucel (BMS-986393) in Novel Combinations in Participants With Relapsed and/or Refractory Multiple Myeloma
Similar registry start date
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia
- NCT07125183 · started 2026-12 · Phase 2
Study on Efficacy and Tolerability of Weekly Doxorubicin in Elderly Patients With Advanced or Metastatic Leiomyosarcoma
- NCT07292298 · started 2026-11 · Phase 2
Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates
- NCT04263285 · started 2026-10 · NA
Treatment of Depression Post-SCI