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ClinicalTrials.gov 75 recruiting now official registry

Traumatic Brain Injury clinical trials

75 of 172 indexed Traumatic Brain Injury trials are currently recruiting.

172 US clinical trials · 75 currently recruiting

Traumatic Brain Injury is the subject of 172 registered US clinical trials on ClinicalTrials.gov, 75 of them currently open to new participants. 5 are in Phase 3-4 (later-stage) and 23 in Phase 1-2 (earlier-stage). The most active sponsor is VA Office of Research and Development, running 11 of these trials.

The research picture

Traumatic Brain Injury has 172 registered US clinical trials, 75 of them open to new participants right now, about 44% of the total.

75
recruiting participants now
44%
of trials open to enrollment
5
in Phase 3–4 (later-stage)
11
top sponsor: VA Office of Research and Development
Phase 111Phase 212Phase 33Phase 42

Active & Recent Trials

172 total, page 4 of 4

COMPLETED Phase 1 34 participants

Safety Study of RP-1127 (Glyburide for Injection) in Healthy Volunteers

Biogen

NCT01132703

COMPLETED NA 33 participants

rTMS to Improve Cognitive Function in TBI

VA Office of Research and Development

NCT02152540

COMPLETED NA 30 participants

Blended Reality Immersion for Geriatric Head Trauma: The BRIGHT Study

University of Maryland, Baltimore

NCT06074328

COMPLETED 26 participants

Eye Movement Recordings in the Diagnosis of Traumatic Brain Injury

VA Office of Research and Development

NCT00875589

COMPLETED 24 participants

Pilot Study of NeuroTriage Device in Patients with Potential Brain Injury And/or Impairment

University of Texas Southwestern Medical Center

NCT03761641

COMPLETED NA 24 participants

The Environment's Impact on Thinking When Added to Leg Cycling in People With TBI: VITAL

Kessler Foundation

NCT04901286

COMPLETED NA 23 participants

Optimizing Cognitive, Environmental, and Neuromotor Stimulation in Traumatic Brain Injury

Johns Hopkins University

NCT04073225

COMPLETED 20 participants

Optimizing Drug Doses in Critically Ill

University of North Carolina, Chapel Hill

NCT02437838

COMPLETED NA 19 participants

Clinical Trial to Improve the Magnetic Levator Prosthesis

Massachusetts Eye and Ear Infirmary

NCT03818204

COMPLETED 18 participants

Imaging Dopamine Function and Its Impact on Outcome After Traumatic Brain Injury (TBI)

Baylor Research Institute

NCT01850290

COMPLETED Phase 1 18 participants

Effects of TT301 on Cytokine Levels Post Endotoxin Challenge

OPKO Health

NCT01357421

COMPLETED NA 16 participants

Myoelectric Upper Limb Orthosis Use by Persons With TBI and Stroke

Northwestern University

NCT03215771

COMPLETED NA 15 participants

A Pilot Randomized Controlled Trial: CoINTEGRATE

University of Michigan

NCT05732285

COMPLETED 14 participants

Sleep Quality, Heart Rate Variability and Anxiety Following Brain Injury

Shirley Ryan AbilityLab

NCT04652895

COMPLETED Phase 1 14 participants

Vagus Nerve Stimulation to Treat Moderate Traumatic Brain Injury

CentraCare

NCT02974959

COMPLETED NA 13 participants

Telemedicine Brain Injury Coping Skills (BICS-T) Support Group for Brain Injury Survivors and Their Caregivers

Rehabilitation Hospital of Indiana

NCT04371211

COMPLETED 11 participants

Assessing Eye Tracking Features Following Sports-Related Concussion

Mayo Clinic

NCT02103803

COMPLETED NA 6 participants

Team Based Initiative Support

US Department of Veterans Affairs

NCT00771277

COMPLETED NA 5 participants

Restoration of Life Role Participation Through Cognitive and Motor Training for TBI

Malcom Randall VA Medical Center

NCT01158781

COMPLETED NA 5 participants

Treating Civilian Traumatic Brain Injury With High Definition Transcranial Direct Current Stimulation (ciTBI-HDtDCS)

The University of Texas at Dallas

NCT05408975

COMPLETED Phase 1 3 participants

Traumatic Brain Injury Peripheral Nerve Study

Abbott Medical Devices

NCT01588691

COMPLETED NA 1 participants

Using the Xbox Kinect for Chronic TBI

Washington D.C. Veterans Affairs Medical Center

NCT02889289

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Phase Distribution

PhaseTrial count
Phase 1 11
Phase 2 12
Phase 3 3
Phase 4 2

Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.

Reading the Traumatic Brain Injury Trial Landscape

172 indexed Traumatic Brain Injury studies · 75 recruiting (44%).

Phase mix: 5 late (III/IV) vs 23 early (I/II).

Top sponsor: VA Office of Research and Development (11 trials), 9 others listed. 22 shown below, recruiting first.

How to read this condition's trial landscape

That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.

Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.

All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.

Frequently Asked Questions

How many clinical trials are there for Traumatic Brain Injury?

PlainTrial tracks 172 US clinical trials for Traumatic Brain Injury, of which 75 are currently recruiting participants. Data sourced from ClinicalTrials.gov.

How do I find a recruiting trial for Traumatic Brain Injury?

Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.

Is this data current?

Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.

Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.

Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.

Verify with NIH →

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.