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Traumatic Brain Injury clinical trials
75 of 172 indexed Traumatic Brain Injury trials are currently recruiting.
172 US clinical trials · 75 currently recruiting
Traumatic Brain Injury is the subject of 172 registered US clinical trials on ClinicalTrials.gov, 75 of them currently open to new participants. 5 are in Phase 3-4 (later-stage) and 23 in Phase 1-2 (earlier-stage). The most active sponsor is VA Office of Research and Development, running 11 of these trials.
The research picture
Traumatic Brain Injury has 172 registered US clinical trials, 75 of them open to new participants right now, about 44% of the total.
- 75
- recruiting participants now
- 44%
- of trials open to enrollment
- 5
- in Phase 3–4 (later-stage)
- 11
- top sponsor: VA Office of Research and Development
Active & Recent Trials
172 total, page 4 of 4
Safety Study of RP-1127 (Glyburide for Injection) in Healthy Volunteers
Biogen
NCT01132703
rTMS to Improve Cognitive Function in TBI
VA Office of Research and Development
NCT02152540
Blended Reality Immersion for Geriatric Head Trauma: The BRIGHT Study
University of Maryland, Baltimore
NCT06074328
Eye Movement Recordings in the Diagnosis of Traumatic Brain Injury
VA Office of Research and Development
NCT00875589
Pilot Study of NeuroTriage Device in Patients with Potential Brain Injury And/or Impairment
University of Texas Southwestern Medical Center
NCT03761641
The Environment's Impact on Thinking When Added to Leg Cycling in People With TBI: VITAL
Kessler Foundation
NCT04901286
Optimizing Cognitive, Environmental, and Neuromotor Stimulation in Traumatic Brain Injury
Johns Hopkins University
NCT04073225
Optimizing Drug Doses in Critically Ill
University of North Carolina, Chapel Hill
NCT02437838
Clinical Trial to Improve the Magnetic Levator Prosthesis
Massachusetts Eye and Ear Infirmary
NCT03818204
Imaging Dopamine Function and Its Impact on Outcome After Traumatic Brain Injury (TBI)
Baylor Research Institute
NCT01850290
Effects of TT301 on Cytokine Levels Post Endotoxin Challenge
OPKO Health
NCT01357421
Myoelectric Upper Limb Orthosis Use by Persons With TBI and Stroke
Northwestern University
NCT03215771
A Pilot Randomized Controlled Trial: CoINTEGRATE
University of Michigan
NCT05732285
Sleep Quality, Heart Rate Variability and Anxiety Following Brain Injury
Shirley Ryan AbilityLab
NCT04652895
Vagus Nerve Stimulation to Treat Moderate Traumatic Brain Injury
CentraCare
NCT02974959
Telemedicine Brain Injury Coping Skills (BICS-T) Support Group for Brain Injury Survivors and Their Caregivers
Rehabilitation Hospital of Indiana
NCT04371211
Assessing Eye Tracking Features Following Sports-Related Concussion
Mayo Clinic
NCT02103803
Team Based Initiative Support
US Department of Veterans Affairs
NCT00771277
Restoration of Life Role Participation Through Cognitive and Motor Training for TBI
Malcom Randall VA Medical Center
NCT01158781
Treating Civilian Traumatic Brain Injury With High Definition Transcranial Direct Current Stimulation (ciTBI-HDtDCS)
The University of Texas at Dallas
NCT05408975
Traumatic Brain Injury Peripheral Nerve Study
Abbott Medical Devices
NCT01588691
Using the Xbox Kinect for Chronic TBI
Washington D.C. Veterans Affairs Medical Center
NCT02889289
Phase Distribution
| Phase | Trial count |
|---|---|
| Phase 1 | 11 |
| Phase 2 | 12 |
| Phase 3 | 3 |
| Phase 4 | 2 |
Top Sponsors
Source: ClinicalTrials.gov, National Library of Medicine. Data is informational only.
Reading the Traumatic Brain Injury Trial Landscape
172 indexed Traumatic Brain Injury studies · 75 recruiting (44%).
Phase mix: 5 late (III/IV) vs 23 early (I/II).
Top sponsor: VA Office of Research and Development (11 trials), 9 others listed. 22 shown below, recruiting first.
How to read this condition's trial landscape
That ratio is a useful proxy for activity level: a high share of recruiting studies often signals that research interest is current and that new enrollment opportunities are appearing, while a low share typically means the field is dominated by completed or follow-up work where most participant spots have already been filled. These counts reflect the public registry only and include studies at every stage of design, so they should be read as an index of research attention rather than as a measure of treatment availability.
Phase 1 and Phase 2 studies focus on early safety signals, dosing, and preliminary effect, while Phase 3 studies are typically the larger efficacy and safety trials submitted toward regulatory review, and Phase 4 studies follow approved interventions in real-world use. A condition weighted toward later phases often reflects a mature research pipeline with several interventions already close to or past approval, whereas a heavier early-phase tilt suggests the field is still exploring new mechanisms and candidate approaches.
All figures are derived from the public ClinicalTrials.gov dataset maintained by the National Library of Medicine and are reproduced here for reference. Inclusion of a trial, sponsor, or intervention on this page is neither an endorsement nor a recommendation, eligibility, protocol changes, and site-level status can shift frequently, so always verify current details on ClinicalTrials.gov and consult a qualified healthcare provider before acting on anything you see here.
Frequently Asked Questions
How many clinical trials are there for Traumatic Brain Injury?
PlainTrial tracks 172 US clinical trials for Traumatic Brain Injury, of which 75 are currently recruiting participants. Data sourced from ClinicalTrials.gov.
How do I find a recruiting trial for Traumatic Brain Injury?
Use the trial list above filtered by "Recruiting" status, or visit our trial finder at /recruiting to search by condition and state. Always discuss trial participation with your healthcare provider before enrolling.
Is this data current?
Data is sourced from ClinicalTrials.gov and reflects our most recent data pull. Trial status may have changed since then. Always verify current information at ClinicalTrials.gov before making decisions about participation.
Related
Disclaimer: This information is provided for informational purposes only and does not constitute professional advice. Data is sourced from ClinicalTrials.gov (National Library of Medicine). Consult a qualified professional before making decisions based on this data.
Read our methodology - how this data is sourced, computed, and verified.
Source: ClinicalTrials.gov (NIH/NLM) ClinicalTrials.gov AACT registry · 2026 Trial counts and statuses sourced from ClinicalTrials.gov. Sponsor counts include both industry and federal/academic sponsors.
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page aggregates every registered trial for this condition, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.